Early-Onset Thrombocytopenia in Small-For-Gestational-Age Neonates: A Retrospective Cohort Study
Thrombocytopenia is a common finding in small for gestational age (SGA) neonates and is thought to result from a unique pathophysiologic mechanism related to chronic intrauterine hypoxia. Our objective was to estimate the incidence and severity of early-onset thrombocytopenia in SGA neonates, and to...
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| description | Thrombocytopenia is a common finding in small for gestational age (SGA) neonates and is thought to result from a unique pathophysiologic mechanism related to chronic intrauterine hypoxia. Our objective was to estimate the incidence and severity of early-onset thrombocytopenia in SGA neonates, and to identify risk factors for thrombocytopenia. We performed a retrospective cohort study of all consecutive SGA neonates admitted to our ward and a control group of appropriate for gestational age (AGA) neonates matched for gestational age at birth. Main outcome measures were incidence and severity of thrombocytopenia, hematological and clinical risk factors for thrombocytopenia, and bleeding. A total of 330 SGA and 330 AGA neonates were included, with a mean gestational age at birth of 32.9 ± 4 weeks. Thrombocytopenia ( |
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Our objective was to estimate the incidence and severity of early-onset thrombocytopenia in SGA neonates, and to identify risk factors for thrombocytopenia. We performed a retrospective cohort study of all consecutive SGA neonates admitted to our ward and a control group of appropriate for gestational age (AGA) neonates matched for gestational age at birth. Main outcome measures were incidence and severity of thrombocytopenia, hematological and clinical risk factors for thrombocytopenia, and bleeding. A total of 330 SGA and 330 AGA neonates were included, with a mean gestational age at birth of 32.9 ± 4 weeks. Thrombocytopenia (<150x10(9)/L) was found in 53% (176/329) of SGA neonates and 20% (66/330) of AGA neonates (relative risk (RR) 2.7, 95% confidence interval (CI) [2.1, 3.4]). Severe thrombocytopenia (21-50x10(9)/L) occurred in 25 neonates (8%) in the SGA and 2 neonates (1%) in the AGA group (RR 12.5, 95% CI [3.0, 52.5]). Platelet counts <20x10(9)/L were not recorded. Within the SGA group, lower gestational age at birth (p = <0.01) and erythroblastosis (p<0.01) were independently associated with a decrease in platelet count. Platelet count was positively correlated with birth weight centiles. In conclusion, early-onset thrombocytopenia is present in over 50% of SGA neonates and occurs 2.7 times as often as in AGA neonates. Thrombocytopenia is seldom severe and is independently associated with lower gestational age at birth and erythroblastosis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0154853</identifier><identifier>PMID: 27177157</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Age of Onset ; Analysis ; Biology and Life Sciences ; Birth Weight ; Bleeding ; Blood platelets ; Blood pressure ; Cohort analysis ; Confidence intervals ; Development and progression ; Diagnosis ; Erythrocytes - metabolism ; Female ; Fetuses ; Gestational age ; Health aspects ; Hematology ; Hemorrhage ; Hemorrhage - complications ; Humans ; Hypertension ; Hypoxia ; Incidence ; Infant, Newborn ; Infant, Small for Gestational Age - blood ; Internet ; Male ; Medicine and Health Sciences ; Mortality ; Neonates ; Newborn babies ; Newborn infants ; Pediatrics ; Platelet Count ; Platelets ; Retrospective Studies ; Risk analysis ; Risk Factors ; Sepsis ; Small for gestational age ; Studies ; Thrombocytopenia ; Thrombocytopenia - blood ; Thrombocytopenia - complications ; Thrombocytopenia - epidemiology</subject><ispartof>PloS one, 2016-05, Vol.11 (5), p.e0154853-e0154853</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Fustolo-Gunnink et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Fustolo-Gunnink et al 2016 Fustolo-Gunnink et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-3e8ff546f88b84166a8a807361f204469719b232e6ab2e7c2db8a70fdb7183ed3</citedby><cites>FETCH-LOGICAL-c758t-3e8ff546f88b84166a8a807361f204469719b232e6ab2e7c2db8a70fdb7183ed3</cites><orcidid>0000-0002-1607-2581</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866768/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866768/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27177157$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fustolo-Gunnink, S F</creatorcontrib><creatorcontrib>Vlug, R D</creatorcontrib><creatorcontrib>Smits-Wintjens, V E H J</creatorcontrib><creatorcontrib>Heckman, E J</creatorcontrib><creatorcontrib>Te Pas, A B</creatorcontrib><creatorcontrib>Fijnvandraat, K</creatorcontrib><creatorcontrib>Lopriore, E</creatorcontrib><title>Early-Onset Thrombocytopenia in Small-For-Gestational-Age Neonates: A Retrospective Cohort Study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Thrombocytopenia is a common finding in small for gestational age (SGA) neonates and is thought to result from a unique pathophysiologic mechanism related to chronic intrauterine hypoxia. Our objective was to estimate the incidence and severity of early-onset thrombocytopenia in SGA neonates, and to identify risk factors for thrombocytopenia. We performed a retrospective cohort study of all consecutive SGA neonates admitted to our ward and a control group of appropriate for gestational age (AGA) neonates matched for gestational age at birth. Main outcome measures were incidence and severity of thrombocytopenia, hematological and clinical risk factors for thrombocytopenia, and bleeding. A total of 330 SGA and 330 AGA neonates were included, with a mean gestational age at birth of 32.9 ± 4 weeks. Thrombocytopenia (<150x10(9)/L) was found in 53% (176/329) of SGA neonates and 20% (66/330) of AGA neonates (relative risk (RR) 2.7, 95% confidence interval (CI) [2.1, 3.4]). Severe thrombocytopenia (21-50x10(9)/L) occurred in 25 neonates (8%) in the SGA and 2 neonates (1%) in the AGA group (RR 12.5, 95% CI [3.0, 52.5]). Platelet counts <20x10(9)/L were not recorded. Within the SGA group, lower gestational age at birth (p = <0.01) and erythroblastosis (p<0.01) were independently associated with a decrease in platelet count. Platelet count was positively correlated with birth weight centiles. In conclusion, early-onset thrombocytopenia is present in over 50% of SGA neonates and occurs 2.7 times as often as in AGA neonates. Thrombocytopenia is seldom severe and is independently associated with lower gestational age at birth and erythroblastosis.</description><subject>Age</subject><subject>Age of Onset</subject><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Birth Weight</subject><subject>Bleeding</subject><subject>Blood platelets</subject><subject>Blood pressure</subject><subject>Cohort analysis</subject><subject>Confidence intervals</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Erythrocytes - metabolism</subject><subject>Female</subject><subject>Fetuses</subject><subject>Gestational age</subject><subject>Health aspects</subject><subject>Hematology</subject><subject>Hemorrhage</subject><subject>Hemorrhage - complications</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypoxia</subject><subject>Incidence</subject><subject>Infant, Newborn</subject><subject>Infant, Small for Gestational Age - blood</subject><subject>Internet</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Mortality</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Newborn infants</subject><subject>Pediatrics</subject><subject>Platelet Count</subject><subject>Platelets</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Sepsis</subject><subject>Small for gestational age</subject><subject>Studies</subject><subject>Thrombocytopenia</subject><subject>Thrombocytopenia - 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Our objective was to estimate the incidence and severity of early-onset thrombocytopenia in SGA neonates, and to identify risk factors for thrombocytopenia. We performed a retrospective cohort study of all consecutive SGA neonates admitted to our ward and a control group of appropriate for gestational age (AGA) neonates matched for gestational age at birth. Main outcome measures were incidence and severity of thrombocytopenia, hematological and clinical risk factors for thrombocytopenia, and bleeding. A total of 330 SGA and 330 AGA neonates were included, with a mean gestational age at birth of 32.9 ± 4 weeks. Thrombocytopenia (<150x10(9)/L) was found in 53% (176/329) of SGA neonates and 20% (66/330) of AGA neonates (relative risk (RR) 2.7, 95% confidence interval (CI) [2.1, 3.4]). Severe thrombocytopenia (21-50x10(9)/L) occurred in 25 neonates (8%) in the SGA and 2 neonates (1%) in the AGA group (RR 12.5, 95% CI [3.0, 52.5]). Platelet counts <20x10(9)/L were not recorded. Within the SGA group, lower gestational age at birth (p = <0.01) and erythroblastosis (p<0.01) were independently associated with a decrease in platelet count. Platelet count was positively correlated with birth weight centiles. In conclusion, early-onset thrombocytopenia is present in over 50% of SGA neonates and occurs 2.7 times as often as in AGA neonates. Thrombocytopenia is seldom severe and is independently associated with lower gestational age at birth and erythroblastosis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27177157</pmid><doi>10.1371/journal.pone.0154853</doi><orcidid>https://orcid.org/0000-0002-1607-2581</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2016-05, Vol.11 (5), p.e0154853-e0154853 |
| issn | 1932-6203 1932-6203 |
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| subjects | Age Age of Onset Analysis Biology and Life Sciences Birth Weight Bleeding Blood platelets Blood pressure Cohort analysis Confidence intervals Development and progression Diagnosis Erythrocytes - metabolism Female Fetuses Gestational age Health aspects Hematology Hemorrhage Hemorrhage - complications Humans Hypertension Hypoxia Incidence Infant, Newborn Infant, Small for Gestational Age - blood Internet Male Medicine and Health Sciences Mortality Neonates Newborn babies Newborn infants Pediatrics Platelet Count Platelets Retrospective Studies Risk analysis Risk Factors Sepsis Small for gestational age Studies Thrombocytopenia Thrombocytopenia - blood Thrombocytopenia - complications Thrombocytopenia - epidemiology |
| title | Early-Onset Thrombocytopenia in Small-For-Gestational-Age Neonates: A Retrospective Cohort Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T15%3A32%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Early-Onset%20Thrombocytopenia%20in%20Small-For-Gestational-Age%20Neonates:%20A%20Retrospective%20Cohort%20Study&rft.jtitle=PloS%20one&rft.au=Fustolo-Gunnink,%20S%20F&rft.date=2016-05-13&rft.volume=11&rft.issue=5&rft.spage=e0154853&rft.epage=e0154853&rft.pages=e0154853-e0154853&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0154853&rft_dat=%3Cgale_plos_%3EA453370152%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1788715861&rft_id=info:pmid/27177157&rft_galeid=A453370152&rft_doaj_id=oai_doaj_org_article_3ef2e800a2a64493953fda3d83a684a1&rfr_iscdi=true |