Computational Intelligence Modeling of the Macromolecules Release from PLGA Microspheres-Focus on Feature Selection

Poly-lactide-co-glycolide (PLGA) is a copolymer of lactic and glycolic acid. Drug release from PLGA microspheres depends not only on polymer properties but also on drug type, particle size, morphology of microspheres, release conditions, etc. Selecting a subset of relevant properties for PLGA is a c...

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Veröffentlicht in:	PloS one 2016-06, Vol.11 (6), p.e0157610
Hauptverfasser:	Zawbaa, Hossam M, Szlȩk, Jakub, Grosan, Crina, Jachowicz, Renata, Mendyk, Aleksander
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive systems Algorithms Araneae Artificial Intelligence Artificial neural networks Biology and Life Sciences Classification Computer and Information Sciences Computer applications Computer science Curie, Marie (1867-1934) Dissolution Drug delivery systems Drug Liberation Engineering and Technology Errors Fuzzy logic Fuzzy systems Glycolic acid Humans Hybrid systems Intelligence International conferences Lactic Acid - chemistry Lactic Acid - therapeutic use Learning algorithms Machine learning Macromolecular Substances - chemistry Macromolecular Substances - therapeutic use Macromolecules Mathematical models Mathematical programming Microspheres Morphology Multiple objective analysis Neural networks Optimization Optimization algorithms Particle Size Pharmaceutical sciences Physical Sciences Polyglycolic Acid - chemistry Polyglycolic Acid - therapeutic use Polylactic Acid-Polyglycolic Acid Copolymer Polylactide-co-glycolide Polymers Polymers - chemistry Polymers - therapeutic use Prediction models Quality Regression analysis Research and Analysis Methods Splines
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