Association of Plasma Transforming Growth Factor-β1 Levels and the Risk of Atrial Fibrillation: A Meta-Analysis
Numerous studies have demonstrated that plasma transforming growth factor-β1 (TGF-β1) may be involved in the pathogenesis of atrial fibrillation (AF), but some discrepancy remained. We performed a meta-analysis to evaluate the association between the plasma level of TGF-β1 and the risk of AF. Publis...
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description | Numerous studies have demonstrated that plasma transforming growth factor-β1 (TGF-β1) may be involved in the pathogenesis of atrial fibrillation (AF), but some discrepancy remained. We performed a meta-analysis to evaluate the association between the plasma level of TGF-β1 and the risk of AF.
Published clinical studies evaluating the association between the plasma level of TGF-β1 and the risk of AF were retrieved from PubMed and EMBASE databases. Two reviewers independently evaluated the quality of the included studies and extracted study data. Subgroup analysis and sensitivity analysis were performed to evaluate for heterogeneity between studies.
Of the 395 studies identified initially, 13 studies were included into our analysis, with a total of 3354 patients. Higher plasma level of TGF-β1 was associated with increased risk of AF when evaluated as both a continuous variable (SMD 0.67; 95%CI 0.29-1.05) and a categorical variable (OR 1.01, 95% CI 1.01-1.02).
This meta-analysis suggests an association between elevated plasma TGF-β1 and new onset AF. Additional studies with larger sample sizes are needed to further investigate the relationship between plasma TGF-β1 and the occurrence of AF. |
doi_str_mv | 10.1371/journal.pone.0155275 |
format | Article |
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Published clinical studies evaluating the association between the plasma level of TGF-β1 and the risk of AF were retrieved from PubMed and EMBASE databases. Two reviewers independently evaluated the quality of the included studies and extracted study data. Subgroup analysis and sensitivity analysis were performed to evaluate for heterogeneity between studies.
Of the 395 studies identified initially, 13 studies were included into our analysis, with a total of 3354 patients. Higher plasma level of TGF-β1 was associated with increased risk of AF when evaluated as both a continuous variable (SMD 0.67; 95%CI 0.29-1.05) and a categorical variable (OR 1.01, 95% CI 1.01-1.02).
This meta-analysis suggests an association between elevated plasma TGF-β1 and new onset AF. Additional studies with larger sample sizes are needed to further investigate the relationship between plasma TGF-β1 and the occurrence of AF.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0155275</identifier><identifier>PMID: 27171383</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Atrial Fibrillation - blood ; Atrial Fibrillation - epidemiology ; Biology and life sciences ; Cardiac arrhythmia ; Cardiology ; Cardiovascular disease ; Catheters ; Cohort analysis ; Confounding Factors (Epidemiology) ; Continuity (mathematics) ; Data processing ; Female ; Fibrillation ; Growth factors ; Hospitals ; Humans ; Laboratories ; Male ; Medicine and Health Sciences ; Meta-analysis ; Multivariate Analysis ; Pathogenesis ; Physical Sciences ; Plasma ; Research and Analysis Methods ; Risk ; Risk Factors ; Sensitivity analysis ; Sensitivity and Specificity ; Studies ; Transforming Growth Factor beta1 - blood ; Transforming growth factor-b1 ; Variables</subject><ispartof>PloS one, 2016-05, Vol.11 (5), p.e0155275-e0155275</ispartof><rights>2016 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Li et al 2016 Li et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-5efcb9198e6533c7e966c661bfab04325ff44d34c21de5e7e17ef4760a1575d53</citedby><cites>FETCH-LOGICAL-c526t-5efcb9198e6533c7e966c661bfab04325ff44d34c21de5e7e17ef4760a1575d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865111/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865111/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27171383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hund, Thomas</contributor><creatorcontrib>Li, Jiao</creatorcontrib><creatorcontrib>Yang, Yajuan</creatorcontrib><creatorcontrib>Ng, Chee Yuan</creatorcontrib><creatorcontrib>Zhang, Zhiwei</creatorcontrib><creatorcontrib>Liu, Tong</creatorcontrib><creatorcontrib>Li, Guangping</creatorcontrib><title>Association of Plasma Transforming Growth Factor-β1 Levels and the Risk of Atrial Fibrillation: A Meta-Analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Numerous studies have demonstrated that plasma transforming growth factor-β1 (TGF-β1) may be involved in the pathogenesis of atrial fibrillation (AF), but some discrepancy remained. We performed a meta-analysis to evaluate the association between the plasma level of TGF-β1 and the risk of AF.
Published clinical studies evaluating the association between the plasma level of TGF-β1 and the risk of AF were retrieved from PubMed and EMBASE databases. Two reviewers independently evaluated the quality of the included studies and extracted study data. Subgroup analysis and sensitivity analysis were performed to evaluate for heterogeneity between studies.
Of the 395 studies identified initially, 13 studies were included into our analysis, with a total of 3354 patients. Higher plasma level of TGF-β1 was associated with increased risk of AF when evaluated as both a continuous variable (SMD 0.67; 95%CI 0.29-1.05) and a categorical variable (OR 1.01, 95% CI 1.01-1.02).
This meta-analysis suggests an association between elevated plasma TGF-β1 and new onset AF. Additional studies with larger sample sizes are needed to further investigate the relationship between plasma TGF-β1 and the occurrence of AF.</description><subject>Atrial Fibrillation - blood</subject><subject>Atrial Fibrillation - epidemiology</subject><subject>Biology and life sciences</subject><subject>Cardiac arrhythmia</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Catheters</subject><subject>Cohort analysis</subject><subject>Confounding Factors (Epidemiology)</subject><subject>Continuity (mathematics)</subject><subject>Data processing</subject><subject>Female</subject><subject>Fibrillation</subject><subject>Growth factors</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Multivariate Analysis</subject><subject>Pathogenesis</subject><subject>Physical Sciences</subject><subject>Plasma</subject><subject>Research and Analysis Methods</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Sensitivity analysis</subject><subject>Sensitivity and Specificity</subject><subject>Studies</subject><subject>Transforming Growth Factor beta1 - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Jiao</au><au>Yang, Yajuan</au><au>Ng, Chee Yuan</au><au>Zhang, Zhiwei</au><au>Liu, Tong</au><au>Li, Guangping</au><au>Hund, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Plasma Transforming Growth Factor-β1 Levels and the Risk of Atrial Fibrillation: A Meta-Analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-05-12</date><risdate>2016</risdate><volume>11</volume><issue>5</issue><spage>e0155275</spage><epage>e0155275</epage><pages>e0155275-e0155275</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Numerous studies have demonstrated that plasma transforming growth factor-β1 (TGF-β1) may be involved in the pathogenesis of atrial fibrillation (AF), but some discrepancy remained. We performed a meta-analysis to evaluate the association between the plasma level of TGF-β1 and the risk of AF.
Published clinical studies evaluating the association between the plasma level of TGF-β1 and the risk of AF were retrieved from PubMed and EMBASE databases. Two reviewers independently evaluated the quality of the included studies and extracted study data. Subgroup analysis and sensitivity analysis were performed to evaluate for heterogeneity between studies.
Of the 395 studies identified initially, 13 studies were included into our analysis, with a total of 3354 patients. Higher plasma level of TGF-β1 was associated with increased risk of AF when evaluated as both a continuous variable (SMD 0.67; 95%CI 0.29-1.05) and a categorical variable (OR 1.01, 95% CI 1.01-1.02).
This meta-analysis suggests an association between elevated plasma TGF-β1 and new onset AF. Additional studies with larger sample sizes are needed to further investigate the relationship between plasma TGF-β1 and the occurrence of AF.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27171383</pmid><doi>10.1371/journal.pone.0155275</doi><oa>free_for_read</oa></addata></record> |
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subjects | Atrial Fibrillation - blood Atrial Fibrillation - epidemiology Biology and life sciences Cardiac arrhythmia Cardiology Cardiovascular disease Catheters Cohort analysis Confounding Factors (Epidemiology) Continuity (mathematics) Data processing Female Fibrillation Growth factors Hospitals Humans Laboratories Male Medicine and Health Sciences Meta-analysis Multivariate Analysis Pathogenesis Physical Sciences Plasma Research and Analysis Methods Risk Risk Factors Sensitivity analysis Sensitivity and Specificity Studies Transforming Growth Factor beta1 - blood Transforming growth factor-b1 Variables |
title | Association of Plasma Transforming Growth Factor-β1 Levels and the Risk of Atrial Fibrillation: A Meta-Analysis |
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