HMGB1-RAGE Axis Makes No Contribution to Cardiac Remodeling Induced by Pressure-Overload

High-mobility group box1 (HMGB1) exerts effects on inflammation by binding to receptor for advanced glycation end products (RAGE) or Toll-like receptor 4. Considering that inflammation is involved in pressure overload-induced cardiac hypertrophy, we herein attempted to investigate whether HMGB1 play...

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Veröffentlicht in:	PloS one 2016-06, Vol.11 (6), p.e0158514-e0158514
Hauptverfasser:	Lin, Hairuo, Shen, Liang, Zhang, Xiajun, Xie, Jiahe, Hao, Huixin, Zhang, Yingxue, Chen, Zhenhuan, Yamamoto, Hiroshi, Liao, Wangjun, Bin, Jianping, Cao, Shiping, Huang, Xiaobo, Liao, Yulin
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced glycosylation end products Animals Aorta Aorta - pathology Apoptosis BAX protein Binding Biology and Life Sciences Body weight Cardiology Cardiomegaly Cardiomyocytes Cell Survival Cells, Cultured Chromosomal proteins Comparative analysis DNA Damage Gene expression Genetic aspects Glycosylation Heart Heart diseases Heart failure Heart hypertrophy Histamine HMGB1 protein HMGB1 Protein - metabolism Homozygote Hypertrophy Immune system Inflammation Ischemia Laboratory animals Lungs Male Medicine and Health Sciences Mice Mice, Knockout mRNA Myocardium - metabolism Myocytes, Cardiac - cytology Neonates Organ Size Pressure Proteins Rats Receptor for Advanced Glycation End Products - metabolism Research and Analysis Methods Risk factors Rodents TLR4 protein Toll-Like Receptor 4 - metabolism Toll-like receptors
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