Analysis of Paired Primary-Metastatic Hormone-Receptor Positive Breast Tumors (HRPBC) Uncovers Potential Novel Drivers of Hormonal Resistance

We sought to identify genetic variants associated with disease relapse and failure to hormonal treatment in hormone-receptor positive breast cancer (HRPBC). We analyzed a series of HRPBC with distant relapse, by sequencing pairs (n = 11) of tumors (primary and metastases) at >800X. Comparative ge...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2016-05, Vol.11 (5), p.e0155840-e0155840
Hauptverfasser:	Manso, Luis, Mourón, Silvana, Tress, Michael, Gómez-López, Gonzalo, Morente, Manuel, Ciruelos, Eva, Rubio-Camarillo, Miriam, Rodriguez-Peralto, Jose Luis, Pujana, Miguel A, Pisano, David G, Quintela-Fandino, Miguel
Format:	Artikel
Sprache:	eng
Schlagworte:	Alterations Analysis Antineoplastic Agents, Hormonal - therapeutic use Aromatase Aromatase Inhibitors - pharmacology Bioinformatics Biology and Life Sciences Biomedical research Breast - pathology Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer metastasis Cell cycle Cloning Comparative Genomic Hybridization Deoxyribonucleic acid Deprivation Development and progression DNA DNA methylation Drug Resistance, Neoplasm - genetics Failure analysis Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Genes Genetic aspects Genetic diversity Genetic variance Genetic Variation Hormones Hormones - metabolism Humans Hybridization Medical research Medical treatment Medicine and Health Sciences Metastases Metastasis Mutation Myc protein Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Oligonucleotide Array Sequence Analysis Physiological aspects Prognosis Receptors, Estrogen - metabolism Recurrence Research and Analysis Methods Retrospective Studies Review boards Risk Sequence Analysis, DNA Sequences Studies Tamoxifen - pharmacology Treatment Outcome Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!