Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs

We have successfully established and characterized a genetically modified pig line with ubiquitous expression of LEA29Y, a human CTLA4-Ig derivate. LEA29Y binds human B7.1/CD80 and B7.2/CD86 with high affinity and is thus a potent inhibitor of T cell co-stimulation via this pathway. We have characte...

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Veröffentlicht in:	PloS one 2016-05, Vol.11 (5), p.e0155676-e0155676
Hauptverfasser:	Bähr, Andrea, Käser, Tobias, Kemter, Elisabeth, Gerner, Wilhelm, Kurome, Mayuko, Baars, Wiebke, Herbach, Nadja, Witter, Kirsti, Wünsch, Annegret, Talker, Stephanie C, Kessler, Barbara, Nagashima, Hiroshi, Saalmüller, Armin, Schwinzer, Reinhard, Wolf, Eckhard, Klymiuk, Nikolai
Format:	Artikel
Sprache:	eng
Schlagworte:	Abatacept - metabolism Analysis Animals Animals, Genetically Modified Antigen-Presenting Cells - metabolism B7 antigen Biological activity Biology and Life Sciences Biotechnology Breeding Breeding methods Breeding of animals CD80 antigen CD86 antigen Cloning, Organism Conserved Sequence Crosses, Genetic CTLA-4 protein Dendritic cells Female Fertilization in Vitro Gene expression Genetic aspects Genetic modification Genetically modified animals Hogs Humans Immune system Immunoglobulins Immunology Laboratories Lymph Nodes - pathology Lymphocyte Activation - immunology Lymphocytes Lymphocytes T Male Medicine and Health Sciences Mode of action Organs Pancreas Physiological aspects Promoter Regions, Genetic - genetics Protein Binding Reproduction Reproduction (biology) Reproduction - genetics Research and Analysis Methods Sexual maturity Sexual reproduction Stimulation Sus scrofa - genetics Sus scrofa - immunology Swine T cells T-Lymphocytes - immunology Tissues Transplants & implants Trinucleotide repeats Veterinary medicine Xenotransplantation
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