The Reversal Effect and Its Mechanisms of Tetramethylpyrazine on Multidrug Resistance in Human Bladder Cancer

Chemotherapy is an important strategy for the treatment of bladder cancer. However, the main problem limiting the success of chemotherapy is the development of multidrug resistance (MDR). To improve the management of bladder cancer, it is an urgent matter to search for strategies to reverse MDR. We...

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Veröffentlicht in:	PloS one 2016-07, Vol.11 (7), p.e0157759-e0157759
Hauptverfasser:	Wang, Shanshan, Lei, Ting, Zhang, Man
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthracyclines Anticancer properties Antitumor agents ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Bcl-2 protein Biology and Life Sciences Bladder Bladder cancer Cancer Cancer therapies Catechin - analogs & derivatives Catechin - chemistry Cell Cycle Cell Line, Tumor Cell proliferation Cell Survival Chemotherapy Cholecystokinin Complications and side effects Cytometry Cytotoxicity Deoxyribonucleic acid DNA Dosage and administration Doxorubicin - chemistry Drug resistance Drug Resistance, Multiple Drug Resistance, Neoplasm Drug therapy Epigallocatechin gallate Epigallocatechin-3-gallate Flow Cytometry G1 phase Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Ginsenosides Herbal medicine Humans Laboratories Lung cancer Medicine Medicine and Health Sciences Metastasis mRNA Multidrug resistance Multidrug resistant organisms Neoplasm Proteins - genetics Polymerase chain reaction Proteins Pyrazines - chemistry Research and Analysis Methods S phase Tea Toxicity Tumors Urinary Bladder Neoplasms - drug therapy
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