Overexpression of Latent TGF[beta] Binding Protein 4 in Muscle Ameliorates Muscular Dystrophy through Myostatin and TGF[beta]

Latent TGF[beta] binding proteins (LTBPs) regulate the extracellular availability of latent TGF[beta]. LTBP4 was identified as a genetic modifier of muscular dystrophy in mice and humans. An in-frame insertion polymorphism in the murine Ltbp4 gene associates with partial protection against muscular...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	PLoS genetics 2016-05, Vol.12 (5)
Hauptverfasser:	Lamar, Kay-Marie, Bogdanovich, Sasha, Gardner, Brandon B, Gao, Quan Q, Miller, Tamari, Earley, Judy U, Hadhazy, Michele, Vo, Andy H, Wren, Lisa, Molkentin, Jeffery D, McNally, Elizabeth M
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding proteins Extracellular matrix Gene expression Genetic aspects Health aspects Immunoglobulins Laboratories Muscular dystrophy Mutation Phylogenetics Proteins Rodents Transforming growth factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!