Statins Inhibit Fibrillary β-Amyloid Induced Inflammation in a Model of the Human Blood Brain Barrier

Astrocytes and cerebral endothelial cells are important components of the blood-brain barrier (BBB). Disruption to this barrier through inflammation is a major contributor to Alzheimer's disease (AD) pathology. The amyloid beta (Aβ) protein is known to exist in several forms and is a key modula...

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Veröffentlicht in:	PloS one 2016-06, Vol.11 (6), p.e0157483
Hauptverfasser:	Griffin, Jarred M, Kho, Dan, Graham, E Scott, Nicholson, Louise F B, O'Carroll, Simon J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - pharmacology Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anticholesteremic Agents - pharmacology Astrocytes Astrocytes - cytology Astrocytes - drug effects Astrocytes - metabolism Biology and Life Sciences Blood-brain barrier Blood-Brain Barrier - drug effects Brain research Cell death Cell Death - drug effects Cell Line Chemokine CCL2 - antagonists & inhibitors Chemokine CCL2 - metabolism Chemokine CCL5 - antagonists & inhibitors Chemokine CCL5 - metabolism Coculture Techniques Cytokines Cytotoxicity Endothelial cells Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - metabolism Gene expression Health sciences Homeostasis Humans Inflammation Interleukin-6 - antagonists & inhibitors Interleukin-6 - metabolism Interleukin-8 - antagonists & inhibitors Interleukin-8 - metabolism Kinases Lovastatin - pharmacology Medical imaging Medicine and Health Sciences Models, Biological Neurodegeneration Oxidative stress Pathology Peptide Fragments - antagonists & inhibitors Peptide Fragments - pharmacology Permeability Pharmacology Simvastatin - pharmacology Statins Toxicity Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - metabolism β-Amyloid
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