Association between Interferon Response and Protective Efficacy of NS1-Truncated Mutants as Influenza Vaccine Candidates in Chickens

Influenza virus mutants that encode C-terminally truncated NS1 proteins (NS1-truncated mutants) are attractive candidates for avian live attenuated influenza vaccine (LAIV) development because they are both attenuated and immunogenic in chickens. We previously showed that a high protective efficacy...

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Veröffentlicht in:	PloS one 2016-06, Vol.11 (6), p.e0156603-e0156603
Hauptverfasser:	Jang, Hyesun, Ngunjiri, John M, Lee, Chang-Won
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Administration, Oral Animals Antibodies, Viral - blood Biology and Life Sciences Chickens Drinking water Economic aspects Effectiveness Embryo fibroblasts Genetic aspects Health aspects Immune response Immunogenicity Influence Influenza Influenza in Birds - prevention & control Influenza in Birds - virology Influenza vaccines Influenza Vaccines - immunology Influenza virus Interferon Interferons - immunology Interferons - pharmacology Medicine and Health Sciences Mutants Mutation Oral administration Orthomyxoviridae Pandemics Poultry Poultry industry Preventive medicine Proteins Recombinant Proteins - immunology Vaccines Vaccines, Attenuated - immunology Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - immunology Viruses
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