Allelic Imbalance in Regulation of ANRIL through Chromatin Interaction at 9p21 Endometriosis Risk Locus

Genome-wide association studies (GWASs) have discovered numerous single nucleotide polymorphisms (SNPs) associated with human complex disorders. However, functional characterization of the disease-associated SNPs remains a formidable challenge. Here we explored regulatory mechanism of a SNP on chrom...

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Veröffentlicht in:	PLoS genetics 2016-04, Vol.12 (4), p.e1005893-e1005893
Hauptverfasser:	Nakaoka, Hirofumi, Gurumurthy, Aishwarya, Hayano, Takahide, Ahmadloo, Somayeh, Omer, Waleed H, Yoshihara, Kosuke, Yamamoto, Akihito, Kurose, Keisuke, Enomoto, Takayuki, Akira, Shigeo, Hosomichi, Kazuyoshi, Inoue, Ituro
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Allelic Imbalance Archives & records Bioinformatics Biology and Life Sciences Cardiovascular disease Cell cycle Cell Line, Tumor Chromatin Chromatin - genetics Chromosomes Chromosomes, Human, Pair 9 E1A-Associated p300 Protein - metabolism Endometriosis Endometriosis - genetics Female Gene expression Genetic aspects Genome-wide association studies Genome-Wide Association Study Genomes Genomics Genotype & phenotype Haplotypes Health aspects Humans Medicine and Health Sciences Polymorphism, Single Nucleotide Promoter Regions, Genetic Research and Analysis Methods Risk factors RNA polymerase RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Single nucleotide polymorphisms Studies Transcription Factor 7-Like 2 Protein - metabolism Transcription factors
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