Cytokine Profiles in Human Metapneumovirus Infected Children: Identification of Genes Involved in the Antiviral Response and Pathogenesis

Human metapneumovirus (hMPV) causes severe airway infection in children that may be caused by an unfavorable immune response. The nature of the innate immune response to hMPV in naturally occurring infections in children is largely undescribed, and it is unknown if inflammasome activation is implica...

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Veröffentlicht in:	PloS one 2016-05, Vol.11 (5), p.e0155484-e0155484
Hauptverfasser:	Malmo, Jostein, Moe, Nina, Krokstad, Sidsel, Ryan, Liv, Loevenich, Simon, Johnsen, Ingvild B, Espevik, Terje, Nordbø, Svein Arne, Døllner, Henrik, Anthonsen, Marit W
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Antiviral drugs Biology and Life Sciences Blood Blood plasma Case-Control Studies Chemokines Child Child, Preschool Children Cytokines Cytokines - genetics Cytokines - metabolism Cytotoxicity Development and progression Female Gene expression Gene Expression Regulation - drug effects Gene regulation Genes Genetic aspects Genotype Hospitalization Hospitals Human behavior Human metapneumovirus Humans Immune response Immune system Immunoassay Infant Infections Inflammasomes Inflammasomes - genetics Inflammasomes - metabolism Inflammation Influenza Innate immunity Interferon Interferons - genetics Interferons - metabolism Interleukin 18 IP-10 protein Kinases Laboratories Lung diseases Male Medical research Medicine Medicine and Health Sciences Metapneumovirus - drug effects Metapneumovirus - pathogenicity mRNA Multiplexing Nasopharynx Nasopharynx - pathology Nasopharynx - virology Paramyxoviridae Infections - blood Paramyxoviridae Infections - drug therapy Paramyxoviridae Infections - genetics Paramyxoviridae Infections - virology Pathogenesis Pathogens People and Places Physiological aspects Plasma proteins Proteins Respiratory syncytial virus Respiratory tract RNA virus infections Science Secretions Studies Viruses Womens health
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