MRI Based Localisation and Quantification of Abscesses following Experimental S. aureus Intravenous Challenge: Application to Vaccine Evaluation

To develop and validate a sensitive and specific method of abscess enumeration and quantification in a preclinical model of Staphylococcus aureus infection. S. aureus infected murine kidneys were fixed in paraformaldehyde, impregnated with gadolinium, and embedded in agar blocks, which were subjecte...

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Veröffentlicht in:	PloS one 2016-05, Vol.11 (5), p.e0154705-e0154705
Hauptverfasser:	Allen, Elizabeth R, van Diemen, Pauline, Yamaguchi, Yuko, Lindemann, Claudia, Soilleux, Elizabeth, Rollier, Christine, Hill, Fergal, Schneider, Jurgen, Wyllie, David H
Format:	Artikel
Sprache:	eng
Schlagworte:	Abscess Abscess - diagnostic imaging Abscess - immunology Abscess - microbiology Abscesses Administration, Intravenous Animals Antibiotics Bacteria Bacterial infections Binding sites Biology and Life Sciences Complications and side effects Computer simulation Endocarditis Enumeration Female Gadolinium Histology Image analysis Image processing Infections Intravenous administration Kidney - diagnostic imaging Kidney - immunology Kidney - microbiology Kidney Diseases - diagnostic imaging Kidney Diseases - immunology Kidney Diseases - microbiology Kidneys Laboratories Magnetic resonance Magnetic Resonance Imaging Medical research Medicine and Health Sciences Mice Mice, Inbred BALB C Microscopy NMR Nuclear magnetic resonance Organs Pathogens Physiology Proteins Research and Analysis Methods Risk factors Sortase Staphylococcal Infections - diagnosis Staphylococcal Infections - immunology Staphylococcal Vaccines - immunology Staphylococcal Vaccines - pharmacokinetics Staphylococcus aureus Staphylococcus aureus - immunology Staphylococcus aureus infections Staphylococcus infections Vaccination Vaccines
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