Wnt Signaling Alteration in the Spinal Cord of Amyotrophic Lateral Sclerosis Transgenic Mice: Special Focus on Frizzled-5 Cellular Expression Pattern

Amyotrophic lateral sclerosis is a chronic neurodegenerative disease characterized by progressive paralysis due to degeneration of motor neurons by unknown causes. Recent evidence shows that Wnt signaling is involved in neurodegenerative processes, including Amyotrophic Lateral Sclerosis. However, t...

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Veröffentlicht in:	PloS one 2016-05, Vol.11 (5), p.e0155867-e0155867
Hauptverfasser:	González-Fernández, Carlos, Mancuso, Renzo, Del Valle, Jaume, Navarro, Xavier, Rodríguez, Francisco Javier
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - metabolism Analysis Animals Biology and Life Sciences Cellular signal transduction Degeneration Development and progression Frizzled protein Frizzled Receptors - genetics Frizzled Receptors - metabolism Gene expression Gene regulation Genetic aspects Immunofluorescence Kinases Medicine and Health Sciences Mice Motor neurons Mutation Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurodegeneration Neurons Neurons - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Paralysis Physiological aspects Proteins Research and Analysis Methods RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Signaling Spinal cord Spinal Cord - cytology Spinal Cord - metabolism Superoxide Dismutase-1 - genetics Transcription Transgenic mice Wnt protein Wnt Signaling Pathway
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