Losartan Attenuates Myocardial Endothelial-To-Mesenchymal Transition in Spontaneous Hypertensive Rats via Inhibiting TGF-β/Smad Signaling

Losartan plays an important role in the inhibition of myocardial fibrosis. But the underlying mechanism is not entirely clear. Emerging evidences have indicated that endothelial-to-mesenchymal transition (EndMT) plays a crucial role in cardiac fibrosis. Here the present study aims to first investiga...

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Veröffentlicht in:	PloS one 2016-05, Vol.11 (5), p.e0155730-e0155730
Hauptverfasser:	Wu, Miao, Peng, Zhenyu, Zu, Changhao, Ma, Jing, Lu, Shijuan, Zhong, Jianghua, Zhang, Saidan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology and Life Sciences Blood pressure Blood Pressure - drug effects Blotting, Western Body Weight - drug effects Calcium-Binding Proteins - metabolism Cardiology Cardiomyopathy Collagen Collagen Type I - metabolism Diabetes Electrocardiography Endothelium - drug effects Endothelium - metabolism Endothelium - pathology Fibroblasts Fibrosis Heart Heart attacks Heart diseases Heart failure Heart Rate - drug effects Heart Ventricles - drug effects Heart Ventricles - pathology Hypertension Immunofluorescence Inhibition Losartan - pharmacology Medicine and Health Sciences Mesenchyme Mesoderm - drug effects Mesoderm - metabolism Mesoderm - pathology Microscopy, Confocal Myocardium - metabolism Myocardium - pathology Organ Size - drug effects Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Prazosin Rats Rats, Inbred SHR Rats, Inbred WKY Rodents Signal Transduction - drug effects Signaling Smad protein Smad Proteins - metabolism Staining and Labeling Studies Transforming Growth Factor beta - metabolism
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