Mimp/Mtch2, an Obesity Susceptibility Gene, Induces Alteration of Fatty Acid Metabolism in Transgenic Mice
Metabolic dysfunctions, such as fatty liver, obesity and insulin resistance, are among the most common contemporary diseases worldwide, and their prevalence is continuously rising. Mimp/Mtch2 is a mitochondrial carrier protein homologue, which localizes to the mitochondria and induces mitochondrial...
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| creator | Bar-Lev, Yamit Moshitch-Moshkovitz, Sharon Tsarfaty, Galia Kaufman, Dafna Horev, Judith Resau, James H Tsarfaty, Ilan |
| description | Metabolic dysfunctions, such as fatty liver, obesity and insulin resistance, are among the most common contemporary diseases worldwide, and their prevalence is continuously rising. Mimp/Mtch2 is a mitochondrial carrier protein homologue, which localizes to the mitochondria and induces mitochondrial depolarization. Mimp/Mtch2 single-nucleotide polymorphism is associated with obesity in humans and its loss in mice muscle protects from obesity. Our aim was to study the effects of Mimp/Mtch2 overexpression in vivo.
Transgenic mice overexpressing Mimp/Mtch2-GFP were characterized and monitored for lipid accumulation, weight and blood glucose levels. Transgenic mice liver and kidneys were used for gene expression analysis.
Mimp/Mtch2-GFP transgenic mice express high levels of fatty acid synthase and of β-oxidation genes and develop fatty livers and kidneys. Moreover, high-fat diet-fed Mimp/Mtch2 mice exhibit high blood glucose levels. Our results also show that Mimp/Mtch2 is involved in lipid accumulation and uptake in cells and perhaps in human obesity.
Mimp/Mtch2 alters lipid metabolism and may play a role in the onset of obesity and development of insulin resistance. |
| doi_str_mv | 10.1371/journal.pone.0157850 |
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Transgenic mice overexpressing Mimp/Mtch2-GFP were characterized and monitored for lipid accumulation, weight and blood glucose levels. Transgenic mice liver and kidneys were used for gene expression analysis.
Mimp/Mtch2-GFP transgenic mice express high levels of fatty acid synthase and of β-oxidation genes and develop fatty livers and kidneys. Moreover, high-fat diet-fed Mimp/Mtch2 mice exhibit high blood glucose levels. Our results also show that Mimp/Mtch2 is involved in lipid accumulation and uptake in cells and perhaps in human obesity.
Mimp/Mtch2 alters lipid metabolism and may play a role in the onset of obesity and development of insulin resistance.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0157850</identifier><identifier>PMID: 27359329</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Accumulation ; Animals ; Biology and Life Sciences ; Blood ; Blood glucose ; Blood Glucose - metabolism ; Depolarization ; Diet, High-Fat ; Disease susceptibility ; Fatty Acid Synthases - genetics ; Fatty acid synthesis ; Fatty acids ; Fatty liver ; Fatty-acid synthase ; Gene expression ; Gene Expression Profiling - methods ; Gene Expression Regulation ; Genes ; Genetic aspects ; Genetic engineering ; Glucose ; High fat diet ; Homology ; Hyperglycemia ; In vivo methods and tests ; Insulin ; Insulin resistance ; Kidney - metabolism ; Kidney - pathology ; Kidneys ; Kinases ; Lipid Metabolism ; Liver ; Liver - metabolism ; Liver - pathology ; Medicine and Health Sciences ; Membrane Potential, Mitochondrial ; Metabolism ; Mice ; Mice, Transgenic ; Mitochondria ; Mitochondrial Membrane Transport Proteins - genetics ; Mitochondrial Membrane Transport Proteins - metabolism ; Muscles ; Obesity ; Obesity - genetics ; Oligonucleotide Array Sequence Analysis - methods ; Oxidation ; Polymorphism ; Research and Analysis Methods ; Rodents ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Transgenic mice ; Type 2 diabetes</subject><ispartof>PloS one, 2016-06, Vol.11 (6), p.e0157850-e0157850</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Bar-Lev et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Bar-Lev et al 2016 Bar-Lev et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-48f2ef3929a6df2be8d926dec0ceaeb8a22417a1bb5268b4590d037e8eb510763</citedby><cites>FETCH-LOGICAL-c725t-48f2ef3929a6df2be8d926dec0ceaeb8a22417a1bb5268b4590d037e8eb510763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928869/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928869/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27359329$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bar-Lev, Yamit</creatorcontrib><creatorcontrib>Moshitch-Moshkovitz, Sharon</creatorcontrib><creatorcontrib>Tsarfaty, Galia</creatorcontrib><creatorcontrib>Kaufman, Dafna</creatorcontrib><creatorcontrib>Horev, Judith</creatorcontrib><creatorcontrib>Resau, James H</creatorcontrib><creatorcontrib>Tsarfaty, Ilan</creatorcontrib><title>Mimp/Mtch2, an Obesity Susceptibility Gene, Induces Alteration of Fatty Acid Metabolism in Transgenic Mice</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Metabolic dysfunctions, such as fatty liver, obesity and insulin resistance, are among the most common contemporary diseases worldwide, and their prevalence is continuously rising. Mimp/Mtch2 is a mitochondrial carrier protein homologue, which localizes to the mitochondria and induces mitochondrial depolarization. Mimp/Mtch2 single-nucleotide polymorphism is associated with obesity in humans and its loss in mice muscle protects from obesity. Our aim was to study the effects of Mimp/Mtch2 overexpression in vivo.
Transgenic mice overexpressing Mimp/Mtch2-GFP were characterized and monitored for lipid accumulation, weight and blood glucose levels. Transgenic mice liver and kidneys were used for gene expression analysis.
Mimp/Mtch2-GFP transgenic mice express high levels of fatty acid synthase and of β-oxidation genes and develop fatty livers and kidneys. Moreover, high-fat diet-fed Mimp/Mtch2 mice exhibit high blood glucose levels. Our results also show that Mimp/Mtch2 is involved in lipid accumulation and uptake in cells and perhaps in human obesity.
Mimp/Mtch2 alters lipid metabolism and may play a role in the onset of obesity and development of insulin resistance.</description><subject>Accumulation</subject><subject>Animals</subject><subject>Biology and Life Sciences</subject><subject>Blood</subject><subject>Blood glucose</subject><subject>Blood Glucose - metabolism</subject><subject>Depolarization</subject><subject>Diet, High-Fat</subject><subject>Disease susceptibility</subject><subject>Fatty Acid Synthases - genetics</subject><subject>Fatty acid synthesis</subject><subject>Fatty acids</subject><subject>Fatty liver</subject><subject>Fatty-acid synthase</subject><subject>Gene expression</subject><subject>Gene Expression Profiling - methods</subject><subject>Gene Expression Regulation</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic engineering</subject><subject>Glucose</subject><subject>High fat diet</subject><subject>Homology</subject><subject>Hyperglycemia</subject><subject>In vivo methods and tests</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Kidney - metabolism</subject><subject>Kidney - pathology</subject><subject>Kidneys</subject><subject>Kinases</subject><subject>Lipid Metabolism</subject><subject>Liver</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Medicine and Health Sciences</subject><subject>Membrane Potential, Mitochondrial</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Mitochondria</subject><subject>Mitochondrial Membrane Transport Proteins - genetics</subject><subject>Mitochondrial Membrane Transport Proteins - metabolism</subject><subject>Muscles</subject><subject>Obesity</subject><subject>Obesity - genetics</subject><subject>Oligonucleotide Array Sequence Analysis - methods</subject><subject>Oxidation</subject><subject>Polymorphism</subject><subject>Research and Analysis Methods</subject><subject>Rodents</subject><subject>Single nucleotide polymorphisms</subject><subject>Single-nucleotide polymorphism</subject><subject>Transgenic mice</subject><subject>Type 2 diabetes</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk99r2zAQx83YWLtu_8HYDIOxQZNKsi3JL4NQ1i7QEFi7vQpZPicKspRa8lj_-8lNWuLRh6IH_bjPfXW60yXJe4ymOGP4bOP6zkoz3ToLU4QLxgv0IjnGZUYmlKDs5cH6KHnj_QahIuOUvk6OCMuKaCuPk81Ct9uzRVBrcppKmy4r8Drcpde9V7ANutJm2F6ChdN0butegU9nJkAng3Y2dU16IUMkZkrX6QKCrJzRvk21TW86af0KrFbpQit4m7xqpPHwbj-fJL8uvt-c_5hcLS_n57OriWKkCJOcNwSarCSlpHVDKuB1SWgNCimQUHFJSI6ZxFVVEMqrvChRjTIGHKoCI0azk-TjTndrnBf7NHmBOUIMcVaiSMx3RO3kRmw73cruTjipxf2B61ZCdkErA6JSjFKmgJG8yAtUl3GSGAAoyblCVdT6tr-tr1qoFdjQSTMSHVusXouV-yPyknBOyyjwZS_QudsefBCtjrk3Rlpw_X3cnJGS0uw5KM4zhFke0U__oU8nYk-tZHyrto2LIapBVMxyhhEucTFEOH2CiqOGVqv4_Rodz0cOX0cOkQnwN6xk772YX_98Prv8PWY_H7BrkCasvTP98BP9GMx3oOqc9x00j_XASAzd85ANMXSP2HdPdPtwWMtHp4d2yf4B2AoTMA</recordid><startdate>20160630</startdate><enddate>20160630</enddate><creator>Bar-Lev, Yamit</creator><creator>Moshitch-Moshkovitz, Sharon</creator><creator>Tsarfaty, Galia</creator><creator>Kaufman, Dafna</creator><creator>Horev, Judith</creator><creator>Resau, James H</creator><creator>Tsarfaty, Ilan</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20160630</creationdate><title>Mimp/Mtch2, an Obesity Susceptibility Gene, Induces Alteration of Fatty Acid Metabolism in Transgenic Mice</title><author>Bar-Lev, Yamit ; Moshitch-Moshkovitz, Sharon ; Tsarfaty, Galia ; Kaufman, Dafna ; Horev, Judith ; Resau, James H ; Tsarfaty, Ilan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c725t-48f2ef3929a6df2be8d926dec0ceaeb8a22417a1bb5268b4590d037e8eb510763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Accumulation</topic><topic>Animals</topic><topic>Biology and Life Sciences</topic><topic>Blood</topic><topic>Blood glucose</topic><topic>Blood Glucose - metabolism</topic><topic>Depolarization</topic><topic>Diet, High-Fat</topic><topic>Disease susceptibility</topic><topic>Fatty Acid Synthases - genetics</topic><topic>Fatty acid synthesis</topic><topic>Fatty acids</topic><topic>Fatty liver</topic><topic>Fatty-acid synthase</topic><topic>Gene expression</topic><topic>Gene Expression Profiling - methods</topic><topic>Gene Expression Regulation</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic engineering</topic><topic>Glucose</topic><topic>High fat diet</topic><topic>Homology</topic><topic>Hyperglycemia</topic><topic>In vivo methods and tests</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Kidney - metabolism</topic><topic>Kidney - pathology</topic><topic>Kidneys</topic><topic>Kinases</topic><topic>Lipid Metabolism</topic><topic>Liver</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Medicine and Health Sciences</topic><topic>Membrane Potential, Mitochondrial</topic><topic>Metabolism</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Mitochondria</topic><topic>Mitochondrial Membrane Transport Proteins - genetics</topic><topic>Mitochondrial Membrane Transport Proteins - metabolism</topic><topic>Muscles</topic><topic>Obesity</topic><topic>Obesity - genetics</topic><topic>Oligonucleotide Array Sequence Analysis - methods</topic><topic>Oxidation</topic><topic>Polymorphism</topic><topic>Research and Analysis Methods</topic><topic>Rodents</topic><topic>Single nucleotide polymorphisms</topic><topic>Single-nucleotide polymorphism</topic><topic>Transgenic mice</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bar-Lev, Yamit</creatorcontrib><creatorcontrib>Moshitch-Moshkovitz, Sharon</creatorcontrib><creatorcontrib>Tsarfaty, Galia</creatorcontrib><creatorcontrib>Kaufman, Dafna</creatorcontrib><creatorcontrib>Horev, Judith</creatorcontrib><creatorcontrib>Resau, James H</creatorcontrib><creatorcontrib>Tsarfaty, Ilan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Mimp/Mtch2 is a mitochondrial carrier protein homologue, which localizes to the mitochondria and induces mitochondrial depolarization. Mimp/Mtch2 single-nucleotide polymorphism is associated with obesity in humans and its loss in mice muscle protects from obesity. Our aim was to study the effects of Mimp/Mtch2 overexpression in vivo.
Transgenic mice overexpressing Mimp/Mtch2-GFP were characterized and monitored for lipid accumulation, weight and blood glucose levels. Transgenic mice liver and kidneys were used for gene expression analysis.
Mimp/Mtch2-GFP transgenic mice express high levels of fatty acid synthase and of β-oxidation genes and develop fatty livers and kidneys. Moreover, high-fat diet-fed Mimp/Mtch2 mice exhibit high blood glucose levels. Our results also show that Mimp/Mtch2 is involved in lipid accumulation and uptake in cells and perhaps in human obesity.
Mimp/Mtch2 alters lipid metabolism and may play a role in the onset of obesity and development of insulin resistance.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27359329</pmid><doi>10.1371/journal.pone.0157850</doi><tpages>e0157850</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1800708790 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Accumulation Animals Biology and Life Sciences Blood Blood glucose Blood Glucose - metabolism Depolarization Diet, High-Fat Disease susceptibility Fatty Acid Synthases - genetics Fatty acid synthesis Fatty acids Fatty liver Fatty-acid synthase Gene expression Gene Expression Profiling - methods Gene Expression Regulation Genes Genetic aspects Genetic engineering Glucose High fat diet Homology Hyperglycemia In vivo methods and tests Insulin Insulin resistance Kidney - metabolism Kidney - pathology Kidneys Kinases Lipid Metabolism Liver Liver - metabolism Liver - pathology Medicine and Health Sciences Membrane Potential, Mitochondrial Metabolism Mice Mice, Transgenic Mitochondria Mitochondrial Membrane Transport Proteins - genetics Mitochondrial Membrane Transport Proteins - metabolism Muscles Obesity Obesity - genetics Oligonucleotide Array Sequence Analysis - methods Oxidation Polymorphism Research and Analysis Methods Rodents Single nucleotide polymorphisms Single-nucleotide polymorphism Transgenic mice Type 2 diabetes |
| title | Mimp/Mtch2, an Obesity Susceptibility Gene, Induces Alteration of Fatty Acid Metabolism in Transgenic Mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T03%3A17%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mimp/Mtch2,%20an%20Obesity%20Susceptibility%20Gene,%20Induces%20Alteration%20of%20Fatty%20Acid%20Metabolism%20in%20Transgenic%20Mice&rft.jtitle=PloS%20one&rft.au=Bar-Lev,%20Yamit&rft.date=2016-06-30&rft.volume=11&rft.issue=6&rft.spage=e0157850&rft.epage=e0157850&rft.pages=e0157850-e0157850&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0157850&rft_dat=%3Cgale_plos_%3EA471019159%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1800708790&rft_id=info:pmid/27359329&rft_galeid=A471019159&rft_doaj_id=oai_doaj_org_article_bc7667ce7245450d9454a1eee6248c0b&rfr_iscdi=true |