Metabolic Profiles of Obesity in American Indians: The Strong Heart Family Study
Obesity is a typical metabolic disorder resulting from the imbalance between energy intake and expenditure. American Indians suffer disproportionately high rates of obesity and diabetes. The goal of this study is to identify metabolic profiles of obesity in 431 normoglycemic American Indians partici...
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| creator | Zhao, Qi Zhu, Yun Best, Lyle G Umans, Jason G Uppal, Karan Tran, ViLinh T Jones, Dean P Lee, Elisa T Howard, Barbara V Zhao, Jinying |
| description | Obesity is a typical metabolic disorder resulting from the imbalance between energy intake and expenditure. American Indians suffer disproportionately high rates of obesity and diabetes. The goal of this study is to identify metabolic profiles of obesity in 431 normoglycemic American Indians participating in the Strong Heart Family Study. Using an untargeted liquid chromatography-mass spectrometry, we detected 1,364 distinct m/z features matched to known compounds in the current metabolomics databases. We conducted multivariate analysis to identify metabolic profiles for obesity, adjusting for standard obesity indicators. After adjusting for covariates and multiple testing, five metabolites were associated with body mass index and seven were associated with waist circumference. Of them, three were associated with both. Majority of the obesity-related metabolites belongs to lipids, e.g., fatty amides, sphingolipids, prenol lipids, and steroid derivatives. Other identified metabolites are amino acids or peptides. Of the nine identified metabolites, five metabolites (oleoylethanolamide, mannosyl-diinositol-phosphorylceramide, pristanic acid, glutamate, and kynurenine) have been previously implicated in obesity or its related pathways. Future studies are warranted to replicate these findings in larger populations or other ethnic groups. |
| doi_str_mv | 10.1371/journal.pone.0159548 |
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American Indians suffer disproportionately high rates of obesity and diabetes. The goal of this study is to identify metabolic profiles of obesity in 431 normoglycemic American Indians participating in the Strong Heart Family Study. Using an untargeted liquid chromatography-mass spectrometry, we detected 1,364 distinct m/z features matched to known compounds in the current metabolomics databases. We conducted multivariate analysis to identify metabolic profiles for obesity, adjusting for standard obesity indicators. After adjusting for covariates and multiple testing, five metabolites were associated with body mass index and seven were associated with waist circumference. Of them, three were associated with both. Majority of the obesity-related metabolites belongs to lipids, e.g., fatty amides, sphingolipids, prenol lipids, and steroid derivatives. Other identified metabolites are amino acids or peptides. Of the nine identified metabolites, five metabolites (oleoylethanolamide, mannosyl-diinositol-phosphorylceramide, pristanic acid, glutamate, and kynurenine) have been previously implicated in obesity or its related pathways. Future studies are warranted to replicate these findings in larger populations or other ethnic groups.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0159548</identifier><identifier>PMID: 27434237</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; American Indians ; Amides ; Amino acids ; Amino Acids - blood ; Analysis ; Biology and Life Sciences ; Blood Glucose - metabolism ; Body mass ; Body Mass Index ; Body size ; Chromatography ; Chromatography, Liquid ; Databases, Factual ; Diabetes mellitus ; Energy intake ; Family studies ; Fasting ; Female ; Health aspects ; Humans ; Indians, North American ; Insulin Resistance ; Lipid metabolism ; Lipids ; Liquid chromatography ; Male ; Mass Spectrometry ; Mass spectroscopy ; Medicine and Health Sciences ; Metabolic disorders ; Metabolites ; Metabolome ; Metabolomics ; Metabolomics - methods ; Middle Aged ; Minority & ethnic groups ; Multivariate analysis ; Native Americans ; Native North Americans ; Nutrition ; Obesity ; Obesity - blood ; Obesity - diagnosis ; Obesity - ethnology ; Obesity - physiopathology ; Oleic acid ; Peptides ; Peptides - blood ; Physiological aspects ; Prospective Studies ; Risk Factors ; Sphingolipids ; Sphingolipids - blood ; Steroids - blood ; United States ; Waist Circumference</subject><ispartof>PloS one, 2016-07, Vol.11 (7), p.e0159548-e0159548</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Zhao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Zhao et al 2016 Zhao et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-99a4c42d9f5e342d30166fff7159de7ac1cefc9166c25ffebb15d5470d060b0d3</citedby><cites>FETCH-LOGICAL-c725t-99a4c42d9f5e342d30166fff7159de7ac1cefc9166c25ffebb15d5470d060b0d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951134/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951134/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2106,2932,23875,27933,27934,53800,53802</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27434237$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Cota, Daniela</contributor><creatorcontrib>Zhao, Qi</creatorcontrib><creatorcontrib>Zhu, Yun</creatorcontrib><creatorcontrib>Best, Lyle G</creatorcontrib><creatorcontrib>Umans, Jason G</creatorcontrib><creatorcontrib>Uppal, Karan</creatorcontrib><creatorcontrib>Tran, ViLinh T</creatorcontrib><creatorcontrib>Jones, Dean P</creatorcontrib><creatorcontrib>Lee, Elisa T</creatorcontrib><creatorcontrib>Howard, Barbara V</creatorcontrib><creatorcontrib>Zhao, Jinying</creatorcontrib><title>Metabolic Profiles of Obesity in American Indians: The Strong Heart Family Study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Obesity is a typical metabolic disorder resulting from the imbalance between energy intake and expenditure. American Indians suffer disproportionately high rates of obesity and diabetes. The goal of this study is to identify metabolic profiles of obesity in 431 normoglycemic American Indians participating in the Strong Heart Family Study. Using an untargeted liquid chromatography-mass spectrometry, we detected 1,364 distinct m/z features matched to known compounds in the current metabolomics databases. We conducted multivariate analysis to identify metabolic profiles for obesity, adjusting for standard obesity indicators. After adjusting for covariates and multiple testing, five metabolites were associated with body mass index and seven were associated with waist circumference. Of them, three were associated with both. Majority of the obesity-related metabolites belongs to lipids, e.g., fatty amides, sphingolipids, prenol lipids, and steroid derivatives. Other identified metabolites are amino acids or peptides. Of the nine identified metabolites, five metabolites (oleoylethanolamide, mannosyl-diinositol-phosphorylceramide, pristanic acid, glutamate, and kynurenine) have been previously implicated in obesity or its related pathways. Future studies are warranted to replicate these findings in larger populations or other ethnic groups.</description><subject>Adolescent</subject><subject>Adult</subject><subject>American Indians</subject><subject>Amides</subject><subject>Amino acids</subject><subject>Amino Acids - blood</subject><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Body size</subject><subject>Chromatography</subject><subject>Chromatography, Liquid</subject><subject>Databases, Factual</subject><subject>Diabetes mellitus</subject><subject>Energy intake</subject><subject>Family studies</subject><subject>Fasting</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Indians, North American</subject><subject>Insulin Resistance</subject><subject>Lipid metabolism</subject><subject>Lipids</subject><subject>Liquid chromatography</subject><subject>Male</subject><subject>Mass Spectrometry</subject><subject>Mass spectroscopy</subject><subject>Medicine and Health Sciences</subject><subject>Metabolic disorders</subject><subject>Metabolites</subject><subject>Metabolome</subject><subject>Metabolomics</subject><subject>Metabolomics - 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American Indians suffer disproportionately high rates of obesity and diabetes. The goal of this study is to identify metabolic profiles of obesity in 431 normoglycemic American Indians participating in the Strong Heart Family Study. Using an untargeted liquid chromatography-mass spectrometry, we detected 1,364 distinct m/z features matched to known compounds in the current metabolomics databases. We conducted multivariate analysis to identify metabolic profiles for obesity, adjusting for standard obesity indicators. After adjusting for covariates and multiple testing, five metabolites were associated with body mass index and seven were associated with waist circumference. Of them, three were associated with both. Majority of the obesity-related metabolites belongs to lipids, e.g., fatty amides, sphingolipids, prenol lipids, and steroid derivatives. Other identified metabolites are amino acids or peptides. Of the nine identified metabolites, five metabolites (oleoylethanolamide, mannosyl-diinositol-phosphorylceramide, pristanic acid, glutamate, and kynurenine) have been previously implicated in obesity or its related pathways. Future studies are warranted to replicate these findings in larger populations or other ethnic groups.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27434237</pmid><doi>10.1371/journal.pone.0159548</doi><tpages>e0159548</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-07, Vol.11 (7), p.e0159548-e0159548 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1805485249 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult American Indians Amides Amino acids Amino Acids - blood Analysis Biology and Life Sciences Blood Glucose - metabolism Body mass Body Mass Index Body size Chromatography Chromatography, Liquid Databases, Factual Diabetes mellitus Energy intake Family studies Fasting Female Health aspects Humans Indians, North American Insulin Resistance Lipid metabolism Lipids Liquid chromatography Male Mass Spectrometry Mass spectroscopy Medicine and Health Sciences Metabolic disorders Metabolites Metabolome Metabolomics Metabolomics - methods Middle Aged Minority & ethnic groups Multivariate analysis Native Americans Native North Americans Nutrition Obesity Obesity - blood Obesity - diagnosis Obesity - ethnology Obesity - physiopathology Oleic acid Peptides Peptides - blood Physiological aspects Prospective Studies Risk Factors Sphingolipids Sphingolipids - blood Steroids - blood United States Waist Circumference |
| title | Metabolic Profiles of Obesity in American Indians: The Strong Heart Family Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-03T09%3A47%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Metabolic%20Profiles%20of%20Obesity%20in%20American%20Indians:%20The%20Strong%20Heart%20Family%20Study&rft.jtitle=PloS%20one&rft.au=Zhao,%20Qi&rft.date=2016-07-19&rft.volume=11&rft.issue=7&rft.spage=e0159548&rft.epage=e0159548&rft.pages=e0159548-e0159548&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0159548&rft_dat=%3Cgale_plos_%3EA458747603%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1805485249&rft_id=info:pmid/27434237&rft_galeid=A458747603&rft_doaj_id=oai_doaj_org_article_70bd1647f1eb4933b3a8ed74c1f1a205&rfr_iscdi=true |