Alpha 1 Antitrypsin Inhibits Dendritic Cell Activation and Attenuates Nephritis in a Mouse Model of Lupus

Systemic lupus erythematosus (SLE) is an autoimmune disorder with a worldwide distribution and considerable mortality and morbidity. Although the pathogenesis of this disease remains elusive, over-reactive dendritic cells (DCs) play a critical role in the disease development. It has been shown that...

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Veröffentlicht in:	PloS one 2016-05, Vol.11 (5), p.e0156583-e0156583
Hauptverfasser:	Elshikha, Ahmed S, Lu, Yuanqing, Chen, Mong-Jen, Akbar, Mohammad, Zeumer, Leilani, Ritter, Andrea, Elghamry, Hanaa, Mahdi, Mahmoud A, Morel, Laurence, Song, Sihong
Format:	Artikel
Sprache:	eng
Schlagworte:	Alpha 1-antitrypsin alpha 1-Antitrypsin - pharmacology Animal models Animals Arthritis Attenuation Autoantibodies Autoantibodies - biosynthesis Autoimmune diseases Autoimmunity Biology and Life Sciences Bone marrow Bone Marrow Cells - cytology Care and treatment Cell activation Cell Differentiation - drug effects Chronic conditions Complications and side effects CpG islands Cytokines Cytokines - biosynthesis Cytokines - metabolism Dendritic cells Dendritic Cells - cytology Dendritic Cells - drug effects Diabetes mellitus Diabetes mellitus (insulin dependent) Differentiation Disease Models, Animal Disease Progression Dosage and administration Drug therapy Female Gene Expression Regulation - drug effects Health aspects Humans IL-1β Immunology Inflammation Interferon Laboratories Lipopolysaccharides Lupus Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - metabolism Lymphocytes Male Medical research Medicine and Health Sciences Mice Morbidity Nephritis Neutrophils Pathogenesis Pharmaceutical sciences Pharmacy Proteins Research and Analysis Methods Rheumatoid arthritis Risk factors Systemic lupus erythematosus TLR4 protein TLR9 protein Toll-like receptors Tumor necrosis factor-α
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