Neuregulin-1 Administration Protocols Sufficient for Stimulating Cardiac Regeneration in Young Mice Do Not Induce Somatic, Organ, or Neoplastic Growth

We previously developed and validated a strategy for stimulating heart regeneration by administration of recombinant neuregulin (rNRG1), a growth factor, in mice. rNRG1 stimulated proliferation of heart muscle cells, cardiomyocytes, and was most effective when administration began during the neonata...

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Veröffentlicht in:	PloS one 2016-05, Vol.11 (5), p.e0155456
Hauptverfasser:	Ganapathy, Balakrishnan, Nandhagopal, Nikitha, Polizzotti, Brian D, Bennett, David, Asan, Alparslan, Wu, Yijen, Kühn, Bernhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Amino acids Animals Animals, Newborn Antineoplastic agents Biology Biology and Life Sciences Body weight Brain Cancer Cardiac muscle Cardiology Cardiomyocytes Cardiovascular disease Care and treatment Cell cycle Cell proliferation Clinical trials Cynops pyrrhogaster Dosage and administration Enzyme-linked immunosorbent assay Epidermal growth factor ErbB protein ErbB Receptors - genetics ErbB Receptors - metabolism ErbB-2 protein ErbB-3 protein Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism Gene Expression Regulation - drug effects Health aspects Heart Heart - drug effects Heart - physiology Heart diseases Heart failure Hospitals Human populations Humans Inspection Kidney - drug effects Kidney - enzymology Kidneys Kinases Liver Lungs Magnetic resonance imaging Medicine Medicine and Health Sciences Mice Morphogenesis - drug effects Muscles Neonates Neoplasms - pathology Neuregulin Neuregulin 1 Neuregulin-1 - administration & dosage Neuregulin-1 - blood Neuregulin-1 - genetics Neuregulin-1 - pharmacology Organ Size - drug effects Pediatrics Phosphorylation - drug effects Physical Sciences Polymerase chain reaction Receptors Recombinant Proteins - pharmacology Regeneration Regeneration - drug effects Research and Analysis Methods Ribosomal Protein S6 Kinases - metabolism Rodents Spinal cord Spleen Studies Tibia Weighing
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