Serum-Based Oxylipins Are Associated with Outcomes in Primary Prevention Implantable Cardioverter Defibrillator Patients

Individuals with systolic heart failure are at risk of ventricular arrhythmias and all-cause mortality. Little is known regarding the mechanisms underlying these events. We sought to better understand if oxylipins, a diverse class of lipid metabolites derived from the oxidation of polyunsaturated fa...

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Veröffentlicht in:	PloS one 2016-06, Vol.11 (6), p.e0157035-e0157035
Hauptverfasser:	Zhang, Yiyi, Guallar, Eliseo, Blasco-Colmenares, Elena, Harms, Amy C, Vreeken, Rob J, Hankemeier, Thomas, Tomaselli, Gordon F, Cheng, Alan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Analysis Arrhythmias, Cardiac - blood Arrhythmias, Cardiac - diagnosis Arrhythmias, Cardiac - etiology Biology and Life Sciences Biomarkers - blood Care and treatment Defibrillators Defibrillators, Implantable - adverse effects Diabetes Fatty acids Female Hazards Heart Heart diseases Heart failure Heart Failure - complications Heart Failure - therapy Humans Implantable cardioverter-defibrillators Kinases Male Medicine and Health Sciences Metabolites Middle Aged Mortality Oxidation Oxylipins - blood Patient outcomes Patients Physiological aspects Polyunsaturated fatty acids Predictive Value of Tests Prevention Primary Prevention - instrumentation Primary Prevention - methods Proportional Hazards Models Prospective Studies Risk Risk Assessment Rodents Statistical models Ventricle
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