Location, Location, Location: Five Facts about Tissue Tropism and Pathogenesis
[...]seasonal influenza viruses mainly infect the upper respiratory tract, while pandemic influenza as well as some highly pathogenic avian influenza viruses (e.g., H5N1) have increased ability to infect the lower respiratory tract [6]. [...]the increasing ease of genetic manipulation, including CRI...
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| Veröffentlicht in: | PLoS pathogens 2016-05, Vol.12 (5), p.e1005519-e1005519 |
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| creator | McCall, Laura-Isobel Siqueira-Neto, Jair L McKerrow, James H |
| description | [...]seasonal influenza viruses mainly infect the upper respiratory tract, while pandemic influenza as well as some highly pathogenic avian influenza viruses (e.g., H5N1) have increased ability to infect the lower respiratory tract [6]. [...]the increasing ease of genetic manipulation, including CRISPR/Cas9 technology, facilitates the necessary validation of the factors identified in these large-scale studies. [...]fine-scale differences in host tissue chemistry, metabolism, waste production, and local immune responses are still being identified. [...]while we usually know the ultimate tissue niche of a specific pathogen, we often do not understand the paths used to reach that location, as evidenced by the controversy surrounding the timing of brain penetration in T. brucei infection [4]. |
| doi_str_mv | 10.1371/journal.ppat.1005519 |
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[...]the increasing ease of genetic manipulation, including CRISPR/Cas9 technology, facilitates the necessary validation of the factors identified in these large-scale studies. [...]fine-scale differences in host tissue chemistry, metabolism, waste production, and local immune responses are still being identified. 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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: McCall L-I, Siqueira-Neto JL, McKerrow JH (2016) Location, Location, Location: Five Facts about Tissue Tropism and Pathogenesis. PLoS Pathog 12(5): e1005519. doi:10.1371/journal.ppat.1005519</rights><rights>2016 McCall et al 2016 McCall et al</rights><rights>2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: McCall L-I, Siqueira-Neto JL, McKerrow JH (2016) Location, Location, Location: Five Facts about Tissue Tropism and Pathogenesis. 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| subjects | Analysis Animals Biology and Life Sciences Care and treatment Disease transmission Fatalities Host-Pathogen Interactions - physiology Humans Infection - microbiology Medicine and Health Sciences Pandemics Parasites Pearls Risk factors Staphylococcus aureus infections Tropism - physiology Virulence (Microbiology) Viruses |
| title | Location, Location, Location: Five Facts about Tissue Tropism and Pathogenesis |
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