The Protein Kinase CK2 Mediates Cross-Talk between Auxin- and Salicylic Acid-Signaling Pathways in the Regulation of PINOID Transcription
The protein kinase CK2 is a ubiquitous and highly conserved enzyme, the activity of which is vital for eukaryotic cells. We recently demonstrated that CK2 modulates salicylic acid (SA) homeostasis in Arabidopsis thaliana, and that functional interplay between CK2 and SA sustains transcriptional expr...
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| description | The protein kinase CK2 is a ubiquitous and highly conserved enzyme, the activity of which is vital for eukaryotic cells. We recently demonstrated that CK2 modulates salicylic acid (SA) homeostasis in Arabidopsis thaliana, and that functional interplay between CK2 and SA sustains transcriptional expression of PIN-FORMED (PIN) genes. In this work, we show that CK2 also plays a key role in the transcriptional regulation of PINOID (PID), an AGC protein kinase that modulates the apical/basal localization of auxin-efflux transporters. We show that PID transcription is up-regulated by auxin and by SA and that CK2 is involved in both pathways. On the one hand, CK2 activity is required for proteosome-dependent degradation of AXR3, a member of the AUX/IAA family of auxin transcriptional repressors that must be degraded to activate auxin-responsive gene expression. On the other hand, the role of CK2 in SA homeostasis and, indirectly, in SA-driven PID transcription, was confirmed by using Arabidopsis NahG transgenic plants, which cannot accumulate SA. In conclusion, our results evidence a role for CK2 as a functional link in the negative cross-talk between auxin- and SA-signaling. |
| doi_str_mv | 10.1371/journal.pone.0157168 |
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We recently demonstrated that CK2 modulates salicylic acid (SA) homeostasis in Arabidopsis thaliana, and that functional interplay between CK2 and SA sustains transcriptional expression of PIN-FORMED (PIN) genes. In this work, we show that CK2 also plays a key role in the transcriptional regulation of PINOID (PID), an AGC protein kinase that modulates the apical/basal localization of auxin-efflux transporters. We show that PID transcription is up-regulated by auxin and by SA and that CK2 is involved in both pathways. On the one hand, CK2 activity is required for proteosome-dependent degradation of AXR3, a member of the AUX/IAA family of auxin transcriptional repressors that must be degraded to activate auxin-responsive gene expression. On the other hand, the role of CK2 in SA homeostasis and, indirectly, in SA-driven PID transcription, was confirmed by using Arabidopsis NahG transgenic plants, which cannot accumulate SA. In conclusion, our results evidence a role for CK2 as a functional link in the negative cross-talk between auxin- and SA-signaling.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0157168</identifier><identifier>PMID: 27275924</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acids ; Arabidopsis ; Arabidopsis - genetics ; Arabidopsis - metabolism ; Arabidopsis Proteins - biosynthesis ; Arabidopsis Proteins - genetics ; Arabidopsis thaliana ; Biology and Life Sciences ; Casein kinase II ; Casein Kinase II - genetics ; Casein Kinase II - metabolism ; Crosstalk ; Drug resistance ; Efflux ; Ethanol ; Flowers & plants ; Gene expression ; Gene Expression Regulation, Enzymologic - physiology ; Gene Expression Regulation, Plant - physiology ; Gene regulation ; Genetic aspects ; Homeostasis ; Indoleacetic acid ; Indoleacetic Acids - metabolism ; Kinases ; Life Sciences ; Localization ; Mixed Function Oxygenases - biosynthesis ; Mixed Function Oxygenases - genetics ; Nuclear Proteins - biosynthesis ; Nuclear Proteins - genetics ; Phosphorylation ; Physiological aspects ; Plants, Genetically Modified - genetics ; Plants, Genetically Modified - metabolism ; Plasma ; Protein kinase C ; Protein kinases ; Protein-Serine-Threonine Kinases - biosynthesis ; Protein-Serine-Threonine Kinases - genetics ; Proteins ; Repressors ; Research and Analysis Methods ; Salicylic acid ; Salicylic Acid - metabolism ; Signal transduction ; Signal Transduction - physiology ; Signaling ; Transcription (Genetics) ; Transcription factors ; Transcription, Genetic - physiology ; Transgenic plants ; Up-Regulation - physiology</subject><ispartof>PloS one, 2016-06, Vol.11 (6), p.e0157168-e0157168</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Armengot et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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In conclusion, our results evidence a role for CK2 as a functional link in the negative cross-talk between auxin- and SA-signaling.</description><subject>Acids</subject><subject>Arabidopsis</subject><subject>Arabidopsis - genetics</subject><subject>Arabidopsis - metabolism</subject><subject>Arabidopsis Proteins - biosynthesis</subject><subject>Arabidopsis Proteins - genetics</subject><subject>Arabidopsis thaliana</subject><subject>Biology and Life Sciences</subject><subject>Casein kinase II</subject><subject>Casein Kinase II - genetics</subject><subject>Casein Kinase II - metabolism</subject><subject>Crosstalk</subject><subject>Drug resistance</subject><subject>Efflux</subject><subject>Ethanol</subject><subject>Flowers & plants</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Enzymologic - physiology</subject><subject>Gene Expression Regulation, Plant - physiology</subject><subject>Gene regulation</subject><subject>Genetic aspects</subject><subject>Homeostasis</subject><subject>Indoleacetic acid</subject><subject>Indoleacetic Acids - metabolism</subject><subject>Kinases</subject><subject>Life Sciences</subject><subject>Localization</subject><subject>Mixed Function Oxygenases - biosynthesis</subject><subject>Mixed Function Oxygenases - genetics</subject><subject>Nuclear Proteins - biosynthesis</subject><subject>Nuclear Proteins - genetics</subject><subject>Phosphorylation</subject><subject>Physiological aspects</subject><subject>Plants, Genetically Modified - genetics</subject><subject>Plants, Genetically Modified - metabolism</subject><subject>Plasma</subject><subject>Protein kinase C</subject><subject>Protein kinases</subject><subject>Protein-Serine-Threonine Kinases - biosynthesis</subject><subject>Protein-Serine-Threonine Kinases - genetics</subject><subject>Proteins</subject><subject>Repressors</subject><subject>Research and Analysis Methods</subject><subject>Salicylic acid</subject><subject>Salicylic Acid - metabolism</subject><subject>Signal transduction</subject><subject>Signal Transduction - physiology</subject><subject>Signaling</subject><subject>Transcription (Genetics)</subject><subject>Transcription factors</subject><subject>Transcription, Genetic - 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genetics</topic><topic>Arabidopsis - metabolism</topic><topic>Arabidopsis Proteins - biosynthesis</topic><topic>Arabidopsis Proteins - genetics</topic><topic>Arabidopsis thaliana</topic><topic>Biology and Life Sciences</topic><topic>Casein kinase II</topic><topic>Casein Kinase II - genetics</topic><topic>Casein Kinase II - metabolism</topic><topic>Crosstalk</topic><topic>Drug resistance</topic><topic>Efflux</topic><topic>Ethanol</topic><topic>Flowers & plants</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Enzymologic - physiology</topic><topic>Gene Expression Regulation, Plant - physiology</topic><topic>Gene regulation</topic><topic>Genetic aspects</topic><topic>Homeostasis</topic><topic>Indoleacetic acid</topic><topic>Indoleacetic Acids - metabolism</topic><topic>Kinases</topic><topic>Life Sciences</topic><topic>Localization</topic><topic>Mixed Function Oxygenases - biosynthesis</topic><topic>Mixed Function Oxygenases - genetics</topic><topic>Nuclear Proteins - 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Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Armengot, Laia</au><au>Caldarella, Eleonora</au><au>Marquès-Bueno, Maria Mar</au><au>Martínez, M Carmen</au><au>Rahman, Abidur</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Protein Kinase CK2 Mediates Cross-Talk between Auxin- and Salicylic Acid-Signaling Pathways in the Regulation of PINOID Transcription</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-06-08</date><risdate>2016</risdate><volume>11</volume><issue>6</issue><spage>e0157168</spage><epage>e0157168</epage><pages>e0157168-e0157168</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The protein kinase CK2 is a ubiquitous and highly conserved enzyme, the activity of which is vital for eukaryotic cells. We recently demonstrated that CK2 modulates salicylic acid (SA) homeostasis in Arabidopsis thaliana, and that functional interplay between CK2 and SA sustains transcriptional expression of PIN-FORMED (PIN) genes. In this work, we show that CK2 also plays a key role in the transcriptional regulation of PINOID (PID), an AGC protein kinase that modulates the apical/basal localization of auxin-efflux transporters. We show that PID transcription is up-regulated by auxin and by SA and that CK2 is involved in both pathways. On the one hand, CK2 activity is required for proteosome-dependent degradation of AXR3, a member of the AUX/IAA family of auxin transcriptional repressors that must be degraded to activate auxin-responsive gene expression. On the other hand, the role of CK2 in SA homeostasis and, indirectly, in SA-driven PID transcription, was confirmed by using Arabidopsis NahG transgenic plants, which cannot accumulate SA. In conclusion, our results evidence a role for CK2 as a functional link in the negative cross-talk between auxin- and SA-signaling.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27275924</pmid><doi>10.1371/journal.pone.0157168</doi><tpages>e0157168</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acids Arabidopsis Arabidopsis - genetics Arabidopsis - metabolism Arabidopsis Proteins - biosynthesis Arabidopsis Proteins - genetics Arabidopsis thaliana Biology and Life Sciences Casein kinase II Casein Kinase II - genetics Casein Kinase II - metabolism Crosstalk Drug resistance Efflux Ethanol Flowers & plants Gene expression Gene Expression Regulation, Enzymologic - physiology Gene Expression Regulation, Plant - physiology Gene regulation Genetic aspects Homeostasis Indoleacetic acid Indoleacetic Acids - metabolism Kinases Life Sciences Localization Mixed Function Oxygenases - biosynthesis Mixed Function Oxygenases - genetics Nuclear Proteins - biosynthesis Nuclear Proteins - genetics Phosphorylation Physiological aspects Plants, Genetically Modified - genetics Plants, Genetically Modified - metabolism Plasma Protein kinase C Protein kinases Protein-Serine-Threonine Kinases - biosynthesis Protein-Serine-Threonine Kinases - genetics Proteins Repressors Research and Analysis Methods Salicylic acid Salicylic Acid - metabolism Signal transduction Signal Transduction - physiology Signaling Transcription (Genetics) Transcription factors Transcription, Genetic - physiology Transgenic plants Up-Regulation - physiology |
| title | The Protein Kinase CK2 Mediates Cross-Talk between Auxin- and Salicylic Acid-Signaling Pathways in the Regulation of PINOID Transcription |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T12%3A38%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Protein%20Kinase%20CK2%20Mediates%20Cross-Talk%20between%20Auxin-%20and%20Salicylic%20Acid-Signaling%20Pathways%20in%20the%20Regulation%20of%20PINOID%20Transcription&rft.jtitle=PloS%20one&rft.au=Armengot,%20Laia&rft.date=2016-06-08&rft.volume=11&rft.issue=6&rft.spage=e0157168&rft.epage=e0157168&rft.pages=e0157168-e0157168&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0157168&rft_dat=%3Cgale_plos_%3EA454562847%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1794824591&rft_id=info:pmid/27275924&rft_galeid=A454562847&rft_doaj_id=oai_doaj_org_article_38a944aa3c0349d585d6898e2f652c41&rfr_iscdi=true |