Maternal Early Pregnancy Serum Metabolomics Profile and Abnormal Vaginal Bleeding as Predictors of Placental Abruption: A Prospective Study

Placental abruption, an ischemic placental disorder, complicates about 1 in 100 pregnancies, and is an important cause of maternal and perinatal morbidity and mortality worldwide. Metabolomics holds promise for improving the phenotyping, prediction and understanding of pathophysiologic mechanisms of...

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Veröffentlicht in:	PloS one 2016-06, Vol.11 (6), p.e0156755-e0156755
Hauptverfasser:	Gelaye, Bizu, Sumner, Susan J, McRitchie, Susan, Carlson, James E, Ananth, Cande V, Enquobahrie, Daniel A, Qiu, Chunfang, Sorensen, Tanya K, Williams, Michelle A
Format:	Artikel
Sprache:	eng
Schlagworte:	Abruptio Placentae - blood Abruptio Placentae - etiology Abruptio Placentae - metabolism Adult Biology and Life Sciences Biomarkers Bleeding Chromatography Diabetes Diagnostic systems Epidemiology Fatty acids Female Gene expression Genomes Health risk assessment Humans Ionization Ischemia Laboratories Lecithin Liquid chromatography Mass spectrometry Mass spectroscopy Medical records Medicine and Health Sciences Metabolism Metabolites Metabolome Metabolomics Morbidity Odds Ratio Pathogenesis Performance prediction Phenotyping Phosphatidylcholine Placenta Preeclampsia Pregnancy Prospective Studies Public health Regression analysis Regression models ROC Curve Studies Uterine Hemorrhage - blood Uterine Hemorrhage - complications Uterine Hemorrhage - metabolism Vagina Womens health
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