Development of Patient Derived Xenograft Models of Overt Spontaneous Breast Cancer Metastasis: A Cautionary Note

Several approaches are being evaluated to improve the historically limited value of studying transplanted primary tumors derived by injection of cells from established cell lines for predicting subsequent cancer therapy outcomes in patients and clinical trials. These approaches include use of geneti...

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Veröffentlicht in:	PloS one 2016-06, Vol.11 (6), p.e0158034-e0158034
Hauptverfasser:	Paez-Ribes, Marta, Man, Shan, Xu, Ping, Kerbel, Robert S
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal models Animals Biology and Life Sciences Biotechnology Brain research Breast cancer Cancer Cancer metastasis Cancer therapies Cell Line, Tumor Chemotherapy Clinical trials Development and progression Disease Models, Animal Female Genetic engineering Health aspects Heterografts Historical account Humans Injection Lungs Medical research Medical treatment Medicine and Health Sciences Melanoma Metastases Metastasis Mice Mice, SCID Neoplasm Metastasis Neoplasm Transplantation Ostomy Patients Phenotype Phenotypes Research and Analysis Methods Skin cancer Therapy Transplantation Triple Negative Breast Neoplasms - pathology Tumor cell lines Tumor cells Tumors Xenografts Xenotransplantation
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