In Vivo Assessment of Phage and Linezolid Based Implant Coatings for Treatment of Methicillin Resistant S. aureus (MRSA) Mediated Orthopaedic Device Related Infections

Staphylococcus comprises up to two-thirds of all pathogens in orthopaedic implant infections with two species respectively Staphylococcus aureus and Staphylococcus epidermidis, being the predominate etiological agents isolated. Further, with the emergence of methicillin-resistant S. aureus (MRSA), t...

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Veröffentlicht in:	PloS one 2016-06, Vol.11 (6), p.e0157626-e0157626
Hauptverfasser:	Kaur, Sandeep, Harjai, Kusum, Chhibber, Sanjay
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal models Animals Antibiotics Antimicrobial agents Bacteria Bacterial Load - drug effects Bacteriophages - metabolism Biofilms Biology and Life Sciences Biopolymers Calcitonin - metabolism Chronic fatigue syndrome Coated Materials, Biocompatible - pharmacology Coatings Complications and side effects Cytokines - metabolism Disease Models, Animal Dosage and administration Drug dosages Drug resistance Drug Resistance, Bacterial - drug effects Drug therapy Edema Edema - complications Edema - pathology Emergence Etiology Femur Health aspects Infections Inoculation Joint diseases Joint surgery Joints - diagnostic imaging Joints - microbiology Joints - pathology Joints - surgery Linezolid Linezolid - pharmacology Linezolid - therapeutic use Locomotion Medicine and Health Sciences Methicillin Methicillin-Resistant Staphylococcus aureus - drug effects Methylcellulose Motor Activity - drug effects Mutants Mutation - genetics Orthopedic appliances Orthopedic Equipment - microbiology Phages Prostheses Prostheses and Implants - adverse effects Prosthesis-Related Infections - drug therapy Prosthesis-Related Infections - microbiology Prosthesis-Related Infections - pathology Research and Analysis Methods Resistant mutant Staphylococcus aureus Staphylococcus aureus infections Staphylococcus epidermidis Staphylococcus infections Surgical implants Transplants & implants Wire Wound Healing - drug effects
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