Association of Hepatitis B Virus Covalently Closed Circular DNA and Human APOBEC3B in Hepatitis B Virus-Related Hepatocellular Carcinoma

Chronic Hepatitis B Virus (HBV) infections can progresses to liver cirrhosis and hepatocellular carcinoma (HCC). The HBV covalently-closed circular DNA cccDNA is a key to HBV persistence, and its degradation can be induced by the cellular deaminase APOBEC3. This study aimed to measure the distributi...

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Veröffentlicht in:	PloS one 2016-06, Vol.11 (6), p.e0157708-e0157708
Hauptverfasser:	Luo, Xuan, Huang, Yao, Chen, Yanmeng, Tu, Zeng, Hu, Jieli, Tavis, John E, Huang, Ailong, Hu, Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Amplification Antigens, Viral - genetics Antigens, Viral - metabolism Biology and life sciences Carcinoma, Hepatocellular - enzymology Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - virology Case-Control Studies Circular DNA Cirrhosis Cytidine Deaminase - genetics Cytidine Deaminase - metabolism Degradation Deoxyribonucleic acid DNA DNA, Circular - chemistry DNA, Circular - genetics DNA, Circular - metabolism DNA, Viral - chemistry DNA, Viral - genetics DNA, Viral - metabolism Editing Education Gene Expression Genomes Hepatitis Hepatitis B Hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - metabolism Hepatitis B, Chronic - complications Hepatocellular carcinoma HIV Hospitals Host-Pathogen Interactions Human immunodeficiency virus Humans Hydrolysis Infections Infectious diseases Laboratories Liver Liver - enzymology Liver - pathology Liver - virology Liver cancer Liver cirrhosis Liver Neoplasms - enzymology Liver Neoplasms - genetics Liver Neoplasms - virology Male Medicine and health sciences Middle Aged Minor Histocompatibility Antigens - genetics Minor Histocompatibility Antigens - metabolism Molecular biology Mutagenesis Mutation Patients Proteins Research and Analysis Methods Tissues Transcription Virology Viruses
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