The Increasing Importance of Gene-Based Analyses

In recent years, genome and exome sequencing studies have implicated a plethora of new disease genes with rare causal variants. Here, I review 150 exome sequencing studies that claim to have discovered that a disease can be caused by different rare variants in the same gene, and I determine whether...

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Veröffentlicht in:	PLoS genetics 2016-04, Vol.12 (4), p.e1005852-e1005852
1. Verfasser:	Cirulli, Elizabeth T
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and Life Sciences Exome Gene expression Genes Genetic research Genetic Testing Genetic variation High-Throughput Nucleotide Sequencing Humans Methods Mutation Physical Sciences Research and Analysis Methods Review Studies
Online-Zugang:	Volltext
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