Effect of the IL-1 Receptor Antagonist Kineret® on Disease Phenotype in mdx Mice

Duchenne muscular dystrophy (DMD) is an X-linked muscle disease caused by mutations in the dystrophin gene. The pathology of DMD manifests in patients with progressive muscle weakness, loss of ambulation and ultimately death. One of the characteristics of DMD is muscle inflammation, and dystrophin-d...

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Veröffentlicht in:	PloS one 2016-05, Vol.11 (5), p.e0155944
Hauptverfasser:	Benny Klimek, Margaret E, Sali, Arpana, Rayavarapu, Sree, Van der Meulen, Jack H, Nagaraju, Kanneboyina
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animals Anxiety Arthritis Biology and Life Sciences Blocking Coordination Correlation analysis Cytokines Diabetes Disease Disease control Disease Models, Animal Dose-Response Relationship, Drug Duchenne's muscular dystrophy Dystrophin Dystrophy Female Forelimb - drug effects Forelimb - physiopathology Gene expression Grip strength Humans Inflammation Inhibitors Injections, Subcutaneous Interleukin 1 Interleukin 1 receptor antagonist Interleukin 1 Receptor Antagonist Protein - administration & dosage Interleukin 1 Receptor Antagonist Protein - pharmacology Interleukin-1beta - metabolism Laboratory animals Lipopolysaccharides Locomotion - drug effects Mathematical models Medical treatment Medicine Medicine and Health Sciences Mice Mice, Inbred mdx Motor Activity - drug effects Muscles Muscular dystrophy Muscular Dystrophy, Duchenne - drug therapy Muscular Dystrophy, Duchenne - immunology Muscular Dystrophy, Duchenne - physiopathology Mutation Parameters Pathology Phenotypes Proteins Research and Analysis Methods Rheumatoid arthritis Signal transduction Signal Transduction - drug effects Signaling Skeletal muscle Splenocytes Stimulation Toll-like receptors Tumor necrosis factor-TNF
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