Soluble DNAM-1, as a Predictive Biomarker for Acute Graft-Versus-Host Disease
Acute graft-versus-host disease (aGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Because diagnosis of aGVHD is exclusively based on clinical symptoms and pathological findings, reliable and noninvasive laboratory tests for accurate diagnosis are requ...
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creator | Kanaya, Minoru Shibuya, Kazuko Hirochika, Rei Kanemoto, Miyoko Ohashi, Kazuteru Okada, Masafumi Wagatsuma, Yukiko Cho, Yukiko Kojima, Hiroshi Teshima, Takanori Imamura, Masahiro Sakamaki, Hisashi Shibuya, Akira |
description | Acute graft-versus-host disease (aGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Because diagnosis of aGVHD is exclusively based on clinical symptoms and pathological findings, reliable and noninvasive laboratory tests for accurate diagnosis are required. An activating immunoreceptor, DNAM-1 (CD226), is expressed on T cells and natural killer cells and is involved in the development of aGVHD. Here, we identified a soluble form of DNAM-1 (sDNAM-1) in human sera. In retrospective univariate and multivariate analyses of allo-HSCT patients (n = 71) at a single center, cumulative incidences of all grade (grade I-IV) and sgrade II-IV aGVHD in patients with high maximal serum levels of sDNAM-1 (≥30 pM) in the 7 days before allo-HSCT were significantly higher than those in patients with low maximal serum levels of sDNAM-1 ( |
doi_str_mv | 10.1371/journal.pone.0154173 |
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Because diagnosis of aGVHD is exclusively based on clinical symptoms and pathological findings, reliable and noninvasive laboratory tests for accurate diagnosis are required. An activating immunoreceptor, DNAM-1 (CD226), is expressed on T cells and natural killer cells and is involved in the development of aGVHD. Here, we identified a soluble form of DNAM-1 (sDNAM-1) in human sera. In retrospective univariate and multivariate analyses of allo-HSCT patients (n = 71) at a single center, cumulative incidences of all grade (grade I-IV) and sgrade II-IV aGVHD in patients with high maximal serum levels of sDNAM-1 (≥30 pM) in the 7 days before allo-HSCT were significantly higher than those in patients with low maximal serum levels of sDNAM-1 (<30 pM) in the same period. However, sDNAM-1 was not associated with other known allo-HSCT complications. Our data suggest that sDNAM-1 is potentially a unique candidate as a predictive biomarker for the development of aGVHD.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0154173</identifier><identifier>PMID: 27257974</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Antigens, Differentiation, T-Lymphocyte - blood ; Biology and Life Sciences ; Biomarkers - blood ; Complications and side effects ; Female ; Graft versus host disease ; Graft vs Host Disease - blood ; Graft vs Host Disease - diagnosis ; Graft vs Host Disease - etiology ; Graft vs. host disease ; Hematopoietic stem cell transplantation ; Hematopoietic Stem Cell Transplantation - adverse effects ; Humans ; Killer cells ; Leukemia, Myeloid, Acute - therapy ; Male ; Medicine and Health Sciences ; Middle Aged ; Myelodysplastic Syndromes - therapy ; Physical Sciences ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy ; Research and Analysis Methods ; Retrospective Studies ; Risk factors ; T cells ; Transplantation, Homologous - adverse effects ; Treatment Outcome</subject><ispartof>PloS one, 2016-06, Vol.11 (6), p.e0154173-e0154173</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Kanaya et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Kanaya et al 2016 Kanaya et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c769t-3ba22de5a4a872f9ae092ee9ecb083986e513aa447d25a86b9b9786b984f9ba73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892670/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892670/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27257974$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Palaniyandi, Senthilnathan</contributor><creatorcontrib>Kanaya, Minoru</creatorcontrib><creatorcontrib>Shibuya, Kazuko</creatorcontrib><creatorcontrib>Hirochika, Rei</creatorcontrib><creatorcontrib>Kanemoto, Miyoko</creatorcontrib><creatorcontrib>Ohashi, Kazuteru</creatorcontrib><creatorcontrib>Okada, Masafumi</creatorcontrib><creatorcontrib>Wagatsuma, Yukiko</creatorcontrib><creatorcontrib>Cho, Yukiko</creatorcontrib><creatorcontrib>Kojima, Hiroshi</creatorcontrib><creatorcontrib>Teshima, Takanori</creatorcontrib><creatorcontrib>Imamura, Masahiro</creatorcontrib><creatorcontrib>Sakamaki, Hisashi</creatorcontrib><creatorcontrib>Shibuya, Akira</creatorcontrib><title>Soluble DNAM-1, as a Predictive Biomarker for Acute Graft-Versus-Host Disease</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Acute graft-versus-host disease (aGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Because diagnosis of aGVHD is exclusively based on clinical symptoms and pathological findings, reliable and noninvasive laboratory tests for accurate diagnosis are required. An activating immunoreceptor, DNAM-1 (CD226), is expressed on T cells and natural killer cells and is involved in the development of aGVHD. Here, we identified a soluble form of DNAM-1 (sDNAM-1) in human sera. In retrospective univariate and multivariate analyses of allo-HSCT patients (n = 71) at a single center, cumulative incidences of all grade (grade I-IV) and sgrade II-IV aGVHD in patients with high maximal serum levels of sDNAM-1 (≥30 pM) in the 7 days before allo-HSCT were significantly higher than those in patients with low maximal serum levels of sDNAM-1 (<30 pM) in the same period. However, sDNAM-1 was not associated with other known allo-HSCT complications. 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Because diagnosis of aGVHD is exclusively based on clinical symptoms and pathological findings, reliable and noninvasive laboratory tests for accurate diagnosis are required. An activating immunoreceptor, DNAM-1 (CD226), is expressed on T cells and natural killer cells and is involved in the development of aGVHD. Here, we identified a soluble form of DNAM-1 (sDNAM-1) in human sera. In retrospective univariate and multivariate analyses of allo-HSCT patients (n = 71) at a single center, cumulative incidences of all grade (grade I-IV) and sgrade II-IV aGVHD in patients with high maximal serum levels of sDNAM-1 (≥30 pM) in the 7 days before allo-HSCT were significantly higher than those in patients with low maximal serum levels of sDNAM-1 (<30 pM) in the same period. However, sDNAM-1 was not associated with other known allo-HSCT complications. Our data suggest that sDNAM-1 is potentially a unique candidate as a predictive biomarker for the development of aGVHD.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27257974</pmid><doi>10.1371/journal.pone.0154173</doi><oa>free_for_read</oa></addata></record> |
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subjects | Analysis Antigens, Differentiation, T-Lymphocyte - blood Biology and Life Sciences Biomarkers - blood Complications and side effects Female Graft versus host disease Graft vs Host Disease - blood Graft vs Host Disease - diagnosis Graft vs Host Disease - etiology Graft vs. host disease Hematopoietic stem cell transplantation Hematopoietic Stem Cell Transplantation - adverse effects Humans Killer cells Leukemia, Myeloid, Acute - therapy Male Medicine and Health Sciences Middle Aged Myelodysplastic Syndromes - therapy Physical Sciences Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy Research and Analysis Methods Retrospective Studies Risk factors T cells Transplantation, Homologous - adverse effects Treatment Outcome |
title | Soluble DNAM-1, as a Predictive Biomarker for Acute Graft-Versus-Host Disease |
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