Neuromuscular Strain Increases Symptom Intensity in Chronic Fatigue Syndrome
Chronic fatigue syndrome (CFS) is a complex, multisystem disorder that can be disabling. CFS symptoms can be provoked by increased physical or cognitive activity, and by orthostatic stress. In preliminary work, we noted that CFS symptoms also could be provoked by application of longitudinal neural a...
Gespeichert in:
| Veröffentlicht in: | PloS one 2016-07, Vol.11 (7), p.e0159386-e0159386 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0159386 |
|---|---|
| container_issue | 7 |
| container_start_page | e0159386 |
| container_title | PloS one |
| container_volume | 11 |
| creator | Rowe, Peter C Fontaine, Kevin R Lauver, Megan Jasion, Samantha E Marden, Colleen L Moni, Malini Thompson, Carol B Violand, Richard L |
| description | Chronic fatigue syndrome (CFS) is a complex, multisystem disorder that can be disabling. CFS symptoms can be provoked by increased physical or cognitive activity, and by orthostatic stress. In preliminary work, we noted that CFS symptoms also could be provoked by application of longitudinal neural and soft tissue strain to the limbs and spine of affected individuals. In this study we measured the responses to a straight leg raise neuromuscular strain maneuver in individuals with CFS and healthy controls. We randomly assigned 60 individuals with CFS and 20 healthy controls to either a 15 minute period of passive supine straight leg raise (true neuromuscular strain) or a sham straight leg raise. The primary outcome measure was the symptom intensity difference between the scores during and 24 hours after the study maneuver compared to baseline. Fatigue, body pain, lightheadedness, concentration difficulties, and headache scores were measured individually on a 0-10 scale, and summed to create a composite symptom score. Compared to individuals with CFS in the sham strain group, those with CFS in the true strain group reported significantly increased body pain (P = 0.04) and concentration difficulties (P = 0.02) as well as increased composite symptom scores (all P = 0.03) during the maneuver. After 24 hours, the symptom intensity differences were significantly greater for the CFS true strain group for the individual symptom of lightheadedness (P = 0.001) and for the composite symptom score (P = 0.005). During and 24 hours after the exposure to the true strain maneuver, those with CFS had significantly higher individual and composite symptom intensity changes compared to the healthy controls. We conclude that a longitudinal strain applied to the nerves and soft tissues of the lower limb is capable of increasing symptom intensity in individuals with CFS for up to 24 hours. These findings support our preliminary observations that increased mechanical sensitivity may be a contributor to the provocation of symptoms in this disorder. |
| doi_str_mv | 10.1371/journal.pone.0159386 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1805472170</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A458639427</galeid><doaj_id>oai_doaj_org_article_813ee94573194788ad532bdece8c00b5</doaj_id><sourcerecordid>A458639427</sourcerecordid><originalsourceid>FETCH-LOGICAL-c725t-2312d5149a031a3a23ad332b8dcae50ac042655d139921954d930b04108ba8893</originalsourceid><addsrcrecordid>eNqNk9-LEzEQxxdRvPP0PxAtCKIPrfm5SV6Eo3haKB5Y9TWkSdqm7Ca9JCv2vze97h1duYcjDwkzn_lmMpOpqtcQTCBm8NM2dNGrZrIL3k4ApALz-kl1DgVG4xoB_PTkfFa9SGkLAC1M_bw6Q4wgjik_r-bfbRdD2yXdNSqOFjkq50czr6NVyabRYt_ucmiLJVufXN6Pinu6icE7PbpS2a07WyBvioh9WT1bqSbZV_1-Uf26-vJz-m08v_46m17Ox5ohmscIQ2QoJEIBDBVWCCuDMVpyo5WlQGlAUE2pgVgIBAUlRmCwBAQCvlScC3xRvT3q7pqQZF-IJCEHlDAEGSjE7EiYoLZyF12r4l4G5eStIcS1VDE73VjJIbZWEMowFIRxrgwtuRirLdcALGnR-tzf1i1ba7T1pUjNQHTo8W4j1-GPJIJwzg8CH3qBGG46m7JsXdK2aZS3obvNmzPMQA0eg1JWM0xwQd_9hz5ciJ5aq_JW51ehpKgPovKSUF5jQRAr1OQBqixjW6fLB1u5Yh8EfBwEFCbbv3mtupTkbPHj8ez17yH7_oTdWNXkTQpNl13waQiSI6hjSCna1X0_IJCH-birhjzMh-zno4S9Oe3lfdDdQOB_tH0IgA</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1805472170</pqid></control><display><type>article</type><title>Neuromuscular Strain Increases Symptom Intensity in Chronic Fatigue Syndrome</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Rowe, Peter C ; Fontaine, Kevin R ; Lauver, Megan ; Jasion, Samantha E ; Marden, Colleen L ; Moni, Malini ; Thompson, Carol B ; Violand, Richard L</creator><creatorcontrib>Rowe, Peter C ; Fontaine, Kevin R ; Lauver, Megan ; Jasion, Samantha E ; Marden, Colleen L ; Moni, Malini ; Thompson, Carol B ; Violand, Richard L</creatorcontrib><description>Chronic fatigue syndrome (CFS) is a complex, multisystem disorder that can be disabling. CFS symptoms can be provoked by increased physical or cognitive activity, and by orthostatic stress. In preliminary work, we noted that CFS symptoms also could be provoked by application of longitudinal neural and soft tissue strain to the limbs and spine of affected individuals. In this study we measured the responses to a straight leg raise neuromuscular strain maneuver in individuals with CFS and healthy controls. We randomly assigned 60 individuals with CFS and 20 healthy controls to either a 15 minute period of passive supine straight leg raise (true neuromuscular strain) or a sham straight leg raise. The primary outcome measure was the symptom intensity difference between the scores during and 24 hours after the study maneuver compared to baseline. Fatigue, body pain, lightheadedness, concentration difficulties, and headache scores were measured individually on a 0-10 scale, and summed to create a composite symptom score. Compared to individuals with CFS in the sham strain group, those with CFS in the true strain group reported significantly increased body pain (P = 0.04) and concentration difficulties (P = 0.02) as well as increased composite symptom scores (all P = 0.03) during the maneuver. After 24 hours, the symptom intensity differences were significantly greater for the CFS true strain group for the individual symptom of lightheadedness (P = 0.001) and for the composite symptom score (P = 0.005). During and 24 hours after the exposure to the true strain maneuver, those with CFS had significantly higher individual and composite symptom intensity changes compared to the healthy controls. We conclude that a longitudinal strain applied to the nerves and soft tissues of the lower limb is capable of increasing symptom intensity in individuals with CFS for up to 24 hours. These findings support our preliminary observations that increased mechanical sensitivity may be a contributor to the provocation of symptoms in this disorder.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0159386</identifier><identifier>PMID: 27428358</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Analysis ; Biology and Life Sciences ; Biomechanical Phenomena ; Cardiac arrhythmia ; Case-Control Studies ; Chronic fatigue syndrome ; Cognitive ability ; Dizziness - physiopathology ; Drug dosages ; Fatigue ; Fatigue Syndrome, Chronic - complications ; Fatigue Syndrome, Chronic - diagnosis ; Fatigue Syndrome, Chronic - physiopathology ; Female ; Fibromyalgia ; Headache ; Headache - physiopathology ; Health care ; Heart rate ; Humans ; Leg ; Leg - innervation ; Leg - physiopathology ; Male ; Manipulative therapy ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Muscular fatigue ; Nerves ; Nervous system ; Occupational health ; Pain ; Pediatrics ; Public health ; Quality of life ; Risk factors ; Severity of Illness Index ; Soft tissues ; Spine ; Sprains and Strains - complications ; Sprains and Strains - diagnosis ; Sprains and Strains - physiopathology ; Stress, Mechanical ; Tissues ; True strain ; Young adults</subject><ispartof>PloS one, 2016-07, Vol.11 (7), p.e0159386-e0159386</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Rowe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Rowe et al 2016 Rowe et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-2312d5149a031a3a23ad332b8dcae50ac042655d139921954d930b04108ba8893</citedby><cites>FETCH-LOGICAL-c725t-2312d5149a031a3a23ad332b8dcae50ac042655d139921954d930b04108ba8893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948885/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948885/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27428358$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rowe, Peter C</creatorcontrib><creatorcontrib>Fontaine, Kevin R</creatorcontrib><creatorcontrib>Lauver, Megan</creatorcontrib><creatorcontrib>Jasion, Samantha E</creatorcontrib><creatorcontrib>Marden, Colleen L</creatorcontrib><creatorcontrib>Moni, Malini</creatorcontrib><creatorcontrib>Thompson, Carol B</creatorcontrib><creatorcontrib>Violand, Richard L</creatorcontrib><title>Neuromuscular Strain Increases Symptom Intensity in Chronic Fatigue Syndrome</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Chronic fatigue syndrome (CFS) is a complex, multisystem disorder that can be disabling. CFS symptoms can be provoked by increased physical or cognitive activity, and by orthostatic stress. In preliminary work, we noted that CFS symptoms also could be provoked by application of longitudinal neural and soft tissue strain to the limbs and spine of affected individuals. In this study we measured the responses to a straight leg raise neuromuscular strain maneuver in individuals with CFS and healthy controls. We randomly assigned 60 individuals with CFS and 20 healthy controls to either a 15 minute period of passive supine straight leg raise (true neuromuscular strain) or a sham straight leg raise. The primary outcome measure was the symptom intensity difference between the scores during and 24 hours after the study maneuver compared to baseline. Fatigue, body pain, lightheadedness, concentration difficulties, and headache scores were measured individually on a 0-10 scale, and summed to create a composite symptom score. Compared to individuals with CFS in the sham strain group, those with CFS in the true strain group reported significantly increased body pain (P = 0.04) and concentration difficulties (P = 0.02) as well as increased composite symptom scores (all P = 0.03) during the maneuver. After 24 hours, the symptom intensity differences were significantly greater for the CFS true strain group for the individual symptom of lightheadedness (P = 0.001) and for the composite symptom score (P = 0.005). During and 24 hours after the exposure to the true strain maneuver, those with CFS had significantly higher individual and composite symptom intensity changes compared to the healthy controls. We conclude that a longitudinal strain applied to the nerves and soft tissues of the lower limb is capable of increasing symptom intensity in individuals with CFS for up to 24 hours. These findings support our preliminary observations that increased mechanical sensitivity may be a contributor to the provocation of symptoms in this disorder.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Biomechanical Phenomena</subject><subject>Cardiac arrhythmia</subject><subject>Case-Control Studies</subject><subject>Chronic fatigue syndrome</subject><subject>Cognitive ability</subject><subject>Dizziness - physiopathology</subject><subject>Drug dosages</subject><subject>Fatigue</subject><subject>Fatigue Syndrome, Chronic - complications</subject><subject>Fatigue Syndrome, Chronic - diagnosis</subject><subject>Fatigue Syndrome, Chronic - physiopathology</subject><subject>Female</subject><subject>Fibromyalgia</subject><subject>Headache</subject><subject>Headache - physiopathology</subject><subject>Health care</subject><subject>Heart rate</subject><subject>Humans</subject><subject>Leg</subject><subject>Leg - innervation</subject><subject>Leg - physiopathology</subject><subject>Male</subject><subject>Manipulative therapy</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Muscular fatigue</subject><subject>Nerves</subject><subject>Nervous system</subject><subject>Occupational health</subject><subject>Pain</subject><subject>Pediatrics</subject><subject>Public health</subject><subject>Quality of life</subject><subject>Risk factors</subject><subject>Severity of Illness Index</subject><subject>Soft tissues</subject><subject>Spine</subject><subject>Sprains and Strains - complications</subject><subject>Sprains and Strains - diagnosis</subject><subject>Sprains and Strains - physiopathology</subject><subject>Stress, Mechanical</subject><subject>Tissues</subject><subject>True strain</subject><subject>Young adults</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9-LEzEQxxdRvPP0PxAtCKIPrfm5SV6Eo3haKB5Y9TWkSdqm7Ca9JCv2vze97h1duYcjDwkzn_lmMpOpqtcQTCBm8NM2dNGrZrIL3k4ApALz-kl1DgVG4xoB_PTkfFa9SGkLAC1M_bw6Q4wgjik_r-bfbRdD2yXdNSqOFjkq50czr6NVyabRYt_ucmiLJVufXN6Pinu6icE7PbpS2a07WyBvioh9WT1bqSbZV_1-Uf26-vJz-m08v_46m17Ox5ohmscIQ2QoJEIBDBVWCCuDMVpyo5WlQGlAUE2pgVgIBAUlRmCwBAQCvlScC3xRvT3q7pqQZF-IJCEHlDAEGSjE7EiYoLZyF12r4l4G5eStIcS1VDE73VjJIbZWEMowFIRxrgwtuRirLdcALGnR-tzf1i1ba7T1pUjNQHTo8W4j1-GPJIJwzg8CH3qBGG46m7JsXdK2aZS3obvNmzPMQA0eg1JWM0xwQd_9hz5ciJ5aq_JW51ehpKgPovKSUF5jQRAr1OQBqixjW6fLB1u5Yh8EfBwEFCbbv3mtupTkbPHj8ez17yH7_oTdWNXkTQpNl13waQiSI6hjSCna1X0_IJCH-birhjzMh-zno4S9Oe3lfdDdQOB_tH0IgA</recordid><startdate>20160718</startdate><enddate>20160718</enddate><creator>Rowe, Peter C</creator><creator>Fontaine, Kevin R</creator><creator>Lauver, Megan</creator><creator>Jasion, Samantha E</creator><creator>Marden, Colleen L</creator><creator>Moni, Malini</creator><creator>Thompson, Carol B</creator><creator>Violand, Richard L</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20160718</creationdate><title>Neuromuscular Strain Increases Symptom Intensity in Chronic Fatigue Syndrome</title><author>Rowe, Peter C ; Fontaine, Kevin R ; Lauver, Megan ; Jasion, Samantha E ; Marden, Colleen L ; Moni, Malini ; Thompson, Carol B ; Violand, Richard L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c725t-2312d5149a031a3a23ad332b8dcae50ac042655d139921954d930b04108ba8893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Analysis</topic><topic>Biology and Life Sciences</topic><topic>Biomechanical Phenomena</topic><topic>Cardiac arrhythmia</topic><topic>Case-Control Studies</topic><topic>Chronic fatigue syndrome</topic><topic>Cognitive ability</topic><topic>Dizziness - physiopathology</topic><topic>Drug dosages</topic><topic>Fatigue</topic><topic>Fatigue Syndrome, Chronic - complications</topic><topic>Fatigue Syndrome, Chronic - diagnosis</topic><topic>Fatigue Syndrome, Chronic - physiopathology</topic><topic>Female</topic><topic>Fibromyalgia</topic><topic>Headache</topic><topic>Headache - physiopathology</topic><topic>Health care</topic><topic>Heart rate</topic><topic>Humans</topic><topic>Leg</topic><topic>Leg - innervation</topic><topic>Leg - physiopathology</topic><topic>Male</topic><topic>Manipulative therapy</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Muscular fatigue</topic><topic>Nerves</topic><topic>Nervous system</topic><topic>Occupational health</topic><topic>Pain</topic><topic>Pediatrics</topic><topic>Public health</topic><topic>Quality of life</topic><topic>Risk factors</topic><topic>Severity of Illness Index</topic><topic>Soft tissues</topic><topic>Spine</topic><topic>Sprains and Strains - complications</topic><topic>Sprains and Strains - diagnosis</topic><topic>Sprains and Strains - physiopathology</topic><topic>Stress, Mechanical</topic><topic>Tissues</topic><topic>True strain</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rowe, Peter C</creatorcontrib><creatorcontrib>Fontaine, Kevin R</creatorcontrib><creatorcontrib>Lauver, Megan</creatorcontrib><creatorcontrib>Jasion, Samantha E</creatorcontrib><creatorcontrib>Marden, Colleen L</creatorcontrib><creatorcontrib>Moni, Malini</creatorcontrib><creatorcontrib>Thompson, Carol B</creatorcontrib><creatorcontrib>Violand, Richard L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rowe, Peter C</au><au>Fontaine, Kevin R</au><au>Lauver, Megan</au><au>Jasion, Samantha E</au><au>Marden, Colleen L</au><au>Moni, Malini</au><au>Thompson, Carol B</au><au>Violand, Richard L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuromuscular Strain Increases Symptom Intensity in Chronic Fatigue Syndrome</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-07-18</date><risdate>2016</risdate><volume>11</volume><issue>7</issue><spage>e0159386</spage><epage>e0159386</epage><pages>e0159386-e0159386</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Chronic fatigue syndrome (CFS) is a complex, multisystem disorder that can be disabling. CFS symptoms can be provoked by increased physical or cognitive activity, and by orthostatic stress. In preliminary work, we noted that CFS symptoms also could be provoked by application of longitudinal neural and soft tissue strain to the limbs and spine of affected individuals. In this study we measured the responses to a straight leg raise neuromuscular strain maneuver in individuals with CFS and healthy controls. We randomly assigned 60 individuals with CFS and 20 healthy controls to either a 15 minute period of passive supine straight leg raise (true neuromuscular strain) or a sham straight leg raise. The primary outcome measure was the symptom intensity difference between the scores during and 24 hours after the study maneuver compared to baseline. Fatigue, body pain, lightheadedness, concentration difficulties, and headache scores were measured individually on a 0-10 scale, and summed to create a composite symptom score. Compared to individuals with CFS in the sham strain group, those with CFS in the true strain group reported significantly increased body pain (P = 0.04) and concentration difficulties (P = 0.02) as well as increased composite symptom scores (all P = 0.03) during the maneuver. After 24 hours, the symptom intensity differences were significantly greater for the CFS true strain group for the individual symptom of lightheadedness (P = 0.001) and for the composite symptom score (P = 0.005). During and 24 hours after the exposure to the true strain maneuver, those with CFS had significantly higher individual and composite symptom intensity changes compared to the healthy controls. We conclude that a longitudinal strain applied to the nerves and soft tissues of the lower limb is capable of increasing symptom intensity in individuals with CFS for up to 24 hours. These findings support our preliminary observations that increased mechanical sensitivity may be a contributor to the provocation of symptoms in this disorder.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27428358</pmid><doi>10.1371/journal.pone.0159386</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-07, Vol.11 (7), p.e0159386-e0159386 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1805472170 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adolescent Adult Analysis Biology and Life Sciences Biomechanical Phenomena Cardiac arrhythmia Case-Control Studies Chronic fatigue syndrome Cognitive ability Dizziness - physiopathology Drug dosages Fatigue Fatigue Syndrome, Chronic - complications Fatigue Syndrome, Chronic - diagnosis Fatigue Syndrome, Chronic - physiopathology Female Fibromyalgia Headache Headache - physiopathology Health care Heart rate Humans Leg Leg - innervation Leg - physiopathology Male Manipulative therapy Medicine Medicine and Health Sciences Middle Aged Muscular fatigue Nerves Nervous system Occupational health Pain Pediatrics Public health Quality of life Risk factors Severity of Illness Index Soft tissues Spine Sprains and Strains - complications Sprains and Strains - diagnosis Sprains and Strains - physiopathology Stress, Mechanical Tissues True strain Young adults |
| title | Neuromuscular Strain Increases Symptom Intensity in Chronic Fatigue Syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T04%3A17%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neuromuscular%20Strain%20Increases%20Symptom%20Intensity%20in%20Chronic%20Fatigue%20Syndrome&rft.jtitle=PloS%20one&rft.au=Rowe,%20Peter%20C&rft.date=2016-07-18&rft.volume=11&rft.issue=7&rft.spage=e0159386&rft.epage=e0159386&rft.pages=e0159386-e0159386&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0159386&rft_dat=%3Cgale_plos_%3EA458639427%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1805472170&rft_id=info:pmid/27428358&rft_galeid=A458639427&rft_doaj_id=oai_doaj_org_article_813ee94573194788ad532bdece8c00b5&rfr_iscdi=true |