Association of Plasma Transforming Growth Factor-β1 Levels and the Risk of Atrial Fibrillation: A Meta-Analysis

Numerous studies have demonstrated that plasma transforming growth factor-β1 (TGF-β1) may be involved in the pathogenesis of atrial fibrillation (AF), but some discrepancy remained. We performed a meta-analysis to evaluate the association between the plasma level of TGF-β1 and the risk of AF. Publis...

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Veröffentlicht in:PloS one 2016-05, Vol.11 (5), p.e0155275-e0155275
Hauptverfasser: Li, Jiao, Yang, Yajuan, Ng, Chee Yuan, Zhang, Zhiwei, Liu, Tong, Li, Guangping
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Li, Guangping
description Numerous studies have demonstrated that plasma transforming growth factor-β1 (TGF-β1) may be involved in the pathogenesis of atrial fibrillation (AF), but some discrepancy remained. We performed a meta-analysis to evaluate the association between the plasma level of TGF-β1 and the risk of AF. Published clinical studies evaluating the association between the plasma level of TGF-β1 and the risk of AF were retrieved from PubMed and EMBASE databases. Two reviewers independently evaluated the quality of the included studies and extracted study data. Subgroup analysis and sensitivity analysis were performed to evaluate for heterogeneity between studies. Of the 395 studies identified initially, 13 studies were included into our analysis, with a total of 3354 patients. Higher plasma level of TGF-β1 was associated with increased risk of AF when evaluated as both a continuous variable (SMD 0.67; 95%CI 0.29-1.05) and a categorical variable (OR 1.01, 95% CI 1.01-1.02). This meta-analysis suggests an association between elevated plasma TGF-β1 and new onset AF. Additional studies with larger sample sizes are needed to further investigate the relationship between plasma TGF-β1 and the occurrence of AF.
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We performed a meta-analysis to evaluate the association between the plasma level of TGF-β1 and the risk of AF. Published clinical studies evaluating the association between the plasma level of TGF-β1 and the risk of AF were retrieved from PubMed and EMBASE databases. Two reviewers independently evaluated the quality of the included studies and extracted study data. Subgroup analysis and sensitivity analysis were performed to evaluate for heterogeneity between studies. Of the 395 studies identified initially, 13 studies were included into our analysis, with a total of 3354 patients. Higher plasma level of TGF-β1 was associated with increased risk of AF when evaluated as both a continuous variable (SMD 0.67; 95%CI 0.29-1.05) and a categorical variable (OR 1.01, 95% CI 1.01-1.02). This meta-analysis suggests an association between elevated plasma TGF-β1 and new onset AF. Additional studies with larger sample sizes are needed to further investigate the relationship between plasma TGF-β1 and the occurrence of AF.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27171383</pmid><doi>10.1371/journal.pone.0155275</doi><oa>free_for_read</oa></addata></record>
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subjects Atrial Fibrillation - blood
Atrial Fibrillation - epidemiology
Biology and life sciences
Cardiac arrhythmia
Cardiology
Cardiovascular disease
Catheters
Cohort analysis
Confounding Factors (Epidemiology)
Continuity (mathematics)
Data processing
Female
Fibrillation
Growth factors
Hospitals
Humans
Laboratories
Male
Medicine and Health Sciences
Meta-analysis
Multivariate Analysis
Pathogenesis
Physical Sciences
Plasma
Research and Analysis Methods
Risk
Risk Factors
Sensitivity analysis
Sensitivity and Specificity
Studies
Transforming Growth Factor beta1 - blood
Transforming growth factor-b1
Variables
title Association of Plasma Transforming Growth Factor-β1 Levels and the Risk of Atrial Fibrillation: A Meta-Analysis
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