Evaluation of X Chromosome Inactivation with Respect to HLA Genetic Susceptibility in Rheumatoid Arthritis and Systemic Sclerosis

Autoimmune diseases, including rheumatoid arthritis (RA) and systemic sclerosis (SSc) are characterized by a strong genetic susceptibility from the Human Leucocyte Antigen (HLA) locus. Additionally, disorders of epigenetic processes, in particular non-random X chromosome inactivation (XCI), have bee...

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Veröffentlicht in:	PloS one 2016-06, Vol.11 (6), p.e0158550-e0158550
Hauptverfasser:	Kanaan, Sami B, Onat, Onur E, Balandraud, Nathalie, Martin, Gabriel V, Nelson, J Lee, Azzouz, Doua F, Auger, Isabelle, Arnoux, Fanny, Martin, Marielle, Roudier, Jean, Ozcelik, Tayfun, Lambert, Nathalie C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alleles Analysis Androgen receptors Arthritis Arthritis, Rheumatoid - genetics Autoantibodies Autoantibodies - blood Autoimmune diseases Biology and Life Sciences Blood Case-Control Studies Chromosomes Correlation Deactivation Disease Disease susceptibility DNA Methylation Drb1 protein Epigenesis, Genetic Epigenetics Epitopes Female Females Genes Genetic aspects Genetic Predisposition to Disease Genotype Genotyping Health risk assessment Histocompatibility antigen HLA HLA Antigens HLA-DQ beta-Chains - genetics HLA-DRB1 Chains - genetics Humans Immunoglobulins Immunology Inactivation Leukocytes (mononuclear) Leukocytes, Mononuclear - cytology Life Sciences Medical research Medicine and Health Sciences Middle Aged Molecular biology Mosaicism Patients People and Places Peripheral blood mononuclear cells Physiological aspects Pneumoviridae Polymorphism Receptors, Androgen - genetics Research and Analysis Methods Rheumatism Rheumatoid arthritis Rheumatology Scleroderma Scleroderma, Systemic - genetics Systemic sclerosis Womens health X chromosome X Chromosome Inactivation X chromosomes
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