The Effect of Inadequate Initial Empiric Antimicrobial Treatment on Mortality in Critically Ill Patients with Bloodstream Infections: A Multi-Centre Retrospective Cohort Study

Hospital mortality rates are elevated in critically ill patients with bloodstream infections. Given that mortality may be even higher if appropriate treatment is delayed, we sought to determine the effect of inadequate initial empiric treatment on mortality in these patients. A retrospective cohort...

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Veröffentlicht in:	PloS one 2016-05, Vol.11 (5), p.e0154944-e0154944
Hauptverfasser:	Savage, Rachel D, Fowler, Robert A, Rishu, Asgar H, Bagshaw, Sean M, Cook, Deborah, Dodek, Peter, Hall, Richard, Kumar, Anand, Lamontagne, François, Lauzier, François, Marshall, John, Martin, Claudio M, McIntyre, Lauralyn, Muscedere, John, Reynolds, Steven, Stelfox, Henry T, Daneman, Nick
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anti-infective agents Anti-Infective Agents - therapeutic use Antiinfectives and antibacterials Antimicrobial agents Bacteremia Bacteremia - drug therapy Bacteremia - mortality Biology and Life Sciences Blood culture Canada Candidemia Cohort analysis Confidence intervals Critical care Critically ill persons Diagnostic systems Drug resistance Drug therapy Epidemiology Ethics Female Fungemia - drug therapy Fungemia - mortality Health sciences Hospital Mortality Hospitals Humans Infections Intensive care Intensive Care Units Male Medical prognosis Medical research Medicine Medicine and Health Sciences Middle Aged Mortality Patient outcomes Patients People and Places Regression models Retrospective Studies Risk factors Sepsis Statistical analysis Subgroups Systematic review Therapy
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