The Challenges of Implementing Next Generation Sequencing Across a Large Healthcare System, and the Molecular Epidemiology and Antibiotic Susceptibilities of Carbapenemase-Producing Bacteria in the Healthcare System of the U.S. Department of Defense

We sought to: 1) provide an overview of the genomic epidemiology of an extensive collection of carbapenemase-producing bacteria (CPB) collected in the U.S. Department of Defense health system; 2) increase awareness of the public availability of the sequences, isolates, and customized antimicrobial r...

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Veröffentlicht in:	PloS one 2016-05, Vol.11 (5), p.e0155770-e0155770
Hauptverfasser:	Lesho, Emil, Clifford, Robert, Onmus-Leone, Fatma, Appalla, Lakshmi, Snesrud, Erik, Kwak, Yoon, Ong, Ana, Maybank, Rosslyn, Waterman, Paige, Rohrbeck, Patricia, Julius, Michael, Roth, Amanda, Martinez, Joshua, Nielsen, Lindsey, Steele, Eric, McGann, Patrick, Hinkle, Mary
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinetobacter - genetics Aminoglycosides Anti-Bacterial Agents - therapeutic use Antibiotics Antimicrobial agents Antimicrobial resistance Armed forces Bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism beta-Lactamases - metabolism Bioinformatics Biology and Life Sciences Carbapenemase Carbapenems - therapeutic use Clustering Computer Security Computer Systems Data base management systems Databases, Genetic Disease transmission DNA sequencing Drug resistance Drug Resistance, Bacterial - genetics Epidemics Epidemiology Federal agencies Fluoroquinolones Gene sequencing Genetic aspects Genome, Bacterial Genomes Genomics Genotype Genotypes Health care High-Throughput Nucleotide Sequencing - methods Hospitals Hospitals, Military Humans Infectious diseases Klebsiella - genetics Laboratories Medical Informatics - methods Medicine and Health Sciences Microbial drug resistance Microbial Sensitivity Tests Molecular Epidemiology - methods Multidrug resistance Multidrug resistant organisms Occupational exposure Outbreaks Pathogens Phenotype Plasmids Plasmids - metabolism Polymorphism, Single Nucleotide Public health Quality control Research and Analysis Methods Response time Single-nucleotide polymorphism Source code United States United States Department of Defense
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