Prevalence of Sexually Transmitted Viral and Bacterial Infections in HIV-Positive and HIV-Negative Men Who Have Sex with Men in Toronto
Hepatitis B (HBV), hepatitis C (HCV) and other sexually transmitted infections (STIs) have been associated with HIV transmission risk and disease progression among gay men and other men who have sex with men (MSM), but the frequency and distribution of STIs in this community in Canada has not been e...
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| Veröffentlicht in: | PloS one 2016-07, Vol.11 (7), p.e0158090-e0158090 |
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| creator | Remis, Robert S Liu, Juan Loutfy, Mona R Tharao, Wangari Rebbapragada, Anuradha Huibner, Sanja Kesler, Maya Halpenny, Roberta Grennan, Troy Brunetta, Jason Smith, Graham Reko, Tatjana Kaul, Rupert |
| description | Hepatitis B (HBV), hepatitis C (HCV) and other sexually transmitted infections (STIs) have been associated with HIV transmission risk and disease progression among gay men and other men who have sex with men (MSM), but the frequency and distribution of STIs in this community in Canada has not been extensively studied.
We recruited MSM living with and without HIV from a large primary care clinic in Toronto. Participants completed a detailed socio-behavioural questionnaire using ACASI and provided blood for syphilis, HIV, HBV and HCV, herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), and human cytomegalovirus (CMV) serology, urine for chlamydia and gonorrhea, and a self-collected anal swab for human papillomavirus (HPV) molecular diagnostics. Prevalences were expressed as a proportion and compared using chi-square.
442 MSM were recruited, 294 living with HIV and 148 without. Active syphilis (11.0% vs. 3.4%), ever HBV (49.4% vs. 19.1%), HCV (10.4% vs. 3.4%), HSV-2 (55.9% vs. 38.2%), CMV (98.3% vs. 80.3%) and high-risk (HR) anal HPV (67.6% vs. 51.7%) infections were significantly more common in men living with HIV. Chlamydia and gonorrhea were infrequent in both groups. Regardless of HIV infection status, age and number of lifetime male sexual partners were associated with HBV infection and lifetime injection drug use with HCV infection.
Syphilis and viral infections, including HBV, HCV, HSV-2, CMV, and HR-HPV, were common in this clinic-based population of MSM in Toronto and more frequent among MSM living with HIV. This argues for the implementation of routine screening, vaccine-based prevention, and education programs in this high-risk population. |
| doi_str_mv | 10.1371/journal.pone.0158090 |
| format | Article |
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We recruited MSM living with and without HIV from a large primary care clinic in Toronto. Participants completed a detailed socio-behavioural questionnaire using ACASI and provided blood for syphilis, HIV, HBV and HCV, herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), and human cytomegalovirus (CMV) serology, urine for chlamydia and gonorrhea, and a self-collected anal swab for human papillomavirus (HPV) molecular diagnostics. Prevalences were expressed as a proportion and compared using chi-square.
442 MSM were recruited, 294 living with HIV and 148 without. Active syphilis (11.0% vs. 3.4%), ever HBV (49.4% vs. 19.1%), HCV (10.4% vs. 3.4%), HSV-2 (55.9% vs. 38.2%), CMV (98.3% vs. 80.3%) and high-risk (HR) anal HPV (67.6% vs. 51.7%) infections were significantly more common in men living with HIV. Chlamydia and gonorrhea were infrequent in both groups. Regardless of HIV infection status, age and number of lifetime male sexual partners were associated with HBV infection and lifetime injection drug use with HCV infection.
Syphilis and viral infections, including HBV, HCV, HSV-2, CMV, and HR-HPV, were common in this clinic-based population of MSM in Toronto and more frequent among MSM living with HIV. This argues for the implementation of routine screening, vaccine-based prevention, and education programs in this high-risk population.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0158090</identifier><identifier>PMID: 27391265</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acasis ; Acquired immune deficiency syndrome ; Adult ; AIDS ; Bacteria ; Bacterial infections ; Bacterial Infections - complications ; Bacterial Infections - epidemiology ; Biology and Life Sciences ; Chlamydia ; Chlamydia Infections - complications ; Chlamydia Infections - epidemiology ; Chlamydia trachomatis ; Coinfection - epidemiology ; Cytomegalovirus ; Cytomegalovirus Infections - complications ; Cytomegalovirus Infections - epidemiology ; Demographic aspects ; Disease Progression ; Disease transmission ; Diseases ; Drug abuse ; Gay men ; Gonorrhea ; Gonorrhea - complications ; Gonorrhea - epidemiology ; Health care networks ; Health risk assessment ; Health risks ; Hepatitis ; Hepatitis B ; Hepatitis B - complications ; Hepatitis B - epidemiology ; Hepatitis B virus ; Hepatitis C ; Hepatitis C - complications ; Hepatitis C - epidemiology ; Hepatitis C virus ; Herpes simplex ; Herpes Simplex - complications ; Herpes Simplex - epidemiology ; Herpes simplex virus 1 ; Herpes simplex virus 2 ; Herpes viruses ; Herpesviridae ; HIV ; HIV Infections - complications ; HIV Infections - epidemiology ; HIV positive ; Homosexuality, Male ; Human cytomegalovirus ; Human immunodeficiency virus ; Human papillomavirus ; Humans ; Infections ; Laboratories ; Lentivirus ; Male ; Medicine ; Medicine and Health Sciences ; Men ; Middle Aged ; Native North Americans ; Neisseria gonorrhoeae ; Ontario - epidemiology ; Papillomaviridae ; Papillomavirus Infections - complications ; Papillomavirus Infections - epidemiology ; People and Places ; Prevalence ; Public health ; Retroviridae ; Risk factors ; Serology ; Sex ; Sexual Behavior ; Sexual Partners ; Sexually transmitted diseases ; Sexually Transmitted Diseases - complications ; Sexually Transmitted Diseases - epidemiology ; STD ; Surveys and Questionnaires ; Syphilis ; Syphilis - complications ; Syphilis - epidemiology ; Treponema pallidum ; Urine ; Virus Diseases - complications ; Virus Diseases - epidemiology ; Viruses ; Womens health</subject><ispartof>PloS one, 2016-07, Vol.11 (7), p.e0158090-e0158090</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Remis et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Remis et al 2016 Remis et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c655t-87a21b6b8ab244411e164dce6ca8892d44b1bc25dc36af17c25beff2215770db3</citedby><cites>FETCH-LOGICAL-c655t-87a21b6b8ab244411e164dce6ca8892d44b1bc25dc36af17c25beff2215770db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938580/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938580/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27391265$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Baral, Stefan</contributor><creatorcontrib>Remis, Robert S</creatorcontrib><creatorcontrib>Liu, Juan</creatorcontrib><creatorcontrib>Loutfy, Mona R</creatorcontrib><creatorcontrib>Tharao, Wangari</creatorcontrib><creatorcontrib>Rebbapragada, Anuradha</creatorcontrib><creatorcontrib>Huibner, Sanja</creatorcontrib><creatorcontrib>Kesler, Maya</creatorcontrib><creatorcontrib>Halpenny, Roberta</creatorcontrib><creatorcontrib>Grennan, Troy</creatorcontrib><creatorcontrib>Brunetta, Jason</creatorcontrib><creatorcontrib>Smith, Graham</creatorcontrib><creatorcontrib>Reko, Tatjana</creatorcontrib><creatorcontrib>Kaul, Rupert</creatorcontrib><title>Prevalence of Sexually Transmitted Viral and Bacterial Infections in HIV-Positive and HIV-Negative Men Who Have Sex with Men in Toronto</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Hepatitis B (HBV), hepatitis C (HCV) and other sexually transmitted infections (STIs) have been associated with HIV transmission risk and disease progression among gay men and other men who have sex with men (MSM), but the frequency and distribution of STIs in this community in Canada has not been extensively studied.
We recruited MSM living with and without HIV from a large primary care clinic in Toronto. Participants completed a detailed socio-behavioural questionnaire using ACASI and provided blood for syphilis, HIV, HBV and HCV, herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), and human cytomegalovirus (CMV) serology, urine for chlamydia and gonorrhea, and a self-collected anal swab for human papillomavirus (HPV) molecular diagnostics. Prevalences were expressed as a proportion and compared using chi-square.
442 MSM were recruited, 294 living with HIV and 148 without. Active syphilis (11.0% vs. 3.4%), ever HBV (49.4% vs. 19.1%), HCV (10.4% vs. 3.4%), HSV-2 (55.9% vs. 38.2%), CMV (98.3% vs. 80.3%) and high-risk (HR) anal HPV (67.6% vs. 51.7%) infections were significantly more common in men living with HIV. Chlamydia and gonorrhea were infrequent in both groups. Regardless of HIV infection status, age and number of lifetime male sexual partners were associated with HBV infection and lifetime injection drug use with HCV infection.
Syphilis and viral infections, including HBV, HCV, HSV-2, CMV, and HR-HPV, were common in this clinic-based population of MSM in Toronto and more frequent among MSM living with HIV. This argues for the implementation of routine screening, vaccine-based prevention, and education programs in this high-risk population.</description><subject>Acasis</subject><subject>Acquired immune deficiency syndrome</subject><subject>Adult</subject><subject>AIDS</subject><subject>Bacteria</subject><subject>Bacterial infections</subject><subject>Bacterial Infections - complications</subject><subject>Bacterial Infections - epidemiology</subject><subject>Biology and Life Sciences</subject><subject>Chlamydia</subject><subject>Chlamydia Infections - complications</subject><subject>Chlamydia Infections - epidemiology</subject><subject>Chlamydia trachomatis</subject><subject>Coinfection - epidemiology</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus Infections - complications</subject><subject>Cytomegalovirus Infections - epidemiology</subject><subject>Demographic aspects</subject><subject>Disease Progression</subject><subject>Disease transmission</subject><subject>Diseases</subject><subject>Drug abuse</subject><subject>Gay men</subject><subject>Gonorrhea</subject><subject>Gonorrhea - complications</subject><subject>Gonorrhea - epidemiology</subject><subject>Health care networks</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis B - complications</subject><subject>Hepatitis B - epidemiology</subject><subject>Hepatitis B virus</subject><subject>Hepatitis C</subject><subject>Hepatitis C - complications</subject><subject>Hepatitis C - epidemiology</subject><subject>Hepatitis C virus</subject><subject>Herpes simplex</subject><subject>Herpes Simplex - complications</subject><subject>Herpes Simplex - epidemiology</subject><subject>Herpes simplex virus 1</subject><subject>Herpes simplex virus 2</subject><subject>Herpes viruses</subject><subject>Herpesviridae</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - epidemiology</subject><subject>HIV positive</subject><subject>Homosexuality, Male</subject><subject>Human cytomegalovirus</subject><subject>Human immunodeficiency virus</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Lentivirus</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Men</subject><subject>Middle Aged</subject><subject>Native North Americans</subject><subject>Neisseria gonorrhoeae</subject><subject>Ontario - epidemiology</subject><subject>Papillomaviridae</subject><subject>Papillomavirus Infections - complications</subject><subject>Papillomavirus Infections - epidemiology</subject><subject>People and Places</subject><subject>Prevalence</subject><subject>Public health</subject><subject>Retroviridae</subject><subject>Risk factors</subject><subject>Serology</subject><subject>Sex</subject><subject>Sexual Behavior</subject><subject>Sexual Partners</subject><subject>Sexually transmitted diseases</subject><subject>Sexually Transmitted Diseases - complications</subject><subject>Sexually Transmitted Diseases - epidemiology</subject><subject>STD</subject><subject>Surveys and Questionnaires</subject><subject>Syphilis</subject><subject>Syphilis - complications</subject><subject>Syphilis - epidemiology</subject><subject>Treponema pallidum</subject><subject>Urine</subject><subject>Virus Diseases - complications</subject><subject>Virus Diseases - epidemiology</subject><subject>Viruses</subject><subject>Womens 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C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Remis, Robert S</au><au>Liu, Juan</au><au>Loutfy, Mona R</au><au>Tharao, Wangari</au><au>Rebbapragada, Anuradha</au><au>Huibner, Sanja</au><au>Kesler, Maya</au><au>Halpenny, Roberta</au><au>Grennan, Troy</au><au>Brunetta, Jason</au><au>Smith, Graham</au><au>Reko, Tatjana</au><au>Kaul, Rupert</au><au>Baral, Stefan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of Sexually Transmitted Viral and Bacterial Infections in HIV-Positive and HIV-Negative Men Who Have Sex with Men in Toronto</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-07-08</date><risdate>2016</risdate><volume>11</volume><issue>7</issue><spage>e0158090</spage><epage>e0158090</epage><pages>e0158090-e0158090</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Hepatitis B (HBV), hepatitis C (HCV) and other sexually transmitted infections (STIs) have been associated with HIV transmission risk and disease progression among gay men and other men who have sex with men (MSM), but the frequency and distribution of STIs in this community in Canada has not been extensively studied.
We recruited MSM living with and without HIV from a large primary care clinic in Toronto. Participants completed a detailed socio-behavioural questionnaire using ACASI and provided blood for syphilis, HIV, HBV and HCV, herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), and human cytomegalovirus (CMV) serology, urine for chlamydia and gonorrhea, and a self-collected anal swab for human papillomavirus (HPV) molecular diagnostics. Prevalences were expressed as a proportion and compared using chi-square.
442 MSM were recruited, 294 living with HIV and 148 without. Active syphilis (11.0% vs. 3.4%), ever HBV (49.4% vs. 19.1%), HCV (10.4% vs. 3.4%), HSV-2 (55.9% vs. 38.2%), CMV (98.3% vs. 80.3%) and high-risk (HR) anal HPV (67.6% vs. 51.7%) infections were significantly more common in men living with HIV. Chlamydia and gonorrhea were infrequent in both groups. Regardless of HIV infection status, age and number of lifetime male sexual partners were associated with HBV infection and lifetime injection drug use with HCV infection.
Syphilis and viral infections, including HBV, HCV, HSV-2, CMV, and HR-HPV, were common in this clinic-based population of MSM in Toronto and more frequent among MSM living with HIV. This argues for the implementation of routine screening, vaccine-based prevention, and education programs in this high-risk population.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27391265</pmid><doi>10.1371/journal.pone.0158090</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-07, Vol.11 (7), p.e0158090-e0158090 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1802588880 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acasis Acquired immune deficiency syndrome Adult AIDS Bacteria Bacterial infections Bacterial Infections - complications Bacterial Infections - epidemiology Biology and Life Sciences Chlamydia Chlamydia Infections - complications Chlamydia Infections - epidemiology Chlamydia trachomatis Coinfection - epidemiology Cytomegalovirus Cytomegalovirus Infections - complications Cytomegalovirus Infections - epidemiology Demographic aspects Disease Progression Disease transmission Diseases Drug abuse Gay men Gonorrhea Gonorrhea - complications Gonorrhea - epidemiology Health care networks Health risk assessment Health risks Hepatitis Hepatitis B Hepatitis B - complications Hepatitis B - epidemiology Hepatitis B virus Hepatitis C Hepatitis C - complications Hepatitis C - epidemiology Hepatitis C virus Herpes simplex Herpes Simplex - complications Herpes Simplex - epidemiology Herpes simplex virus 1 Herpes simplex virus 2 Herpes viruses Herpesviridae HIV HIV Infections - complications HIV Infections - epidemiology HIV positive Homosexuality, Male Human cytomegalovirus Human immunodeficiency virus Human papillomavirus Humans Infections Laboratories Lentivirus Male Medicine Medicine and Health Sciences Men Middle Aged Native North Americans Neisseria gonorrhoeae Ontario - epidemiology Papillomaviridae Papillomavirus Infections - complications Papillomavirus Infections - epidemiology People and Places Prevalence Public health Retroviridae Risk factors Serology Sex Sexual Behavior Sexual Partners Sexually transmitted diseases Sexually Transmitted Diseases - complications Sexually Transmitted Diseases - epidemiology STD Surveys and Questionnaires Syphilis Syphilis - complications Syphilis - epidemiology Treponema pallidum Urine Virus Diseases - complications Virus Diseases - epidemiology Viruses Womens health |
| title | Prevalence of Sexually Transmitted Viral and Bacterial Infections in HIV-Positive and HIV-Negative Men Who Have Sex with Men in Toronto |
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