Genomic Landscape Survey Identifies SRSF1 as a Key Oncodriver in Small Cell Lung Cancer
Small cell lung cancer (SCLC) is an aggressive disease with poor survival. A few sequencing studies performed on limited number of samples have revealed potential disease-driving genes in SCLC, however, much still remains unknown, particularly in the Asian patient population. Here we conducted whole...
Gespeichert in:
| Veröffentlicht in: | PLoS genetics 2016-04, Vol.12 (4), p.e1005895-e1005895 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e1005895 |
|---|---|
| container_issue | 4 |
| container_start_page | e1005895 |
| container_title | PLoS genetics |
| container_volume | 12 |
| creator | Jiang, Liyan Huang, Jiaqi Higgs, Brandon W Hu, Zhibin Xiao, Zhan Yao, Xin Conley, Sarah Zhong, Haihong Liu, Zheng Brohawn, Philip Shen, Dong Wu, Song Ge, Xiaoxiao Jiang, Yue Zhao, Yizhuo Lou, Yuqing Morehouse, Chris Zhu, Wei Sebastian, Yinong Czapiga, Meggan Oganesyan, Vaheh Fu, Haihua Niu, Yanjie Zhang, Wei Streicher, Katie Tice, David Zhao, Heng Zhu, Meng Xu, Lin Herbst, Ronald Su, Xinying Gu, Yi Li, Shyoung Huang, Lihua Gu, Jianren Han, Baohui Jallal, Bahija Shen, Hongbing Yao, Yihong |
| description | Small cell lung cancer (SCLC) is an aggressive disease with poor survival. A few sequencing studies performed on limited number of samples have revealed potential disease-driving genes in SCLC, however, much still remains unknown, particularly in the Asian patient population. Here we conducted whole exome sequencing (WES) and transcriptomic sequencing of primary tumors from 99 Chinese SCLC patients. Dysregulation of tumor suppressor genes TP53 and RB1 was observed in 82% and 62% of SCLC patients, respectively, and more than half of the SCLC patients (62%) harbored TP53 and RB1 mutation and/or copy number loss. Additionally, Serine/Arginine Splicing Factor 1 (SRSF1) DNA copy number gain and mRNA over-expression was strongly associated with poor survival using both discovery and validation patient cohorts. Functional studies in vitro and in vivo demonstrate that SRSF1 is important for tumorigenicity of SCLC and may play a key role in DNA repair and chemo-sensitivity. These results strongly support SRSF1 as a prognostic biomarker in SCLC and provide a rationale for personalized therapy in SCLC. |
| doi_str_mv | 10.1371/journal.pgen.1005895 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1789552364</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A479543190</galeid><doaj_id>oai_doaj_org_article_5a94d0c0e61d478c84e2d5a2d8db5b34</doaj_id><sourcerecordid>A479543190</sourcerecordid><originalsourceid>FETCH-LOGICAL-c759t-3473f8ea981d3d56a8b6624fcce6eff589eb7fe38e883594d6815c8c377571aa3</originalsourceid><addsrcrecordid>eNqVk12PEyEUhidG467Vf2B0EhOjF63DAANzY7Jp3LWxscnWj0tC4cyUZgoVZhr330vt7KZj9mINCRB4zsvhhZMkL1E2QZihDxvXeSubya4GO0FZRnlJHyXniFI8ZiQjj0_mZ8mzEDZZhiPEniZnOctKjHhxnvy8Auu2RqVzaXVQcgfpsvN7uElnGmxrKgMhXV4vL1EqQyrTL3FnYZXT3uzBp8amy61smnQKsZt3tk6n0irwz5MnlWwCvOjHUfL98tO36efxfHE1m17Mx4rRsh1jwnDFQZYcaaxpIfmqKHJSKQUFVFVMF1asAsyBc0xLoguOqOIKM0YZkhKPktdH3V3jgug9CQKx6AbNcUEiMTsS2smN2Hmzlf5GOGnE3wXnayF9a1QDgsp4QqYyKJAmjCtOINdU5prrFV3hg9bH_rRutQWtokNeNgPR4Y41a1G7vSAcF0WZR4F3vYB3vzoIrdiaoKJ30oLrDnmXhJSU5egBKMeYIBaHUfLmH_R-I3qqlvGuxlYupqgOouKCsJISjMosUpN7qNg0xG_iLFQmrg8C3g8CItPC77aWXQhitrz-D_brw9nFjyH79oRdg2zadXBN1xpnwxAkR1B5F4KH6u7tUCYOZXXrnDiUlejLKoa9On33u6DbOsJ_AMmgGbQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1789552364</pqid></control><display><type>article</type><title>Genomic Landscape Survey Identifies SRSF1 as a Key Oncodriver in Small Cell Lung Cancer</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Public Library of Science (PLoS)</source><creator>Jiang, Liyan ; Huang, Jiaqi ; Higgs, Brandon W ; Hu, Zhibin ; Xiao, Zhan ; Yao, Xin ; Conley, Sarah ; Zhong, Haihong ; Liu, Zheng ; Brohawn, Philip ; Shen, Dong ; Wu, Song ; Ge, Xiaoxiao ; Jiang, Yue ; Zhao, Yizhuo ; Lou, Yuqing ; Morehouse, Chris ; Zhu, Wei ; Sebastian, Yinong ; Czapiga, Meggan ; Oganesyan, Vaheh ; Fu, Haihua ; Niu, Yanjie ; Zhang, Wei ; Streicher, Katie ; Tice, David ; Zhao, Heng ; Zhu, Meng ; Xu, Lin ; Herbst, Ronald ; Su, Xinying ; Gu, Yi ; Li, Shyoung ; Huang, Lihua ; Gu, Jianren ; Han, Baohui ; Jallal, Bahija ; Shen, Hongbing ; Yao, Yihong</creator><creatorcontrib>Jiang, Liyan ; Huang, Jiaqi ; Higgs, Brandon W ; Hu, Zhibin ; Xiao, Zhan ; Yao, Xin ; Conley, Sarah ; Zhong, Haihong ; Liu, Zheng ; Brohawn, Philip ; Shen, Dong ; Wu, Song ; Ge, Xiaoxiao ; Jiang, Yue ; Zhao, Yizhuo ; Lou, Yuqing ; Morehouse, Chris ; Zhu, Wei ; Sebastian, Yinong ; Czapiga, Meggan ; Oganesyan, Vaheh ; Fu, Haihua ; Niu, Yanjie ; Zhang, Wei ; Streicher, Katie ; Tice, David ; Zhao, Heng ; Zhu, Meng ; Xu, Lin ; Herbst, Ronald ; Su, Xinying ; Gu, Yi ; Li, Shyoung ; Huang, Lihua ; Gu, Jianren ; Han, Baohui ; Jallal, Bahija ; Shen, Hongbing ; Yao, Yihong</creatorcontrib><description>Small cell lung cancer (SCLC) is an aggressive disease with poor survival. A few sequencing studies performed on limited number of samples have revealed potential disease-driving genes in SCLC, however, much still remains unknown, particularly in the Asian patient population. Here we conducted whole exome sequencing (WES) and transcriptomic sequencing of primary tumors from 99 Chinese SCLC patients. Dysregulation of tumor suppressor genes TP53 and RB1 was observed in 82% and 62% of SCLC patients, respectively, and more than half of the SCLC patients (62%) harbored TP53 and RB1 mutation and/or copy number loss. Additionally, Serine/Arginine Splicing Factor 1 (SRSF1) DNA copy number gain and mRNA over-expression was strongly associated with poor survival using both discovery and validation patient cohorts. Functional studies in vitro and in vivo demonstrate that SRSF1 is important for tumorigenicity of SCLC and may play a key role in DNA repair and chemo-sensitivity. These results strongly support SRSF1 as a prognostic biomarker in SCLC and provide a rationale for personalized therapy in SCLC.</description><identifier>ISSN: 1553-7404</identifier><identifier>ISSN: 1553-7390</identifier><identifier>EISSN: 1553-7404</identifier><identifier>DOI: 10.1371/journal.pgen.1005895</identifier><identifier>PMID: 27093186</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Biology and life sciences ; Cancer therapies ; Carcinoma, Small Cell - genetics ; Deoxyribonucleic acid ; Disease ; DNA ; DNA Copy Number Variations ; DNA Damage ; DNA repair ; DNA sequencing ; Female ; Gene expression ; Gene Silencing ; Genetic aspects ; Genomics ; Health aspects ; Humans ; Lung cancer ; Lung Neoplasms - genetics ; Male ; Medicine and Health Sciences ; Methods ; Middle Aged ; Mutation ; Oncogene Proteins - genetics ; People and Places ; Serine-Arginine Splicing Factors - genetics ; Small cell lung cancer ; Studies ; Tumors</subject><ispartof>PLoS genetics, 2016-04, Vol.12 (4), p.e1005895-e1005895</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: as a Key Oncodriver in Small Cell Lung Cancer. PLoS Genet 12(4): e1005895. doi:10.1371/journal.pgen.1005895</rights><rights>2016 Jiang et al 2016 Jiang et al</rights><rights>2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: as a Key Oncodriver in Small Cell Lung Cancer. PLoS Genet 12(4): e1005895. doi:10.1371/journal.pgen.1005895</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c759t-3473f8ea981d3d56a8b6624fcce6eff589eb7fe38e883594d6815c8c377571aa3</citedby><cites>FETCH-LOGICAL-c759t-3473f8ea981d3d56a8b6624fcce6eff589eb7fe38e883594d6815c8c377571aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836692/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836692/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27093186$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Liyan</creatorcontrib><creatorcontrib>Huang, Jiaqi</creatorcontrib><creatorcontrib>Higgs, Brandon W</creatorcontrib><creatorcontrib>Hu, Zhibin</creatorcontrib><creatorcontrib>Xiao, Zhan</creatorcontrib><creatorcontrib>Yao, Xin</creatorcontrib><creatorcontrib>Conley, Sarah</creatorcontrib><creatorcontrib>Zhong, Haihong</creatorcontrib><creatorcontrib>Liu, Zheng</creatorcontrib><creatorcontrib>Brohawn, Philip</creatorcontrib><creatorcontrib>Shen, Dong</creatorcontrib><creatorcontrib>Wu, Song</creatorcontrib><creatorcontrib>Ge, Xiaoxiao</creatorcontrib><creatorcontrib>Jiang, Yue</creatorcontrib><creatorcontrib>Zhao, Yizhuo</creatorcontrib><creatorcontrib>Lou, Yuqing</creatorcontrib><creatorcontrib>Morehouse, Chris</creatorcontrib><creatorcontrib>Zhu, Wei</creatorcontrib><creatorcontrib>Sebastian, Yinong</creatorcontrib><creatorcontrib>Czapiga, Meggan</creatorcontrib><creatorcontrib>Oganesyan, Vaheh</creatorcontrib><creatorcontrib>Fu, Haihua</creatorcontrib><creatorcontrib>Niu, Yanjie</creatorcontrib><creatorcontrib>Zhang, Wei</creatorcontrib><creatorcontrib>Streicher, Katie</creatorcontrib><creatorcontrib>Tice, David</creatorcontrib><creatorcontrib>Zhao, Heng</creatorcontrib><creatorcontrib>Zhu, Meng</creatorcontrib><creatorcontrib>Xu, Lin</creatorcontrib><creatorcontrib>Herbst, Ronald</creatorcontrib><creatorcontrib>Su, Xinying</creatorcontrib><creatorcontrib>Gu, Yi</creatorcontrib><creatorcontrib>Li, Shyoung</creatorcontrib><creatorcontrib>Huang, Lihua</creatorcontrib><creatorcontrib>Gu, Jianren</creatorcontrib><creatorcontrib>Han, Baohui</creatorcontrib><creatorcontrib>Jallal, Bahija</creatorcontrib><creatorcontrib>Shen, Hongbing</creatorcontrib><creatorcontrib>Yao, Yihong</creatorcontrib><title>Genomic Landscape Survey Identifies SRSF1 as a Key Oncodriver in Small Cell Lung Cancer</title><title>PLoS genetics</title><addtitle>PLoS Genet</addtitle><description>Small cell lung cancer (SCLC) is an aggressive disease with poor survival. A few sequencing studies performed on limited number of samples have revealed potential disease-driving genes in SCLC, however, much still remains unknown, particularly in the Asian patient population. Here we conducted whole exome sequencing (WES) and transcriptomic sequencing of primary tumors from 99 Chinese SCLC patients. Dysregulation of tumor suppressor genes TP53 and RB1 was observed in 82% and 62% of SCLC patients, respectively, and more than half of the SCLC patients (62%) harbored TP53 and RB1 mutation and/or copy number loss. Additionally, Serine/Arginine Splicing Factor 1 (SRSF1) DNA copy number gain and mRNA over-expression was strongly associated with poor survival using both discovery and validation patient cohorts. Functional studies in vitro and in vivo demonstrate that SRSF1 is important for tumorigenicity of SCLC and may play a key role in DNA repair and chemo-sensitivity. These results strongly support SRSF1 as a prognostic biomarker in SCLC and provide a rationale for personalized therapy in SCLC.</description><subject>Adult</subject><subject>Aged</subject><subject>Biology and life sciences</subject><subject>Cancer therapies</subject><subject>Carcinoma, Small Cell - genetics</subject><subject>Deoxyribonucleic acid</subject><subject>Disease</subject><subject>DNA</subject><subject>DNA Copy Number Variations</subject><subject>DNA Damage</subject><subject>DNA repair</subject><subject>DNA sequencing</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Silencing</subject><subject>Genetic aspects</subject><subject>Genomics</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - genetics</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Oncogene Proteins - genetics</subject><subject>People and Places</subject><subject>Serine-Arginine Splicing Factors - genetics</subject><subject>Small cell lung cancer</subject><subject>Studies</subject><subject>Tumors</subject><issn>1553-7404</issn><issn>1553-7390</issn><issn>1553-7404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqVk12PEyEUhidG467Vf2B0EhOjF63DAANzY7Jp3LWxscnWj0tC4cyUZgoVZhr330vt7KZj9mINCRB4zsvhhZMkL1E2QZihDxvXeSubya4GO0FZRnlJHyXniFI8ZiQjj0_mZ8mzEDZZhiPEniZnOctKjHhxnvy8Auu2RqVzaXVQcgfpsvN7uElnGmxrKgMhXV4vL1EqQyrTL3FnYZXT3uzBp8amy61smnQKsZt3tk6n0irwz5MnlWwCvOjHUfL98tO36efxfHE1m17Mx4rRsh1jwnDFQZYcaaxpIfmqKHJSKQUFVFVMF1asAsyBc0xLoguOqOIKM0YZkhKPktdH3V3jgug9CQKx6AbNcUEiMTsS2smN2Hmzlf5GOGnE3wXnayF9a1QDgsp4QqYyKJAmjCtOINdU5prrFV3hg9bH_rRutQWtokNeNgPR4Y41a1G7vSAcF0WZR4F3vYB3vzoIrdiaoKJ30oLrDnmXhJSU5egBKMeYIBaHUfLmH_R-I3qqlvGuxlYupqgOouKCsJISjMosUpN7qNg0xG_iLFQmrg8C3g8CItPC77aWXQhitrz-D_brw9nFjyH79oRdg2zadXBN1xpnwxAkR1B5F4KH6u7tUCYOZXXrnDiUlejLKoa9On33u6DbOsJ_AMmgGbQ</recordid><startdate>20160419</startdate><enddate>20160419</enddate><creator>Jiang, Liyan</creator><creator>Huang, Jiaqi</creator><creator>Higgs, Brandon W</creator><creator>Hu, Zhibin</creator><creator>Xiao, Zhan</creator><creator>Yao, Xin</creator><creator>Conley, Sarah</creator><creator>Zhong, Haihong</creator><creator>Liu, Zheng</creator><creator>Brohawn, Philip</creator><creator>Shen, Dong</creator><creator>Wu, Song</creator><creator>Ge, Xiaoxiao</creator><creator>Jiang, Yue</creator><creator>Zhao, Yizhuo</creator><creator>Lou, Yuqing</creator><creator>Morehouse, Chris</creator><creator>Zhu, Wei</creator><creator>Sebastian, Yinong</creator><creator>Czapiga, Meggan</creator><creator>Oganesyan, Vaheh</creator><creator>Fu, Haihua</creator><creator>Niu, Yanjie</creator><creator>Zhang, Wei</creator><creator>Streicher, Katie</creator><creator>Tice, David</creator><creator>Zhao, Heng</creator><creator>Zhu, Meng</creator><creator>Xu, Lin</creator><creator>Herbst, Ronald</creator><creator>Su, Xinying</creator><creator>Gu, Yi</creator><creator>Li, Shyoung</creator><creator>Huang, Lihua</creator><creator>Gu, Jianren</creator><creator>Han, Baohui</creator><creator>Jallal, Bahija</creator><creator>Shen, Hongbing</creator><creator>Yao, Yihong</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISN</scope><scope>ISR</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20160419</creationdate><title>Genomic Landscape Survey Identifies SRSF1 as a Key Oncodriver in Small Cell Lung Cancer</title><author>Jiang, Liyan ; Huang, Jiaqi ; Higgs, Brandon W ; Hu, Zhibin ; Xiao, Zhan ; Yao, Xin ; Conley, Sarah ; Zhong, Haihong ; Liu, Zheng ; Brohawn, Philip ; Shen, Dong ; Wu, Song ; Ge, Xiaoxiao ; Jiang, Yue ; Zhao, Yizhuo ; Lou, Yuqing ; Morehouse, Chris ; Zhu, Wei ; Sebastian, Yinong ; Czapiga, Meggan ; Oganesyan, Vaheh ; Fu, Haihua ; Niu, Yanjie ; Zhang, Wei ; Streicher, Katie ; Tice, David ; Zhao, Heng ; Zhu, Meng ; Xu, Lin ; Herbst, Ronald ; Su, Xinying ; Gu, Yi ; Li, Shyoung ; Huang, Lihua ; Gu, Jianren ; Han, Baohui ; Jallal, Bahija ; Shen, Hongbing ; Yao, Yihong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c759t-3473f8ea981d3d56a8b6624fcce6eff589eb7fe38e883594d6815c8c377571aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biology and life sciences</topic><topic>Cancer therapies</topic><topic>Carcinoma, Small Cell - genetics</topic><topic>Deoxyribonucleic acid</topic><topic>Disease</topic><topic>DNA</topic><topic>DNA Copy Number Variations</topic><topic>DNA Damage</topic><topic>DNA repair</topic><topic>DNA sequencing</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Silencing</topic><topic>Genetic aspects</topic><topic>Genomics</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - genetics</topic><topic>Male</topic><topic>Medicine and Health Sciences</topic><topic>Methods</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Oncogene Proteins - genetics</topic><topic>People and Places</topic><topic>Serine-Arginine Splicing Factors - genetics</topic><topic>Small cell lung cancer</topic><topic>Studies</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Liyan</creatorcontrib><creatorcontrib>Huang, Jiaqi</creatorcontrib><creatorcontrib>Higgs, Brandon W</creatorcontrib><creatorcontrib>Hu, Zhibin</creatorcontrib><creatorcontrib>Xiao, Zhan</creatorcontrib><creatorcontrib>Yao, Xin</creatorcontrib><creatorcontrib>Conley, Sarah</creatorcontrib><creatorcontrib>Zhong, Haihong</creatorcontrib><creatorcontrib>Liu, Zheng</creatorcontrib><creatorcontrib>Brohawn, Philip</creatorcontrib><creatorcontrib>Shen, Dong</creatorcontrib><creatorcontrib>Wu, Song</creatorcontrib><creatorcontrib>Ge, Xiaoxiao</creatorcontrib><creatorcontrib>Jiang, Yue</creatorcontrib><creatorcontrib>Zhao, Yizhuo</creatorcontrib><creatorcontrib>Lou, Yuqing</creatorcontrib><creatorcontrib>Morehouse, Chris</creatorcontrib><creatorcontrib>Zhu, Wei</creatorcontrib><creatorcontrib>Sebastian, Yinong</creatorcontrib><creatorcontrib>Czapiga, Meggan</creatorcontrib><creatorcontrib>Oganesyan, Vaheh</creatorcontrib><creatorcontrib>Fu, Haihua</creatorcontrib><creatorcontrib>Niu, Yanjie</creatorcontrib><creatorcontrib>Zhang, Wei</creatorcontrib><creatorcontrib>Streicher, Katie</creatorcontrib><creatorcontrib>Tice, David</creatorcontrib><creatorcontrib>Zhao, Heng</creatorcontrib><creatorcontrib>Zhu, Meng</creatorcontrib><creatorcontrib>Xu, Lin</creatorcontrib><creatorcontrib>Herbst, Ronald</creatorcontrib><creatorcontrib>Su, Xinying</creatorcontrib><creatorcontrib>Gu, Yi</creatorcontrib><creatorcontrib>Li, Shyoung</creatorcontrib><creatorcontrib>Huang, Lihua</creatorcontrib><creatorcontrib>Gu, Jianren</creatorcontrib><creatorcontrib>Han, Baohui</creatorcontrib><creatorcontrib>Jallal, Bahija</creatorcontrib><creatorcontrib>Shen, Hongbing</creatorcontrib><creatorcontrib>Yao, Yihong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Liyan</au><au>Huang, Jiaqi</au><au>Higgs, Brandon W</au><au>Hu, Zhibin</au><au>Xiao, Zhan</au><au>Yao, Xin</au><au>Conley, Sarah</au><au>Zhong, Haihong</au><au>Liu, Zheng</au><au>Brohawn, Philip</au><au>Shen, Dong</au><au>Wu, Song</au><au>Ge, Xiaoxiao</au><au>Jiang, Yue</au><au>Zhao, Yizhuo</au><au>Lou, Yuqing</au><au>Morehouse, Chris</au><au>Zhu, Wei</au><au>Sebastian, Yinong</au><au>Czapiga, Meggan</au><au>Oganesyan, Vaheh</au><au>Fu, Haihua</au><au>Niu, Yanjie</au><au>Zhang, Wei</au><au>Streicher, Katie</au><au>Tice, David</au><au>Zhao, Heng</au><au>Zhu, Meng</au><au>Xu, Lin</au><au>Herbst, Ronald</au><au>Su, Xinying</au><au>Gu, Yi</au><au>Li, Shyoung</au><au>Huang, Lihua</au><au>Gu, Jianren</au><au>Han, Baohui</au><au>Jallal, Bahija</au><au>Shen, Hongbing</au><au>Yao, Yihong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genomic Landscape Survey Identifies SRSF1 as a Key Oncodriver in Small Cell Lung Cancer</atitle><jtitle>PLoS genetics</jtitle><addtitle>PLoS Genet</addtitle><date>2016-04-19</date><risdate>2016</risdate><volume>12</volume><issue>4</issue><spage>e1005895</spage><epage>e1005895</epage><pages>e1005895-e1005895</pages><issn>1553-7404</issn><issn>1553-7390</issn><eissn>1553-7404</eissn><abstract>Small cell lung cancer (SCLC) is an aggressive disease with poor survival. A few sequencing studies performed on limited number of samples have revealed potential disease-driving genes in SCLC, however, much still remains unknown, particularly in the Asian patient population. Here we conducted whole exome sequencing (WES) and transcriptomic sequencing of primary tumors from 99 Chinese SCLC patients. Dysregulation of tumor suppressor genes TP53 and RB1 was observed in 82% and 62% of SCLC patients, respectively, and more than half of the SCLC patients (62%) harbored TP53 and RB1 mutation and/or copy number loss. Additionally, Serine/Arginine Splicing Factor 1 (SRSF1) DNA copy number gain and mRNA over-expression was strongly associated with poor survival using both discovery and validation patient cohorts. Functional studies in vitro and in vivo demonstrate that SRSF1 is important for tumorigenicity of SCLC and may play a key role in DNA repair and chemo-sensitivity. These results strongly support SRSF1 as a prognostic biomarker in SCLC and provide a rationale for personalized therapy in SCLC.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27093186</pmid><doi>10.1371/journal.pgen.1005895</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1553-7404 |
| ispartof | PLoS genetics, 2016-04, Vol.12 (4), p.e1005895-e1005895 |
| issn | 1553-7404 1553-7390 1553-7404 |
| language | eng |
| recordid | cdi_plos_journals_1789552364 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Public Library of Science (PLoS) |
| subjects | Adult Aged Biology and life sciences Cancer therapies Carcinoma, Small Cell - genetics Deoxyribonucleic acid Disease DNA DNA Copy Number Variations DNA Damage DNA repair DNA sequencing Female Gene expression Gene Silencing Genetic aspects Genomics Health aspects Humans Lung cancer Lung Neoplasms - genetics Male Medicine and Health Sciences Methods Middle Aged Mutation Oncogene Proteins - genetics People and Places Serine-Arginine Splicing Factors - genetics Small cell lung cancer Studies Tumors |
| title | Genomic Landscape Survey Identifies SRSF1 as a Key Oncodriver in Small Cell Lung Cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T15%3A22%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genomic%20Landscape%20Survey%20Identifies%20SRSF1%20as%20a%20Key%20Oncodriver%20in%20Small%20Cell%20Lung%20Cancer&rft.jtitle=PLoS%20genetics&rft.au=Jiang,%20Liyan&rft.date=2016-04-19&rft.volume=12&rft.issue=4&rft.spage=e1005895&rft.epage=e1005895&rft.pages=e1005895-e1005895&rft.issn=1553-7404&rft.eissn=1553-7404&rft_id=info:doi/10.1371/journal.pgen.1005895&rft_dat=%3Cgale_plos_%3EA479543190%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1789552364&rft_id=info:pmid/27093186&rft_galeid=A479543190&rft_doaj_id=oai_doaj_org_article_5a94d0c0e61d478c84e2d5a2d8db5b34&rfr_iscdi=true |