Association between High Serum Homocysteine Levels and Biochemical Characteristics in Women with Polycystic Ovarian Syndrome: A Systematic Review and Meta-Analysis
Elevated homocysteine levels have been observed in previous studies of PCOS; however, the nature of the associations between high homocysteine levels and the biochemical characteristics of polycystic ovarian syndrome (PCOS)-such as obesity, insulin resistance (IR), and androgen levels-is still uncer...
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| description | Elevated homocysteine levels have been observed in previous studies of PCOS; however, the nature of the associations between high homocysteine levels and the biochemical characteristics of polycystic ovarian syndrome (PCOS)-such as obesity, insulin resistance (IR), and androgen levels-is still uncertain.
A systematic search was conducted electronically up to December 28, 2015 using specific eligibility criteria. Standardized mean difference (SMD) and the corresponding 95% confidence intervals (95% CIs) were used as a measure of effect size.
A total of 34 studies (with 1,718 cases and 1,399 controls) of homocysteine levels in PCOS were pooled in this meta-analysis. Significantly lower homocysteine levels were found in controls than in PCOS patients (SMD = 0.895, 95% CI = 0.643-1.146, P |
| doi_str_mv | 10.1371/journal.pone.0157389 |
| format | Article |
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A systematic search was conducted electronically up to December 28, 2015 using specific eligibility criteria. Standardized mean difference (SMD) and the corresponding 95% confidence intervals (95% CIs) were used as a measure of effect size.
A total of 34 studies (with 1,718 cases and 1,399 controls) of homocysteine levels in PCOS were pooled in this meta-analysis. Significantly lower homocysteine levels were found in controls than in PCOS patients (SMD = 0.895, 95% CI = 0.643-1.146, P<0.001; I2 = 90.4% and P<0.001 for heterogeneity), regardless of the degree of obesity, IR, or androgen levels. Homocysteine levels in non-IR PCOS patients were significantly lower than those of PCOS patients with IR (SMD = 0.69, 95% CI = 0.37-1.01, P<0.01; I2 = 0% and P = 0.50 for heterogeneity). However, metformin treatment did not appear to cause any significant change in the homocysteine levels of PCOS patients (SMD = -0.17, 95% CI = -1.10-0.75, P = 0.71; I2 = 92% and P<0.01 for heterogeneity).
High homocysteine levels in women with PCOS are not related to degree of obesity, IR, or androgen levels. Metformin treatment cannot decrease the homocysteine levels in PCOS patients.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0157389</identifier><identifier>PMID: 27281026</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Androgens - blood ; Biochemical characteristics ; Biochemistry ; Biology and Life Sciences ; Confidence intervals ; Development and progression ; Female ; Genetic aspects ; Health risk assessment ; Heterogeneity ; Homocysteine ; Homocysteine - blood ; Humans ; Insulin ; Insulin Resistance ; Measurement ; Medicine and Health Sciences ; Meta-analysis ; Metformin ; Obesity ; Obesity - blood ; Obesity - complications ; Patients ; Physical Sciences ; Physiological aspects ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - complications ; Research and Analysis Methods ; Studies ; Systematic review</subject><ispartof>PloS one, 2016-06, Vol.11 (6), p.e0157389-e0157389</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Meng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Meng et al 2016 Meng et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-9f3db5f70fd1a96dbb39f40e4238df76aaa3566b19994f2e5deb8414d6c3d8783</citedby><cites>FETCH-LOGICAL-c725t-9f3db5f70fd1a96dbb39f40e4238df76aaa3566b19994f2e5deb8414d6c3d8783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900592/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900592/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27281026$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meng, Yuming</creatorcontrib><creatorcontrib>Chen, Xiang</creatorcontrib><creatorcontrib>Peng, Zheng</creatorcontrib><creatorcontrib>Liu, Xuexiang</creatorcontrib><creatorcontrib>Sun, Yifan</creatorcontrib><creatorcontrib>Dai, Shengming</creatorcontrib><title>Association between High Serum Homocysteine Levels and Biochemical Characteristics in Women with Polycystic Ovarian Syndrome: A Systematic Review and Meta-Analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Elevated homocysteine levels have been observed in previous studies of PCOS; however, the nature of the associations between high homocysteine levels and the biochemical characteristics of polycystic ovarian syndrome (PCOS)-such as obesity, insulin resistance (IR), and androgen levels-is still uncertain.
A systematic search was conducted electronically up to December 28, 2015 using specific eligibility criteria. Standardized mean difference (SMD) and the corresponding 95% confidence intervals (95% CIs) were used as a measure of effect size.
A total of 34 studies (with 1,718 cases and 1,399 controls) of homocysteine levels in PCOS were pooled in this meta-analysis. Significantly lower homocysteine levels were found in controls than in PCOS patients (SMD = 0.895, 95% CI = 0.643-1.146, P<0.001; I2 = 90.4% and P<0.001 for heterogeneity), regardless of the degree of obesity, IR, or androgen levels. Homocysteine levels in non-IR PCOS patients were significantly lower than those of PCOS patients with IR (SMD = 0.69, 95% CI = 0.37-1.01, P<0.01; I2 = 0% and P = 0.50 for heterogeneity). However, metformin treatment did not appear to cause any significant change in the homocysteine levels of PCOS patients (SMD = -0.17, 95% CI = -1.10-0.75, P = 0.71; I2 = 92% and P<0.01 for heterogeneity).
High homocysteine levels in women with PCOS are not related to degree of obesity, IR, or androgen levels. Metformin treatment cannot decrease the homocysteine levels in PCOS patients.</description><subject>Analysis</subject><subject>Androgens - blood</subject><subject>Biochemical characteristics</subject><subject>Biochemistry</subject><subject>Biology and Life Sciences</subject><subject>Confidence intervals</subject><subject>Development and progression</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>Health risk assessment</subject><subject>Heterogeneity</subject><subject>Homocysteine</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>Measurement</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Metformin</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - complications</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Physiological aspects</subject><subject>Polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meng, Yuming</au><au>Chen, Xiang</au><au>Peng, Zheng</au><au>Liu, Xuexiang</au><au>Sun, Yifan</au><au>Dai, Shengming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between High Serum Homocysteine Levels and Biochemical Characteristics in Women with Polycystic Ovarian Syndrome: A Systematic Review and Meta-Analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-06-09</date><risdate>2016</risdate><volume>11</volume><issue>6</issue><spage>e0157389</spage><epage>e0157389</epage><pages>e0157389-e0157389</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Elevated homocysteine levels have been observed in previous studies of PCOS; however, the nature of the associations between high homocysteine levels and the biochemical characteristics of polycystic ovarian syndrome (PCOS)-such as obesity, insulin resistance (IR), and androgen levels-is still uncertain.
A systematic search was conducted electronically up to December 28, 2015 using specific eligibility criteria. Standardized mean difference (SMD) and the corresponding 95% confidence intervals (95% CIs) were used as a measure of effect size.
A total of 34 studies (with 1,718 cases and 1,399 controls) of homocysteine levels in PCOS were pooled in this meta-analysis. Significantly lower homocysteine levels were found in controls than in PCOS patients (SMD = 0.895, 95% CI = 0.643-1.146, P<0.001; I2 = 90.4% and P<0.001 for heterogeneity), regardless of the degree of obesity, IR, or androgen levels. Homocysteine levels in non-IR PCOS patients were significantly lower than those of PCOS patients with IR (SMD = 0.69, 95% CI = 0.37-1.01, P<0.01; I2 = 0% and P = 0.50 for heterogeneity). However, metformin treatment did not appear to cause any significant change in the homocysteine levels of PCOS patients (SMD = -0.17, 95% CI = -1.10-0.75, P = 0.71; I2 = 92% and P<0.01 for heterogeneity).
High homocysteine levels in women with PCOS are not related to degree of obesity, IR, or androgen levels. Metformin treatment cannot decrease the homocysteine levels in PCOS patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27281026</pmid><doi>10.1371/journal.pone.0157389</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Androgens - blood Biochemical characteristics Biochemistry Biology and Life Sciences Confidence intervals Development and progression Female Genetic aspects Health risk assessment Heterogeneity Homocysteine Homocysteine - blood Humans Insulin Insulin Resistance Measurement Medicine and Health Sciences Meta-analysis Metformin Obesity Obesity - blood Obesity - complications Patients Physical Sciences Physiological aspects Polycystic ovary syndrome Polycystic Ovary Syndrome - blood Polycystic Ovary Syndrome - complications Research and Analysis Methods Studies Systematic review |
| title | Association between High Serum Homocysteine Levels and Biochemical Characteristics in Women with Polycystic Ovarian Syndrome: A Systematic Review and Meta-Analysis |
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