Efficient In Vitro and In Vivo Activity of Glyco-Engineered Plant-Produced Rabies Monoclonal Antibodies E559 and 62-71-3

Rabies is a neglected zoonotic disease that has no effective treatment after onset of illness. However the disease can be prevented effectively by prompt administration of post exposure prophylaxis which includes administration of passive immunizing antibodies (Rabies Immune Globulin, RIG). Currentl...

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Veröffentlicht in:	PloS one 2016-07, Vol.11 (7), p.e0159313
Hauptverfasser:	Tsekoa, Tsepo Lebiletsa, Lotter-Stark, Therese, Buthelezi, Sindisiwe, Chakauya, Ereck, Stoychev, Stoyan H, Sabeta, Claude, Shumba, Wonderful, Phahladira, Baby, Hume, Steve, Morton, Josh, Rupprecht, Charles E, Steinkellner, Herta, Pauly, Michael, Zeitlin, Larry, Whaley, Kevin, Chikwamba, Rachel
Format:	Artikel
Sprache:	eng
Schlagworte:	Agrobacterium tumefaciens - genetics Agrobacterium tumefaciens - metabolism Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - biosynthesis Antibodies, Monoclonal - genetics Antibodies, Viral - administration & dosage Antibodies, Viral - biosynthesis Antibodies, Viral - genetics Biology and life sciences Cancer Cloning, Molecular Contamination Councils Dosage and administration Exposure Female Fucose Gene Expression Genetic Vectors - chemistry Genetic Vectors - metabolism Globulins Glycosylation Immunization Immunization, Passive Immunoglobulins Lyssavirus Mass spectrometry Mass spectroscopy Medical treatment Medicine and Health Sciences Mesocricetus Methods Monoclonal antibodies Mutants N-glycans Neutralization Tests Nicotiana - genetics Nicotiana - metabolism Nicotiana benthamiana People and places Plants, Genetically Modified Polysaccharides Prophylaxis Rabies Rabies - immunology Rabies - mortality Rabies - prevention & control Rabies - virology Rabies vaccines Rabies Vaccines - administration & dosage Rabies Vaccines - biosynthesis Rabies virus Rabies virus - drug effects Rabies virus - growth & development Rabies virus - immunology Rabies virus - pathogenicity Recombinant Proteins - administration & dosage Recombinant Proteins - biosynthesis Recombinant Proteins - genetics Survival Analysis Vectors (Biology) Viruses Zoonoses
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