Increase in the Prevalence of Resistance Determinants to Trimethoprim/Sulfamethoxazole in Clinical Stenotrophomonas maltophilia Isolates in China

This study was carried to reveal the genetic mechanisms of trimethoprim/sulfamethoxazole (SXT) resistance. Among 300 clinical Stenotrophomonas maltophilia isolates from China, resistance determinants such as sul and dfrA genes, integrons and transposase were examined using PCR, DNA sequencing and th...

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Veröffentlicht in:	PloS one 2016-06, Vol.11 (6), p.e0157693-e0157693
Hauptverfasser:	Hu, Li-Fen, Chen, Guo-Sheng, Kong, Qin-Xiang, Gao, Li-Ping, Chen, Xi, Ye, Ying, Li, Jia-Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibiotics Antimicrobial agents Bacterial Proteins - genetics Bacterial Proteins - metabolism Biology and Life Sciences Cassettes China - epidemiology Data processing Deoxyribonucleic acid DNA DNA sequencing Drug Resistance, Multiple, Bacterial - genetics E coli Escherichia coli Gene Expression Regulation, Bacterial Gene sequencing Genes Genomes Genotype Gram-Negative Bacterial Infections - drug therapy Gram-Negative Bacterial Infections - epidemiology Gram-Negative Bacterial Infections - microbiology Hospitals Humans Infections Infectious diseases Integrase Integrases - genetics Integrases - metabolism Integrons Laboratories Logistic Models Medicine and Health Sciences Microbial Sensitivity Tests People and Places Physical Sciences Polymerase chain reaction Prevalence Quality control Regression analysis Research and Analysis Methods Sequence Analysis, DNA Stenotrophomonas maltophilia Stenotrophomonas maltophilia - classification Stenotrophomonas maltophilia - drug effects Stenotrophomonas maltophilia - genetics Stenotrophomonas maltophilia - isolation & purification Sulfamethoxazole Surveillance Transposase Transposases - genetics Transposases - metabolism Trimethoprim Trimethoprim, Sulfamethoxazole Drug Combination - pharmacology
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