Behavioral, Ventilatory and Thermoregulatory Responses to Hypercapnia and Hypoxia in the Wistar Audiogenic Rat (WAR) Strain
We investigated the behavioral, respiratory, and thermoregulatory responses elicited by acute exposure to both hypercapnic and hypoxic environments in Wistar audiogenic rats (WARs). The WAR strain represents a genetic animal model of epilepsy. Behavioral analyses were performed using neuroethologica...
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| creator | Granjeiro, Érica Maria da Silva, Glauber S F Giusti, Humberto Oliveira, José Antonio Glass, Mogens Lesner Garcia-Cairasco, Norberto |
| description | We investigated the behavioral, respiratory, and thermoregulatory responses elicited by acute exposure to both hypercapnic and hypoxic environments in Wistar audiogenic rats (WARs). The WAR strain represents a genetic animal model of epilepsy.
Behavioral analyses were performed using neuroethological methods, and flowcharts were constructed to illustrate behavioral findings. The body plethysmography method was used to obtain pulmonary ventilation (VE) measurements, and body temperature (Tb) measurements were taken via temperature sensors implanted in the abdominal cavities of the animals.
No significant difference was observed between the WAR and Wistar control group with respect to the thermoregulatory response elicited by exposure to both acute hypercapnia and acute hypoxia (p>0.05). However, we found that the VE of WARs was attenuated relative to that of Wistar control animals during exposure to both hypercapnic (WAR: 133 ± 11% vs. Wistar: 243 ± 23%, p |
| doi_str_mv | 10.1371/journal.pone.0154141 |
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Behavioral analyses were performed using neuroethological methods, and flowcharts were constructed to illustrate behavioral findings. The body plethysmography method was used to obtain pulmonary ventilation (VE) measurements, and body temperature (Tb) measurements were taken via temperature sensors implanted in the abdominal cavities of the animals.
No significant difference was observed between the WAR and Wistar control group with respect to the thermoregulatory response elicited by exposure to both acute hypercapnia and acute hypoxia (p>0.05). However, we found that the VE of WARs was attenuated relative to that of Wistar control animals during exposure to both hypercapnic (WAR: 133 ± 11% vs. Wistar: 243 ± 23%, p<0.01) and hypoxic conditions (WAR: 138 ± 8% vs. Wistar: 177 ± 8%; p<0.01). In addition, we noted that this ventilatory attenuation was followed by alterations in the behavioral responses of these animals.
Our results indicate that WARs, a genetic model of epilepsy, have important alterations in their ability to compensate for changes in levels of various arterial blood gasses. WARs present an attenuated ventilatory response to an increased PaCO2 or decreased PaO2, coupled to behavioral changes, which make them a suitable model to further study respiratory risks associated to epilepsy.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0154141</identifier><identifier>PMID: 27149672</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Animals ; Attenuation ; Behavior, Animal - physiology ; Biology and Life Sciences ; Body temperature ; Body Temperature Regulation - physiology ; Care and treatment ; Disease Models, Animal ; Epilepsy ; Epilepsy, Reflex - physiopathology ; Epilepsy, Reflex - psychology ; Exposure ; Hypercapnia ; Hypercapnia - physiopathology ; Hypercapnia - psychology ; Hypoxia ; Hypoxia - physiopathology ; Hypoxia - psychology ; Male ; Measuring instruments ; Medicine ; Medicine and Health Sciences ; Neuroethology ; Neurosciences ; Physical Sciences ; Physiology ; Plethysmography ; Pulmonary ventilation ; Rats ; Rats, Wistar ; Research and Analysis Methods ; Respiratory Physiological Phenomena ; Rodents ; Sensors ; Serotonin ; Temperature sensors ; Ventilation ; Ventilatory behavior ; War</subject><ispartof>PloS one, 2016-05, Vol.11 (5), p.e0154141-e0154141</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Granjeiro et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Granjeiro et al 2016 Granjeiro et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-a325530bb62342debd53c574a612dc691f81c3f0c8a530c69a1198ce8cb006dc3</citedby><cites>FETCH-LOGICAL-c692t-a325530bb62342debd53c574a612dc691f81c3f0c8a530c69a1198ce8cb006dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858153/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858153/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27149672$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Granjeiro, Érica Maria</creatorcontrib><creatorcontrib>da Silva, Glauber S F</creatorcontrib><creatorcontrib>Giusti, Humberto</creatorcontrib><creatorcontrib>Oliveira, José Antonio</creatorcontrib><creatorcontrib>Glass, Mogens Lesner</creatorcontrib><creatorcontrib>Garcia-Cairasco, Norberto</creatorcontrib><title>Behavioral, Ventilatory and Thermoregulatory Responses to Hypercapnia and Hypoxia in the Wistar Audiogenic Rat (WAR) Strain</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>We investigated the behavioral, respiratory, and thermoregulatory responses elicited by acute exposure to both hypercapnic and hypoxic environments in Wistar audiogenic rats (WARs). The WAR strain represents a genetic animal model of epilepsy.
Behavioral analyses were performed using neuroethological methods, and flowcharts were constructed to illustrate behavioral findings. The body plethysmography method was used to obtain pulmonary ventilation (VE) measurements, and body temperature (Tb) measurements were taken via temperature sensors implanted in the abdominal cavities of the animals.
No significant difference was observed between the WAR and Wistar control group with respect to the thermoregulatory response elicited by exposure to both acute hypercapnia and acute hypoxia (p>0.05). However, we found that the VE of WARs was attenuated relative to that of Wistar control animals during exposure to both hypercapnic (WAR: 133 ± 11% vs. Wistar: 243 ± 23%, p<0.01) and hypoxic conditions (WAR: 138 ± 8% vs. Wistar: 177 ± 8%; p<0.01). In addition, we noted that this ventilatory attenuation was followed by alterations in the behavioral responses of these animals.
Our results indicate that WARs, a genetic model of epilepsy, have important alterations in their ability to compensate for changes in levels of various arterial blood gasses. WARs present an attenuated ventilatory response to an increased PaCO2 or decreased PaO2, coupled to behavioral changes, which make them a suitable model to further study respiratory risks associated to epilepsy.</description><subject>Analysis</subject><subject>Animals</subject><subject>Attenuation</subject><subject>Behavior, Animal - physiology</subject><subject>Biology and Life Sciences</subject><subject>Body temperature</subject><subject>Body Temperature Regulation - physiology</subject><subject>Care and treatment</subject><subject>Disease Models, Animal</subject><subject>Epilepsy</subject><subject>Epilepsy, Reflex - physiopathology</subject><subject>Epilepsy, Reflex - psychology</subject><subject>Exposure</subject><subject>Hypercapnia</subject><subject>Hypercapnia - physiopathology</subject><subject>Hypercapnia - psychology</subject><subject>Hypoxia</subject><subject>Hypoxia - physiopathology</subject><subject>Hypoxia - psychology</subject><subject>Male</subject><subject>Measuring 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Ventilatory and Thermoregulatory Responses to Hypercapnia and Hypoxia in the Wistar Audiogenic Rat (WAR) Strain</title><author>Granjeiro, Érica Maria ; da Silva, Glauber S F ; Giusti, Humberto ; Oliveira, José Antonio ; Glass, Mogens Lesner ; Garcia-Cairasco, Norberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-a325530bb62342debd53c574a612dc691f81c3f0c8a530c69a1198ce8cb006dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Analysis</topic><topic>Animals</topic><topic>Attenuation</topic><topic>Behavior, Animal - physiology</topic><topic>Biology and Life Sciences</topic><topic>Body temperature</topic><topic>Body Temperature Regulation - physiology</topic><topic>Care and treatment</topic><topic>Disease Models, Animal</topic><topic>Epilepsy</topic><topic>Epilepsy, Reflex - physiopathology</topic><topic>Epilepsy, Reflex - 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Granjeiro, Érica Maria</au><au>da Silva, Glauber S F</au><au>Giusti, Humberto</au><au>Oliveira, José Antonio</au><au>Glass, Mogens Lesner</au><au>Garcia-Cairasco, Norberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Behavioral, Ventilatory and Thermoregulatory Responses to Hypercapnia and Hypoxia in the Wistar Audiogenic Rat (WAR) Strain</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-05-05</date><risdate>2016</risdate><volume>11</volume><issue>5</issue><spage>e0154141</spage><epage>e0154141</epage><pages>e0154141-e0154141</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>We investigated the behavioral, respiratory, and thermoregulatory responses elicited by acute exposure to both hypercapnic and hypoxic environments in Wistar audiogenic rats (WARs). The WAR strain represents a genetic animal model of epilepsy.
Behavioral analyses were performed using neuroethological methods, and flowcharts were constructed to illustrate behavioral findings. The body plethysmography method was used to obtain pulmonary ventilation (VE) measurements, and body temperature (Tb) measurements were taken via temperature sensors implanted in the abdominal cavities of the animals.
No significant difference was observed between the WAR and Wistar control group with respect to the thermoregulatory response elicited by exposure to both acute hypercapnia and acute hypoxia (p>0.05). However, we found that the VE of WARs was attenuated relative to that of Wistar control animals during exposure to both hypercapnic (WAR: 133 ± 11% vs. Wistar: 243 ± 23%, p<0.01) and hypoxic conditions (WAR: 138 ± 8% vs. Wistar: 177 ± 8%; p<0.01). In addition, we noted that this ventilatory attenuation was followed by alterations in the behavioral responses of these animals.
Our results indicate that WARs, a genetic model of epilepsy, have important alterations in their ability to compensate for changes in levels of various arterial blood gasses. WARs present an attenuated ventilatory response to an increased PaCO2 or decreased PaO2, coupled to behavioral changes, which make them a suitable model to further study respiratory risks associated to epilepsy.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27149672</pmid><doi>10.1371/journal.pone.0154141</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Animals Attenuation Behavior, Animal - physiology Biology and Life Sciences Body temperature Body Temperature Regulation - physiology Care and treatment Disease Models, Animal Epilepsy Epilepsy, Reflex - physiopathology Epilepsy, Reflex - psychology Exposure Hypercapnia Hypercapnia - physiopathology Hypercapnia - psychology Hypoxia Hypoxia - physiopathology Hypoxia - psychology Male Measuring instruments Medicine Medicine and Health Sciences Neuroethology Neurosciences Physical Sciences Physiology Plethysmography Pulmonary ventilation Rats Rats, Wistar Research and Analysis Methods Respiratory Physiological Phenomena Rodents Sensors Serotonin Temperature sensors Ventilation Ventilatory behavior War |
| title | Behavioral, Ventilatory and Thermoregulatory Responses to Hypercapnia and Hypoxia in the Wistar Audiogenic Rat (WAR) Strain |
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