TGF-β Small Molecule Inhibitor SB431542 Reduces Rotator Cuff Muscle Fibrosis and Fatty Infiltration By Promoting Fibro/Adipogenic Progenitor Apoptosis

Rotator cuff tears represent a large burden of muscle-tendon injuries in our aging population. While small tears can be repaired surgically with good outcomes, critical size tears are marked by muscle atrophy, fibrosis, and fatty infiltration, which can lead to failed repair, frequent re-injury, and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2016-05, Vol.11 (5), p.e0155486-e0155486
Hauptverfasser:	Davies, Michael R, Liu, Xuhui, Lee, Lawrence, Laron, Dominique, Ning, Anne Y, Kim, Hubert T, Feeley, Brian T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - drug effects Adipose Tissue - pathology Aging Animals Apoptosis Apoptosis - drug effects Atrophy Benzamides - pharmacology Biology and life sciences Dioxoles - pharmacology Disease Models, Animal Drug development Female Fibrosis Gene expression Gene Expression Regulation - drug effects Growth factors Infiltration Inhibitors Injuries Kinases Medicine and Health Sciences Mice Muscles Muscular Atrophy - drug therapy Musculoskeletal system Phosphorylation Research and Analysis Methods Rotator Cuff - drug effects Rotator Cuff - metabolism Rotator Cuff - pathology Rotator Cuff Injuries - genetics Rotator Cuff Injuries - metabolism Rotator Cuff Injuries - pathology Signal transduction Signal Transduction - drug effects Signaling Stem Cells - cytology Stem Cells - drug effects Surgery Tearing Transforming growth factor Transforming Growth Factor beta - antagonists & inhibitors Transforming growth factor-b Transforming growth factor-b1 Veterans
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!