Activation of AMP-Activated Protein Kinase and Stimulation of Energy Metabolism by Acetic Acid in L6 Myotube Cells

Previously, we found that orally administered acetic acid decreased lipogenesis in the liver and suppressed lipid accumulation in adipose tissue of Otsuka Long-Evans Tokushima Fatty rats, which exhibit hyperglycemic obesity with hyperinsulinemia and insulin resistance. Administered acetic acid led t...

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Veröffentlicht in:	PloS one 2016-06, Vol.11 (6), p.e0158055-e0158055
Hauptverfasser:	Maruta, Hitomi, Yoshimura, Yukihiro, Araki, Aya, Kimoto, Masumi, Takahashi, Yoshitaka, Yamashita, Hiromi
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Acetic acid Acetic Acid - pharmacology Acid resistance Adipose tissue AMP AMP-activated protein kinase AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Analysis Animals Bioaccumulation Biology and Life Sciences Cell culture Cell Line Diabetes Energy Metabolism Fatty acids Fatty Acids - metabolism Fitness training programs Gene expression Genes Glucose Glucose - metabolism Glucose transporter Glucose Transporter Type 4 - genetics Glucose Transporter Type 4 - metabolism Growth factors Hepatocytes Hyperinsulinemia Hypoxia Insulin Insulin resistance Kinases Lipid metabolism Lipids Lipogenesis Liver Medicine and Health Sciences MEF2 Transcription Factors - genetics MEF2 Transcription Factors - metabolism Metabolism Metabolites Muscle Fibers, Skeletal - drug effects Muscle Fibers, Skeletal - metabolism Muscles Musculoskeletal system Myoglobin Myoglobin - genetics Myoglobin - metabolism Myoglobins Obesity Oral administration Penicillin Phosphorylation Physical Sciences Physiological aspects Protein kinases Protein turnover Proteins Rats Research and Analysis Methods Rodents Science Skeletal muscle Stimulation Transcription factors Transporter Triglycerides - metabolism
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