Genome-wide Association Study Identifies Loci for the Polled Phenotype in Yak
The absence of horns, known as the polled phenotype, is an economically important trait in modern yak husbandry, but the genomic structure and genetic basis of this phenotype have yet to be discovered. Here, we conducted a genome-wide association study with a panel of 10 horned and 10 polled yaks us...
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| Veröffentlicht in: | PloS one 2016-07, Vol.11 (7), p.e0158642-e0158642 |
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| creator | Liang, Chunnian Wang, Lizhong Wu, Xiaoyun Wang, Kun Ding, Xuezhi Wang, Mingcheng Chu, Min Xie, Xiuyue Qiu, Qiang Yan, Ping |
| description | The absence of horns, known as the polled phenotype, is an economically important trait in modern yak husbandry, but the genomic structure and genetic basis of this phenotype have yet to be discovered. Here, we conducted a genome-wide association study with a panel of 10 horned and 10 polled yaks using whole genome sequencing. We mapped the POLLED locus to a 200-kb interval, which comprises three protein-coding genes. Further characterization of the candidate region showed recent artificial selection signals resulting from the breeding process. We suggest that expressional variations rather than structural variations in protein probably contribute to the polled phenotype. Our results not only represent the first and important step in establishing the genomic structure of the polled region in yak, but also add to our understanding of the polled trait in bovid species. |
| doi_str_mv | 10.1371/journal.pone.0158642 |
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Here, we conducted a genome-wide association study with a panel of 10 horned and 10 polled yaks using whole genome sequencing. We mapped the POLLED locus to a 200-kb interval, which comprises three protein-coding genes. Further characterization of the candidate region showed recent artificial selection signals resulting from the breeding process. We suggest that expressional variations rather than structural variations in protein probably contribute to the polled phenotype. Our results not only represent the first and important step in establishing the genomic structure of the polled region in yak, but also add to our understanding of the polled trait in bovid species.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0158642</identifier><identifier>PMID: 27389700</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Animal husbandry ; Animals ; Bioinformatics ; Biology and Life Sciences ; Bos taurus ; Bovidae ; Breeding ; Cattle ; Cattle - genetics ; Chromosome Mapping ; DNA sequencing ; Ecosystems ; Engineering ; Gene sequencing ; Genetic aspects ; Genetic Association Studies ; Genetic Variation ; Genetics ; Genetics, Population ; Genome ; Genome-wide association studies ; Genomes ; Genomics ; Genotype ; Grasslands ; Haplotypes ; Horns ; Laboratories ; Life sciences ; Linkage Disequilibrium ; Loci ; Mutation ; Pharmaceutical sciences ; Phenotype ; Phenotypes ; Phylogenetics ; Phylogeny ; Polymorphism, Single Nucleotide ; Population ; Research and Analysis Methods ; Yaks</subject><ispartof>PloS one, 2016-07, Vol.11 (7), p.e0158642-e0158642</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Liang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Liang et al 2016 Liang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-374ec45e4f37de8731bf19aa51fb98b47499dc231e5995cadc2861fca390ddab3</citedby><cites>FETCH-LOGICAL-c725t-374ec45e4f37de8731bf19aa51fb98b47499dc231e5995cadc2861fca390ddab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936749/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936749/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23847,27903,27904,53768,53770,79345,79346</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27389700$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>PENA i SUBIRÀ, Ramona Natacha</contributor><creatorcontrib>Liang, Chunnian</creatorcontrib><creatorcontrib>Wang, Lizhong</creatorcontrib><creatorcontrib>Wu, Xiaoyun</creatorcontrib><creatorcontrib>Wang, Kun</creatorcontrib><creatorcontrib>Ding, Xuezhi</creatorcontrib><creatorcontrib>Wang, Mingcheng</creatorcontrib><creatorcontrib>Chu, Min</creatorcontrib><creatorcontrib>Xie, Xiuyue</creatorcontrib><creatorcontrib>Qiu, Qiang</creatorcontrib><creatorcontrib>Yan, Ping</creatorcontrib><title>Genome-wide Association Study Identifies Loci for the Polled Phenotype in Yak</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The absence of horns, known as the polled phenotype, is an economically important trait in modern yak husbandry, but the genomic structure and genetic basis of this phenotype have yet to be discovered. Here, we conducted a genome-wide association study with a panel of 10 horned and 10 polled yaks using whole genome sequencing. We mapped the POLLED locus to a 200-kb interval, which comprises three protein-coding genes. Further characterization of the candidate region showed recent artificial selection signals resulting from the breeding process. We suggest that expressional variations rather than structural variations in protein probably contribute to the polled phenotype. Our results not only represent the first and important step in establishing the genomic structure of the polled region in yak, but also add to our understanding of the polled trait in bovid species.</description><subject>Analysis</subject><subject>Animal husbandry</subject><subject>Animals</subject><subject>Bioinformatics</subject><subject>Biology and Life Sciences</subject><subject>Bos taurus</subject><subject>Bovidae</subject><subject>Breeding</subject><subject>Cattle</subject><subject>Cattle - genetics</subject><subject>Chromosome Mapping</subject><subject>DNA sequencing</subject><subject>Ecosystems</subject><subject>Engineering</subject><subject>Gene sequencing</subject><subject>Genetic aspects</subject><subject>Genetic Association Studies</subject><subject>Genetic Variation</subject><subject>Genetics</subject><subject>Genetics, Population</subject><subject>Genome</subject><subject>Genome-wide association 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Here, we conducted a genome-wide association study with a panel of 10 horned and 10 polled yaks using whole genome sequencing. We mapped the POLLED locus to a 200-kb interval, which comprises three protein-coding genes. Further characterization of the candidate region showed recent artificial selection signals resulting from the breeding process. We suggest that expressional variations rather than structural variations in protein probably contribute to the polled phenotype. Our results not only represent the first and important step in establishing the genomic structure of the polled region in yak, but also add to our understanding of the polled trait in bovid species.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27389700</pmid><doi>10.1371/journal.pone.0158642</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Animal husbandry Animals Bioinformatics Biology and Life Sciences Bos taurus Bovidae Breeding Cattle Cattle - genetics Chromosome Mapping DNA sequencing Ecosystems Engineering Gene sequencing Genetic aspects Genetic Association Studies Genetic Variation Genetics Genetics, Population Genome Genome-wide association studies Genomes Genomics Genotype Grasslands Haplotypes Horns Laboratories Life sciences Linkage Disequilibrium Loci Mutation Pharmaceutical sciences Phenotype Phenotypes Phylogenetics Phylogeny Polymorphism, Single Nucleotide Population Research and Analysis Methods Yaks |
| title | Genome-wide Association Study Identifies Loci for the Polled Phenotype in Yak |
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