Age, Spatial, and Temporal Variations in Hospital Admissions with Malaria in Kilifi County, Kenya: A 25-Year Longitudinal Observational Study
Encouraging progress has been seen with reductions in Plasmodium falciparum malaria transmission in some parts of Africa. Reduced transmission might lead to increasing susceptibility to malaria among older children due to lower acquired immunity, and this has implications for ongoing control strateg...
Gespeichert in:
| Veröffentlicht in: | PLoS medicine 2016-06, Vol.13 (6), p.e1002047-e1002047 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e1002047 |
|---|---|
| container_issue | 6 |
| container_start_page | e1002047 |
| container_title | PLoS medicine |
| container_volume | 13 |
| creator | Mogeni, Polycarp Williams, Thomas N Fegan, Gregory Nyundo, Christopher Bauni, Evasius Mwai, Kennedy Omedo, Irene Njuguna, Patricia Newton, Charles R Osier, Faith Berkley, James A Hammitt, Laura L Lowe, Brett Mwambingu, Gabriel Awuondo, Ken Mturi, Neema Peshu, Norbert Snow, Robert W Noor, Abdisalan Marsh, Kevin Bejon, Philip |
| description | Encouraging progress has been seen with reductions in Plasmodium falciparum malaria transmission in some parts of Africa. Reduced transmission might lead to increasing susceptibility to malaria among older children due to lower acquired immunity, and this has implications for ongoing control strategies.
We conducted a longitudinal observational study of children admitted to Kilifi County Hospital in Kenya and linked it to data on residence and insecticide-treated net (ITN) use. This included data from 69,104 children aged from 3 mo to 13 y admitted to Kilifi County Hospital between 1 January 1990 and 31 December 2014. The variation in malaria slide positivity among admissions was examined in logistic regression models using the following predictors: location of the residence, calendar time, the child's age, ITN use, and the enhanced vegetation index (a proxy for soil moisture). The proportion of malaria slide-positive admissions declined from 0.56 (95% confidence interval [CI] 0.54-0.58) in 1998 to 0.07 (95% CI 0.06-0.08) in 2009 but then increased again through to 0.24 (95% CI 0.22-0.25) in 2014. Older children accounted for most of the increase after 2009 (0.035 [95% CI 0.030-0.040] among young children compared to 0.22 [95% CI 0.21-0.23] in older children). There was a nonlinear relationship between malaria risk and prevalence of ITN use within a 2 km radius of an admitted child's residence such that the predicted malaria positive fraction varied from ~0.4 to |
| doi_str_mv | 10.1371/journal.pmed.1002047 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1805469859</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A479522955</galeid><doaj_id>oai_doaj_org_article_617a8ff97cc04c669de8300dd5341971</doaj_id><sourcerecordid>A479522955</sourcerecordid><originalsourceid>FETCH-LOGICAL-c764t-b5ca24e4158bd4bed920e023c0464f1cafef75d139fe9af80c5b8e6e4c7b05303</originalsourceid><addsrcrecordid>eNqVk1Fv0zAQxyMEYmPwDRBYmoRAaoqd2EnMA1JVAatWqETHJJ4sx7mkrlK7xMmgH4LvjNt1U4P6AMpDkn9-9787Xy4InhM8JHFK3i5t1xhZD9crKIYE4wjT9EFwShjlIUnS5OHB80nwxLmlZzjm-HFwEqUxi2Icnwa_RxUM0HwtWy3rAZKmQFewWttG1uhaNtrr1jikDbqwbq1bL4-KlXZuJ__U7QJ9lvUW3DKXutalRmPbmXYzQJdgNvIdGqGIhd9BNmhqTaXbrtC-cDTLHTQ3uwT-be7lzdPgUSlrB8_297Pg28cPV-OLcDr7NBmPpqFKE9qGOVMyokAJy_KC5lDwCAOOYoVpQkuiZAllygoS8xK4LDOsWJ5BAlSlOWa-77Pg5a3vurZO7E_SCZJhRhOeMe6JyS1RWLkU60avZLMRVmqxE2xTCdm0WtUgEpLKrCx5qnx-lSS8gCzGuChYTAlPifd6v8_W5X5YCkzrj7dn2v9i9EJU9kZQHtGUZ97g9d6gsT86cK3wE1BQ19KA7XZ14xRHCaYePf8LPd7dnqqkb0Cb0vq8amsqRj4jiyLOmKfCI1QFBnyR1kCpvdzjh0d4fxWw0upowJtegGda-NVWsnNOTOZf_4P98u_s7LrPvjpgFyDrduFs3e3--z5Ib0HVWOcaKO8HSLDYbuTdSYvtRor9RvqwF4fDvw-6W8H4DwBOL4Y</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1805469859</pqid></control><display><type>article</type><title>Age, Spatial, and Temporal Variations in Hospital Admissions with Malaria in Kilifi County, Kenya: A 25-Year Longitudinal Observational Study</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Public Library of Science (PLoS)</source><creator>Mogeni, Polycarp ; Williams, Thomas N ; Fegan, Gregory ; Nyundo, Christopher ; Bauni, Evasius ; Mwai, Kennedy ; Omedo, Irene ; Njuguna, Patricia ; Newton, Charles R ; Osier, Faith ; Berkley, James A ; Hammitt, Laura L ; Lowe, Brett ; Mwambingu, Gabriel ; Awuondo, Ken ; Mturi, Neema ; Peshu, Norbert ; Snow, Robert W ; Noor, Abdisalan ; Marsh, Kevin ; Bejon, Philip</creator><contributor>Grais, Rebecca Freeman</contributor><creatorcontrib>Mogeni, Polycarp ; Williams, Thomas N ; Fegan, Gregory ; Nyundo, Christopher ; Bauni, Evasius ; Mwai, Kennedy ; Omedo, Irene ; Njuguna, Patricia ; Newton, Charles R ; Osier, Faith ; Berkley, James A ; Hammitt, Laura L ; Lowe, Brett ; Mwambingu, Gabriel ; Awuondo, Ken ; Mturi, Neema ; Peshu, Norbert ; Snow, Robert W ; Noor, Abdisalan ; Marsh, Kevin ; Bejon, Philip ; Grais, Rebecca Freeman</creatorcontrib><description>Encouraging progress has been seen with reductions in Plasmodium falciparum malaria transmission in some parts of Africa. Reduced transmission might lead to increasing susceptibility to malaria among older children due to lower acquired immunity, and this has implications for ongoing control strategies.
We conducted a longitudinal observational study of children admitted to Kilifi County Hospital in Kenya and linked it to data on residence and insecticide-treated net (ITN) use. This included data from 69,104 children aged from 3 mo to 13 y admitted to Kilifi County Hospital between 1 January 1990 and 31 December 2014. The variation in malaria slide positivity among admissions was examined in logistic regression models using the following predictors: location of the residence, calendar time, the child's age, ITN use, and the enhanced vegetation index (a proxy for soil moisture). The proportion of malaria slide-positive admissions declined from 0.56 (95% confidence interval [CI] 0.54-0.58) in 1998 to 0.07 (95% CI 0.06-0.08) in 2009 but then increased again through to 0.24 (95% CI 0.22-0.25) in 2014. Older children accounted for most of the increase after 2009 (0.035 [95% CI 0.030-0.040] among young children compared to 0.22 [95% CI 0.21-0.23] in older children). There was a nonlinear relationship between malaria risk and prevalence of ITN use within a 2 km radius of an admitted child's residence such that the predicted malaria positive fraction varied from ~0.4 to <0.1 as the prevalence of ITN use varied from 20% to 80%. In this observational analysis, we were unable to determine the cause of the decline in malaria between 1998 and 2009, which pre-dated the dramatic scale-up in ITN distribution and use.
Following a period of reduced transmission, a cohort of older children emerged who have increased susceptibility to malaria. Further reductions in malaria transmission are needed to mitigate the increasing burden among older children, and universal ITN coverage is a promising strategy to achieve this goal.</description><identifier>ISSN: 1549-1676</identifier><identifier>ISSN: 1549-1277</identifier><identifier>EISSN: 1549-1676</identifier><identifier>DOI: 10.1371/journal.pmed.1002047</identifier><identifier>PMID: 27352303</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Age ; Biology and Life Sciences ; Child ; Child, Preschool ; Children & youth ; Confidence intervals ; Female ; Funding ; Hospital admission and discharge ; Hospitalization - statistics & numerical data ; Hospitalization - trends ; Humans ; Infant ; Insecticide-Treated Bednets - statistics & numerical data ; Insecticides ; Kenya - epidemiology ; Logistics ; Longitudinal Studies ; Malaria ; Malaria - epidemiology ; Malaria - parasitology ; Male ; Management ; Medicine and Health Sciences ; Mosquito Control - statistics & numerical data ; Parasites ; People and Places ; Plasmodium falciparum ; Prevalence ; Researchers ; Risk ; Risk factors ; Studies ; Surveillance ; Trends</subject><ispartof>PLoS medicine, 2016-06, Vol.13 (6), p.e1002047-e1002047</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Mogeni P, Williams TN, Fegan G, Nyundo C, Bauni E, Mwai K, et al. (2016) Age, Spatial, and Temporal Variations in Hospital Admissions with Malaria in Kilifi County, Kenya: A 25-Year Longitudinal Observational Study. PLoS Med 13(6): e1002047. doi:10.1371/journal.pmed.1002047</rights><rights>2016 Mogeni et al 2016 Mogeni et al</rights><rights>2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Mogeni P, Williams TN, Fegan G, Nyundo C, Bauni E, Mwai K, et al. (2016) Age, Spatial, and Temporal Variations in Hospital Admissions with Malaria in Kilifi County, Kenya: A 25-Year Longitudinal Observational Study. PLoS Med 13(6): e1002047. doi:10.1371/journal.pmed.1002047</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c764t-b5ca24e4158bd4bed920e023c0464f1cafef75d139fe9af80c5b8e6e4c7b05303</citedby><cites>FETCH-LOGICAL-c764t-b5ca24e4158bd4bed920e023c0464f1cafef75d139fe9af80c5b8e6e4c7b05303</cites><orcidid>0000-0002-8038-3894 ; 0000-0002-4422-8627 ; 0000-0002-2663-2765 ; 0000-0002-7757-7516 ; 0000-0002-9276-8759</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924798/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924798/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27352303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Grais, Rebecca Freeman</contributor><creatorcontrib>Mogeni, Polycarp</creatorcontrib><creatorcontrib>Williams, Thomas N</creatorcontrib><creatorcontrib>Fegan, Gregory</creatorcontrib><creatorcontrib>Nyundo, Christopher</creatorcontrib><creatorcontrib>Bauni, Evasius</creatorcontrib><creatorcontrib>Mwai, Kennedy</creatorcontrib><creatorcontrib>Omedo, Irene</creatorcontrib><creatorcontrib>Njuguna, Patricia</creatorcontrib><creatorcontrib>Newton, Charles R</creatorcontrib><creatorcontrib>Osier, Faith</creatorcontrib><creatorcontrib>Berkley, James A</creatorcontrib><creatorcontrib>Hammitt, Laura L</creatorcontrib><creatorcontrib>Lowe, Brett</creatorcontrib><creatorcontrib>Mwambingu, Gabriel</creatorcontrib><creatorcontrib>Awuondo, Ken</creatorcontrib><creatorcontrib>Mturi, Neema</creatorcontrib><creatorcontrib>Peshu, Norbert</creatorcontrib><creatorcontrib>Snow, Robert W</creatorcontrib><creatorcontrib>Noor, Abdisalan</creatorcontrib><creatorcontrib>Marsh, Kevin</creatorcontrib><creatorcontrib>Bejon, Philip</creatorcontrib><title>Age, Spatial, and Temporal Variations in Hospital Admissions with Malaria in Kilifi County, Kenya: A 25-Year Longitudinal Observational Study</title><title>PLoS medicine</title><addtitle>PLoS Med</addtitle><description>Encouraging progress has been seen with reductions in Plasmodium falciparum malaria transmission in some parts of Africa. Reduced transmission might lead to increasing susceptibility to malaria among older children due to lower acquired immunity, and this has implications for ongoing control strategies.
We conducted a longitudinal observational study of children admitted to Kilifi County Hospital in Kenya and linked it to data on residence and insecticide-treated net (ITN) use. This included data from 69,104 children aged from 3 mo to 13 y admitted to Kilifi County Hospital between 1 January 1990 and 31 December 2014. The variation in malaria slide positivity among admissions was examined in logistic regression models using the following predictors: location of the residence, calendar time, the child's age, ITN use, and the enhanced vegetation index (a proxy for soil moisture). The proportion of malaria slide-positive admissions declined from 0.56 (95% confidence interval [CI] 0.54-0.58) in 1998 to 0.07 (95% CI 0.06-0.08) in 2009 but then increased again through to 0.24 (95% CI 0.22-0.25) in 2014. Older children accounted for most of the increase after 2009 (0.035 [95% CI 0.030-0.040] among young children compared to 0.22 [95% CI 0.21-0.23] in older children). There was a nonlinear relationship between malaria risk and prevalence of ITN use within a 2 km radius of an admitted child's residence such that the predicted malaria positive fraction varied from ~0.4 to <0.1 as the prevalence of ITN use varied from 20% to 80%. In this observational analysis, we were unable to determine the cause of the decline in malaria between 1998 and 2009, which pre-dated the dramatic scale-up in ITN distribution and use.
Following a period of reduced transmission, a cohort of older children emerged who have increased susceptibility to malaria. Further reductions in malaria transmission are needed to mitigate the increasing burden among older children, and universal ITN coverage is a promising strategy to achieve this goal.</description><subject>Adolescent</subject><subject>Age</subject><subject>Biology and Life Sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children & youth</subject><subject>Confidence intervals</subject><subject>Female</subject><subject>Funding</subject><subject>Hospital admission and discharge</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Hospitalization - trends</subject><subject>Humans</subject><subject>Infant</subject><subject>Insecticide-Treated Bednets - statistics & numerical data</subject><subject>Insecticides</subject><subject>Kenya - epidemiology</subject><subject>Logistics</subject><subject>Longitudinal Studies</subject><subject>Malaria</subject><subject>Malaria - epidemiology</subject><subject>Malaria - parasitology</subject><subject>Male</subject><subject>Management</subject><subject>Medicine and Health Sciences</subject><subject>Mosquito Control - statistics & numerical data</subject><subject>Parasites</subject><subject>People and Places</subject><subject>Plasmodium falciparum</subject><subject>Prevalence</subject><subject>Researchers</subject><subject>Risk</subject><subject>Risk factors</subject><subject>Studies</subject><subject>Surveillance</subject><subject>Trends</subject><issn>1549-1676</issn><issn>1549-1277</issn><issn>1549-1676</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqVk1Fv0zAQxyMEYmPwDRBYmoRAaoqd2EnMA1JVAatWqETHJJ4sx7mkrlK7xMmgH4LvjNt1U4P6AMpDkn9-9787Xy4InhM8JHFK3i5t1xhZD9crKIYE4wjT9EFwShjlIUnS5OHB80nwxLmlZzjm-HFwEqUxi2Icnwa_RxUM0HwtWy3rAZKmQFewWttG1uhaNtrr1jikDbqwbq1bL4-KlXZuJ__U7QJ9lvUW3DKXutalRmPbmXYzQJdgNvIdGqGIhd9BNmhqTaXbrtC-cDTLHTQ3uwT-be7lzdPgUSlrB8_297Pg28cPV-OLcDr7NBmPpqFKE9qGOVMyokAJy_KC5lDwCAOOYoVpQkuiZAllygoS8xK4LDOsWJ5BAlSlOWa-77Pg5a3vurZO7E_SCZJhRhOeMe6JyS1RWLkU60avZLMRVmqxE2xTCdm0WtUgEpLKrCx5qnx-lSS8gCzGuChYTAlPifd6v8_W5X5YCkzrj7dn2v9i9EJU9kZQHtGUZ97g9d6gsT86cK3wE1BQ19KA7XZ14xRHCaYePf8LPd7dnqqkb0Cb0vq8amsqRj4jiyLOmKfCI1QFBnyR1kCpvdzjh0d4fxWw0upowJtegGda-NVWsnNOTOZf_4P98u_s7LrPvjpgFyDrduFs3e3--z5Ib0HVWOcaKO8HSLDYbuTdSYvtRor9RvqwF4fDvw-6W8H4DwBOL4Y</recordid><startdate>20160628</startdate><enddate>20160628</enddate><creator>Mogeni, Polycarp</creator><creator>Williams, Thomas N</creator><creator>Fegan, Gregory</creator><creator>Nyundo, Christopher</creator><creator>Bauni, Evasius</creator><creator>Mwai, Kennedy</creator><creator>Omedo, Irene</creator><creator>Njuguna, Patricia</creator><creator>Newton, Charles R</creator><creator>Osier, Faith</creator><creator>Berkley, James A</creator><creator>Hammitt, Laura L</creator><creator>Lowe, Brett</creator><creator>Mwambingu, Gabriel</creator><creator>Awuondo, Ken</creator><creator>Mturi, Neema</creator><creator>Peshu, Norbert</creator><creator>Snow, Robert W</creator><creator>Noor, Abdisalan</creator><creator>Marsh, Kevin</creator><creator>Bejon, Philip</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISN</scope><scope>ISR</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><scope>CZK</scope><orcidid>https://orcid.org/0000-0002-8038-3894</orcidid><orcidid>https://orcid.org/0000-0002-4422-8627</orcidid><orcidid>https://orcid.org/0000-0002-2663-2765</orcidid><orcidid>https://orcid.org/0000-0002-7757-7516</orcidid><orcidid>https://orcid.org/0000-0002-9276-8759</orcidid></search><sort><creationdate>20160628</creationdate><title>Age, Spatial, and Temporal Variations in Hospital Admissions with Malaria in Kilifi County, Kenya: A 25-Year Longitudinal Observational Study</title><author>Mogeni, Polycarp ; Williams, Thomas N ; Fegan, Gregory ; Nyundo, Christopher ; Bauni, Evasius ; Mwai, Kennedy ; Omedo, Irene ; Njuguna, Patricia ; Newton, Charles R ; Osier, Faith ; Berkley, James A ; Hammitt, Laura L ; Lowe, Brett ; Mwambingu, Gabriel ; Awuondo, Ken ; Mturi, Neema ; Peshu, Norbert ; Snow, Robert W ; Noor, Abdisalan ; Marsh, Kevin ; Bejon, Philip</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c764t-b5ca24e4158bd4bed920e023c0464f1cafef75d139fe9af80c5b8e6e4c7b05303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Age</topic><topic>Biology and Life Sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children & youth</topic><topic>Confidence intervals</topic><topic>Female</topic><topic>Funding</topic><topic>Hospital admission and discharge</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Hospitalization - trends</topic><topic>Humans</topic><topic>Infant</topic><topic>Insecticide-Treated Bednets - statistics & numerical data</topic><topic>Insecticides</topic><topic>Kenya - epidemiology</topic><topic>Logistics</topic><topic>Longitudinal Studies</topic><topic>Malaria</topic><topic>Malaria - epidemiology</topic><topic>Malaria - parasitology</topic><topic>Male</topic><topic>Management</topic><topic>Medicine and Health Sciences</topic><topic>Mosquito Control - statistics & numerical data</topic><topic>Parasites</topic><topic>People and Places</topic><topic>Plasmodium falciparum</topic><topic>Prevalence</topic><topic>Researchers</topic><topic>Risk</topic><topic>Risk factors</topic><topic>Studies</topic><topic>Surveillance</topic><topic>Trends</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mogeni, Polycarp</creatorcontrib><creatorcontrib>Williams, Thomas N</creatorcontrib><creatorcontrib>Fegan, Gregory</creatorcontrib><creatorcontrib>Nyundo, Christopher</creatorcontrib><creatorcontrib>Bauni, Evasius</creatorcontrib><creatorcontrib>Mwai, Kennedy</creatorcontrib><creatorcontrib>Omedo, Irene</creatorcontrib><creatorcontrib>Njuguna, Patricia</creatorcontrib><creatorcontrib>Newton, Charles R</creatorcontrib><creatorcontrib>Osier, Faith</creatorcontrib><creatorcontrib>Berkley, James A</creatorcontrib><creatorcontrib>Hammitt, Laura L</creatorcontrib><creatorcontrib>Lowe, Brett</creatorcontrib><creatorcontrib>Mwambingu, Gabriel</creatorcontrib><creatorcontrib>Awuondo, Ken</creatorcontrib><creatorcontrib>Mturi, Neema</creatorcontrib><creatorcontrib>Peshu, Norbert</creatorcontrib><creatorcontrib>Snow, Robert W</creatorcontrib><creatorcontrib>Noor, Abdisalan</creatorcontrib><creatorcontrib>Marsh, Kevin</creatorcontrib><creatorcontrib>Bejon, Philip</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><collection>PLoS Medicine</collection><jtitle>PLoS medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mogeni, Polycarp</au><au>Williams, Thomas N</au><au>Fegan, Gregory</au><au>Nyundo, Christopher</au><au>Bauni, Evasius</au><au>Mwai, Kennedy</au><au>Omedo, Irene</au><au>Njuguna, Patricia</au><au>Newton, Charles R</au><au>Osier, Faith</au><au>Berkley, James A</au><au>Hammitt, Laura L</au><au>Lowe, Brett</au><au>Mwambingu, Gabriel</au><au>Awuondo, Ken</au><au>Mturi, Neema</au><au>Peshu, Norbert</au><au>Snow, Robert W</au><au>Noor, Abdisalan</au><au>Marsh, Kevin</au><au>Bejon, Philip</au><au>Grais, Rebecca Freeman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age, Spatial, and Temporal Variations in Hospital Admissions with Malaria in Kilifi County, Kenya: A 25-Year Longitudinal Observational Study</atitle><jtitle>PLoS medicine</jtitle><addtitle>PLoS Med</addtitle><date>2016-06-28</date><risdate>2016</risdate><volume>13</volume><issue>6</issue><spage>e1002047</spage><epage>e1002047</epage><pages>e1002047-e1002047</pages><issn>1549-1676</issn><issn>1549-1277</issn><eissn>1549-1676</eissn><abstract>Encouraging progress has been seen with reductions in Plasmodium falciparum malaria transmission in some parts of Africa. Reduced transmission might lead to increasing susceptibility to malaria among older children due to lower acquired immunity, and this has implications for ongoing control strategies.
We conducted a longitudinal observational study of children admitted to Kilifi County Hospital in Kenya and linked it to data on residence and insecticide-treated net (ITN) use. This included data from 69,104 children aged from 3 mo to 13 y admitted to Kilifi County Hospital between 1 January 1990 and 31 December 2014. The variation in malaria slide positivity among admissions was examined in logistic regression models using the following predictors: location of the residence, calendar time, the child's age, ITN use, and the enhanced vegetation index (a proxy for soil moisture). The proportion of malaria slide-positive admissions declined from 0.56 (95% confidence interval [CI] 0.54-0.58) in 1998 to 0.07 (95% CI 0.06-0.08) in 2009 but then increased again through to 0.24 (95% CI 0.22-0.25) in 2014. Older children accounted for most of the increase after 2009 (0.035 [95% CI 0.030-0.040] among young children compared to 0.22 [95% CI 0.21-0.23] in older children). There was a nonlinear relationship between malaria risk and prevalence of ITN use within a 2 km radius of an admitted child's residence such that the predicted malaria positive fraction varied from ~0.4 to <0.1 as the prevalence of ITN use varied from 20% to 80%. In this observational analysis, we were unable to determine the cause of the decline in malaria between 1998 and 2009, which pre-dated the dramatic scale-up in ITN distribution and use.
Following a period of reduced transmission, a cohort of older children emerged who have increased susceptibility to malaria. Further reductions in malaria transmission are needed to mitigate the increasing burden among older children, and universal ITN coverage is a promising strategy to achieve this goal.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27352303</pmid><doi>10.1371/journal.pmed.1002047</doi><orcidid>https://orcid.org/0000-0002-8038-3894</orcidid><orcidid>https://orcid.org/0000-0002-4422-8627</orcidid><orcidid>https://orcid.org/0000-0002-2663-2765</orcidid><orcidid>https://orcid.org/0000-0002-7757-7516</orcidid><orcidid>https://orcid.org/0000-0002-9276-8759</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1549-1676 |
| ispartof | PLoS medicine, 2016-06, Vol.13 (6), p.e1002047-e1002047 |
| issn | 1549-1676 1549-1277 1549-1676 |
| language | eng |
| recordid | cdi_plos_journals_1805469859 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Public Library of Science (PLoS) |
| subjects | Adolescent Age Biology and Life Sciences Child Child, Preschool Children & youth Confidence intervals Female Funding Hospital admission and discharge Hospitalization - statistics & numerical data Hospitalization - trends Humans Infant Insecticide-Treated Bednets - statistics & numerical data Insecticides Kenya - epidemiology Logistics Longitudinal Studies Malaria Malaria - epidemiology Malaria - parasitology Male Management Medicine and Health Sciences Mosquito Control - statistics & numerical data Parasites People and Places Plasmodium falciparum Prevalence Researchers Risk Risk factors Studies Surveillance Trends |
| title | Age, Spatial, and Temporal Variations in Hospital Admissions with Malaria in Kilifi County, Kenya: A 25-Year Longitudinal Observational Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T20%3A58%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Age,%20Spatial,%20and%20Temporal%20Variations%20in%20Hospital%20Admissions%20with%20Malaria%20in%20Kilifi%20County,%20Kenya:%20A%2025-Year%20Longitudinal%20Observational%20Study&rft.jtitle=PLoS%20medicine&rft.au=Mogeni,%20Polycarp&rft.date=2016-06-28&rft.volume=13&rft.issue=6&rft.spage=e1002047&rft.epage=e1002047&rft.pages=e1002047-e1002047&rft.issn=1549-1676&rft.eissn=1549-1676&rft_id=info:doi/10.1371/journal.pmed.1002047&rft_dat=%3Cgale_plos_%3EA479522955%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1805469859&rft_id=info:pmid/27352303&rft_galeid=A479522955&rft_doaj_id=oai_doaj_org_article_617a8ff97cc04c669de8300dd5341971&rfr_iscdi=true |