Soluble DNAM-1, as a Predictive Biomarker for Acute Graft-Versus-Host Disease

Acute graft-versus-host disease (aGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Because diagnosis of aGVHD is exclusively based on clinical symptoms and pathological findings, reliable and noninvasive laboratory tests for accurate diagnosis are requ...

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Veröffentlicht in:PloS one 2016-06, Vol.11 (6), p.e0154173-e0154173
Hauptverfasser: Kanaya, Minoru, Shibuya, Kazuko, Hirochika, Rei, Kanemoto, Miyoko, Ohashi, Kazuteru, Okada, Masafumi, Wagatsuma, Yukiko, Cho, Yukiko, Kojima, Hiroshi, Teshima, Takanori, Imamura, Masahiro, Sakamaki, Hisashi, Shibuya, Akira
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container_title PloS one
container_volume 11
creator Kanaya, Minoru
Shibuya, Kazuko
Hirochika, Rei
Kanemoto, Miyoko
Ohashi, Kazuteru
Okada, Masafumi
Wagatsuma, Yukiko
Cho, Yukiko
Kojima, Hiroshi
Teshima, Takanori
Imamura, Masahiro
Sakamaki, Hisashi
Shibuya, Akira
description Acute graft-versus-host disease (aGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Because diagnosis of aGVHD is exclusively based on clinical symptoms and pathological findings, reliable and noninvasive laboratory tests for accurate diagnosis are required. An activating immunoreceptor, DNAM-1 (CD226), is expressed on T cells and natural killer cells and is involved in the development of aGVHD. Here, we identified a soluble form of DNAM-1 (sDNAM-1) in human sera. In retrospective univariate and multivariate analyses of allo-HSCT patients (n = 71) at a single center, cumulative incidences of all grade (grade I-IV) and sgrade II-IV aGVHD in patients with high maximal serum levels of sDNAM-1 (≥30 pM) in the 7 days before allo-HSCT were significantly higher than those in patients with low maximal serum levels of sDNAM-1 (
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subjects Analysis
Antigens, Differentiation, T-Lymphocyte - blood
Biology and Life Sciences
Biomarkers - blood
Complications and side effects
Female
Graft versus host disease
Graft vs Host Disease - blood
Graft vs Host Disease - diagnosis
Graft vs Host Disease - etiology
Graft vs. host disease
Hematopoietic stem cell transplantation
Hematopoietic Stem Cell Transplantation - adverse effects
Humans
Killer cells
Leukemia, Myeloid, Acute - therapy
Male
Medicine and Health Sciences
Middle Aged
Myelodysplastic Syndromes - therapy
Physical Sciences
Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy
Research and Analysis Methods
Retrospective Studies
Risk factors
T cells
Transplantation, Homologous - adverse effects
Treatment Outcome
title Soluble DNAM-1, as a Predictive Biomarker for Acute Graft-Versus-Host Disease
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