ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production

ATP-binding cassette G1 (ABCG1) and ABCG4, expressed in neurons and glia in the central nervous system, mediate cholesterol efflux to lipid acceptors. The relationship between cholesterol level in the central nervous system and Alzheimer's disease has been reported. In this study, we examined t...

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Veröffentlicht in:	PloS one 2016-05, Vol.11 (5), p.e0155400-e0155400
Hauptverfasser:	Sano, Osamu, Tsujita, Maki, Shimizu, Yuji, Kato, Reiko, Kobayashi, Aya, Kioka, Noriyuki, Remaley, Alan T, Michikawa, Makoto, Ueda, Kazumitsu, Matsuo, Michinori
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Peptides - biosynthesis Amyloid precursor protein Amyloid Precursor Protein Secretases - genetics Amyloid Precursor Protein Secretases - metabolism Animals Apolipoproteins ATP Binding Cassette Transporter, Sub-Family G - genetics ATP Binding Cassette Transporter, Sub-Family G - metabolism ATP Binding Cassette Transporter, Sub-Family G, Member 1 - genetics ATP Binding Cassette Transporter, Sub-Family G, Member 1 - metabolism Biochemistry Biology and Life Sciences Caveolin 1 - metabolism Cell Line, Tumor Cell Membrane - metabolism Cell surface Central nervous system Cerebrospinal fluid Cholesterol Efflux Gene Silencing HEK293 Cells Humans Laboratories Life sciences Lipids Lipoproteins Localization Lysine Medical treatment Medicine and Health Sciences Membrane Glycoproteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout Mutation Neuronal-glial interactions Pathogenesis Proteins Research and Analysis Methods RNA Interference Rodents Secretase Secretion Statins University graduates
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