shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity

Alpha-Synuclein (aSyn) misfolding and aggregation is common in several neurodegenerative diseases, including Parkinson's disease and dementia with Lewy bodies, which are known as synucleinopathies. Accumulating evidence suggests that secretion and cell-to-cell trafficking of pathological forms...

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Veröffentlicht in:	PLoS genetics 2016-04, Vol.12 (4), p.e1005995-e1005995
Hauptverfasser:	Gonçalves, Susana A, Macedo, Diana, Raquel, Helena, Simões, Pedro D, Giorgini, Flaviano, Ramalho, José S, Barral, Duarte C, Ferreira Moita, Luís, Outeiro, Tiago Fleming
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - genetics alpha-Synuclein - metabolism Biology and Life Sciences Calcium-Calmodulin-Dependent Protein Kinase Type 1 - genetics Carrier Proteins - genetics Cell Line Dementia DNA-Binding Proteins - genetics Dyrk Kinases Funding Genetic aspects Humans Kinases Lewy Body Disease - genetics Medicine and Health Sciences Membrane Proteins - genetics Methods Microscopy Neurodegeneration Oncogene Proteins - genetics Parkinson disease Parkinson Disease - genetics Parkinson's disease Parkinsons disease Pathology Physical Sciences Protein Aggregates - genetics Protein Folding Protein Serine-Threonine Kinases - genetics Protein Transport - genetics Protein-Tyrosine Kinases - genetics Proteins rab GTP-Binding Proteins - biosynthesis rab GTP-Binding Proteins - genetics Research and Analysis Methods RNA Interference RNA sequencing RNA, Small Interfering - genetics Signal transduction Toxicity
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