Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems
To determine the mechanisms of speech intelligibility impairment due to neurologic impairments, intelligibility decline was modeled as a function of co-occurring changes in the articulatory, resonatory, phonatory, and respiratory subsystems. Sixty-six individuals diagnosed with amyotrophic lateral s...
Gespeichert in:
| Veröffentlicht in: | PloS one 2016-05, Vol.11 (5), p.e0154971 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 5 |
| container_start_page | e0154971 |
| container_title | PloS one |
| container_volume | 11 |
| creator | Rong, Panying Yunusova, Yana Wang, Jun Zinman, Lorne Pattee, Gary L Berry, James D Perry, Bridget Green, Jordan R |
| description | To determine the mechanisms of speech intelligibility impairment due to neurologic impairments, intelligibility decline was modeled as a function of co-occurring changes in the articulatory, resonatory, phonatory, and respiratory subsystems.
Sixty-six individuals diagnosed with amyotrophic lateral sclerosis (ALS) were studied longitudinally. The disease-related changes in articulatory, resonatory, phonatory, and respiratory subsystems were quantified using multiple instrumental measures, which were subjected to a principal component analysis and mixed effects models to derive a set of speech subsystem predictors. A stepwise approach was used to select the best set of subsystem predictors to model the overall decline in intelligibility.
Intelligibility was modeled as a function of five predictors that corresponded to velocities of lip and jaw movements (articulatory), number of syllable repetitions in the alternating motion rate task (articulatory), nasal airflow (resonatory), maximum fundamental frequency (phonatory), and speech pauses (respiratory). The model accounted for 95.6% of the variance in intelligibility, among which the articulatory predictors showed the most substantial independent contribution (57.7%).
Articulatory impairments characterized by reduced velocities of lip and jaw movements and resonatory impairments characterized by increased nasal airflow served as the subsystem predictors of the longitudinal decline of speech intelligibility in ALS. Declines in maximum performance tasks such as the alternating motion rate preceded declines in intelligibility, thus serving as early predictors of bulbar dysfunction. Following the rapid decline in speech intelligibility, a precipitous decline in maximum performance tasks subsequently occurred. |
| doi_str_mv | 10.1371/journal.pone.0154971 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1787084073</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A453370651</galeid><doaj_id>oai_doaj_org_article_77881a26470a446799749f411901ca5d</doaj_id><sourcerecordid>A453370651</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-3f28ccdeea1a5732f70d61beaeb7e5fc4cdbd73cdbbb752dab120917c23f85c03</originalsourceid><addsrcrecordid>eNqNk92K1DAUx4so7rr6BqIFQfRixqRJm_ZGGNevgYEVR70NaXLaZmibMUkX5wF8b1Onu0xlL6TQhpPf-Z-eryh6itESE4bf7Mxge9Eu96aHJcIpLRi-F53jgiSLLEHk_sn5LHrk3A6hlORZ9jA6SximeZGx8-j3FwtKS6_7Ot7uAWQTr3sPbatrXepW-0P8HmSre4h1H6-6g_HW7Bst443wYEUbb2UL1jjt4nfCgYpNH_sGgle41sYKr4PFVEFW6WuthtHlGGg7lO7gPHTucfSgEq2DJ9P3Ivr-8cO3y8-LzdWn9eVqs5BZkfgFqZJcSgUgsEgZSSqGVIZLEFAySCtJpSoVI-FdlixNlChxggrMZEKqPJWIXETPj7r71jg-VdBxzHKGcooYCcT6SCgjdnxvdSfsgRuh-V-DsTUX1uuQM2csz7FIMsqQoDRjRcFoUVGMC4SlSFXQejtFG8oOlITeh4LNROc3vW54ba45zdMc5zgIvJoErPk5gPO8006G5ogezHD8b8ryhGQBffEPend2E1WLkIDuq9BNIUdRvqIpIQxl6Rh2eQcVHgWdlmHcKh3sM4fXM4fAePjlazE4x9fbr__PXv2Ysy9P2AZE6xtn2mEcKTcH6RGUYRKdheq2yBjxcVtuqsHHbeHTtgS3Z6cNunW6WQ_yBy_WEaI</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1787084073</pqid></control><display><type>article</type><title>Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Rong, Panying ; Yunusova, Yana ; Wang, Jun ; Zinman, Lorne ; Pattee, Gary L ; Berry, James D ; Perry, Bridget ; Green, Jordan R</creator><creatorcontrib>Rong, Panying ; Yunusova, Yana ; Wang, Jun ; Zinman, Lorne ; Pattee, Gary L ; Berry, James D ; Perry, Bridget ; Green, Jordan R</creatorcontrib><description>To determine the mechanisms of speech intelligibility impairment due to neurologic impairments, intelligibility decline was modeled as a function of co-occurring changes in the articulatory, resonatory, phonatory, and respiratory subsystems.
Sixty-six individuals diagnosed with amyotrophic lateral sclerosis (ALS) were studied longitudinally. The disease-related changes in articulatory, resonatory, phonatory, and respiratory subsystems were quantified using multiple instrumental measures, which were subjected to a principal component analysis and mixed effects models to derive a set of speech subsystem predictors. A stepwise approach was used to select the best set of subsystem predictors to model the overall decline in intelligibility.
Intelligibility was modeled as a function of five predictors that corresponded to velocities of lip and jaw movements (articulatory), number of syllable repetitions in the alternating motion rate task (articulatory), nasal airflow (resonatory), maximum fundamental frequency (phonatory), and speech pauses (respiratory). The model accounted for 95.6% of the variance in intelligibility, among which the articulatory predictors showed the most substantial independent contribution (57.7%).
Articulatory impairments characterized by reduced velocities of lip and jaw movements and resonatory impairments characterized by increased nasal airflow served as the subsystem predictors of the longitudinal decline of speech intelligibility in ALS. Declines in maximum performance tasks such as the alternating motion rate preceded declines in intelligibility, thus serving as early predictors of bulbar dysfunction. Following the rapid decline in speech intelligibility, a precipitous decline in maximum performance tasks subsequently occurred.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0154971</identifier><identifier>PMID: 27148967</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acoustics ; Adult ; Aged ; Air flow ; Airflow ; Amyotrophic lateral sclerosis ; Amyotrophic Lateral Sclerosis - physiopathology ; Analysis ; Biology and Life Sciences ; Communication ; Complications and side effects ; Demographic aspects ; Disease Progression ; Female ; Health aspects ; Humans ; Intelligibility ; Jaw ; Lip ; Male ; Mathematical models ; Medicine and Health Sciences ; Middle Aged ; Movement - physiology ; Phonation - physiology ; Physical Sciences ; Physiological aspects ; Principal components analysis ; Psychological aspects ; Research and Analysis Methods ; Respiration ; Social Sciences ; Speech ; Speech - physiology ; Speech disorders ; Speech Disorders - physiopathology ; Speech Intelligibility - physiology ; Speech perception ; Speech therapy ; Studies</subject><ispartof>PloS one, 2016-05, Vol.11 (5), p.e0154971</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Rong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Rong et al 2016 Rong et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-3f28ccdeea1a5732f70d61beaeb7e5fc4cdbd73cdbbb752dab120917c23f85c03</citedby><cites>FETCH-LOGICAL-c692t-3f28ccdeea1a5732f70d61beaeb7e5fc4cdbd73cdbbb752dab120917c23f85c03</cites><orcidid>0000-0001-7067-0083</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858181/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858181/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27148967$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rong, Panying</creatorcontrib><creatorcontrib>Yunusova, Yana</creatorcontrib><creatorcontrib>Wang, Jun</creatorcontrib><creatorcontrib>Zinman, Lorne</creatorcontrib><creatorcontrib>Pattee, Gary L</creatorcontrib><creatorcontrib>Berry, James D</creatorcontrib><creatorcontrib>Perry, Bridget</creatorcontrib><creatorcontrib>Green, Jordan R</creatorcontrib><title>Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To determine the mechanisms of speech intelligibility impairment due to neurologic impairments, intelligibility decline was modeled as a function of co-occurring changes in the articulatory, resonatory, phonatory, and respiratory subsystems.
Sixty-six individuals diagnosed with amyotrophic lateral sclerosis (ALS) were studied longitudinally. The disease-related changes in articulatory, resonatory, phonatory, and respiratory subsystems were quantified using multiple instrumental measures, which were subjected to a principal component analysis and mixed effects models to derive a set of speech subsystem predictors. A stepwise approach was used to select the best set of subsystem predictors to model the overall decline in intelligibility.
Intelligibility was modeled as a function of five predictors that corresponded to velocities of lip and jaw movements (articulatory), number of syllable repetitions in the alternating motion rate task (articulatory), nasal airflow (resonatory), maximum fundamental frequency (phonatory), and speech pauses (respiratory). The model accounted for 95.6% of the variance in intelligibility, among which the articulatory predictors showed the most substantial independent contribution (57.7%).
Articulatory impairments characterized by reduced velocities of lip and jaw movements and resonatory impairments characterized by increased nasal airflow served as the subsystem predictors of the longitudinal decline of speech intelligibility in ALS. Declines in maximum performance tasks such as the alternating motion rate preceded declines in intelligibility, thus serving as early predictors of bulbar dysfunction. Following the rapid decline in speech intelligibility, a precipitous decline in maximum performance tasks subsequently occurred.</description><subject>Acoustics</subject><subject>Adult</subject><subject>Aged</subject><subject>Air flow</subject><subject>Airflow</subject><subject>Amyotrophic lateral sclerosis</subject><subject>Amyotrophic Lateral Sclerosis - physiopathology</subject><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Communication</subject><subject>Complications and side effects</subject><subject>Demographic aspects</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Intelligibility</subject><subject>Jaw</subject><subject>Lip</subject><subject>Male</subject><subject>Mathematical models</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Movement - physiology</subject><subject>Phonation - physiology</subject><subject>Physical Sciences</subject><subject>Physiological aspects</subject><subject>Principal components analysis</subject><subject>Psychological aspects</subject><subject>Research and Analysis Methods</subject><subject>Respiration</subject><subject>Social Sciences</subject><subject>Speech</subject><subject>Speech - physiology</subject><subject>Speech disorders</subject><subject>Speech Disorders - physiopathology</subject><subject>Speech Intelligibility - physiology</subject><subject>Speech perception</subject><subject>Speech therapy</subject><subject>Studies</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk92K1DAUx4so7rr6BqIFQfRixqRJm_ZGGNevgYEVR70NaXLaZmibMUkX5wF8b1Onu0xlL6TQhpPf-Z-eryh6itESE4bf7Mxge9Eu96aHJcIpLRi-F53jgiSLLEHk_sn5LHrk3A6hlORZ9jA6SximeZGx8-j3FwtKS6_7Ot7uAWQTr3sPbatrXepW-0P8HmSre4h1H6-6g_HW7Bst443wYEUbb2UL1jjt4nfCgYpNH_sGgle41sYKr4PFVEFW6WuthtHlGGg7lO7gPHTucfSgEq2DJ9P3Ivr-8cO3y8-LzdWn9eVqs5BZkfgFqZJcSgUgsEgZSSqGVIZLEFAySCtJpSoVI-FdlixNlChxggrMZEKqPJWIXETPj7r71jg-VdBxzHKGcooYCcT6SCgjdnxvdSfsgRuh-V-DsTUX1uuQM2csz7FIMsqQoDRjRcFoUVGMC4SlSFXQejtFG8oOlITeh4LNROc3vW54ba45zdMc5zgIvJoErPk5gPO8006G5ogezHD8b8ryhGQBffEPend2E1WLkIDuq9BNIUdRvqIpIQxl6Rh2eQcVHgWdlmHcKh3sM4fXM4fAePjlazE4x9fbr__PXv2Ysy9P2AZE6xtn2mEcKTcH6RGUYRKdheq2yBjxcVtuqsHHbeHTtgS3Z6cNunW6WQ_yBy_WEaI</recordid><startdate>20160505</startdate><enddate>20160505</enddate><creator>Rong, Panying</creator><creator>Yunusova, Yana</creator><creator>Wang, Jun</creator><creator>Zinman, Lorne</creator><creator>Pattee, Gary L</creator><creator>Berry, James D</creator><creator>Perry, Bridget</creator><creator>Green, Jordan R</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-7067-0083</orcidid></search><sort><creationdate>20160505</creationdate><title>Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems</title><author>Rong, Panying ; Yunusova, Yana ; Wang, Jun ; Zinman, Lorne ; Pattee, Gary L ; Berry, James D ; Perry, Bridget ; Green, Jordan R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-3f28ccdeea1a5732f70d61beaeb7e5fc4cdbd73cdbbb752dab120917c23f85c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acoustics</topic><topic>Adult</topic><topic>Aged</topic><topic>Air flow</topic><topic>Airflow</topic><topic>Amyotrophic lateral sclerosis</topic><topic>Amyotrophic Lateral Sclerosis - physiopathology</topic><topic>Analysis</topic><topic>Biology and Life Sciences</topic><topic>Communication</topic><topic>Complications and side effects</topic><topic>Demographic aspects</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Intelligibility</topic><topic>Jaw</topic><topic>Lip</topic><topic>Male</topic><topic>Mathematical models</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Movement - physiology</topic><topic>Phonation - physiology</topic><topic>Physical Sciences</topic><topic>Physiological aspects</topic><topic>Principal components analysis</topic><topic>Psychological aspects</topic><topic>Research and Analysis Methods</topic><topic>Respiration</topic><topic>Social Sciences</topic><topic>Speech</topic><topic>Speech - physiology</topic><topic>Speech disorders</topic><topic>Speech Disorders - physiopathology</topic><topic>Speech Intelligibility - physiology</topic><topic>Speech perception</topic><topic>Speech therapy</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rong, Panying</creatorcontrib><creatorcontrib>Yunusova, Yana</creatorcontrib><creatorcontrib>Wang, Jun</creatorcontrib><creatorcontrib>Zinman, Lorne</creatorcontrib><creatorcontrib>Pattee, Gary L</creatorcontrib><creatorcontrib>Berry, James D</creatorcontrib><creatorcontrib>Perry, Bridget</creatorcontrib><creatorcontrib>Green, Jordan R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rong, Panying</au><au>Yunusova, Yana</au><au>Wang, Jun</au><au>Zinman, Lorne</au><au>Pattee, Gary L</au><au>Berry, James D</au><au>Perry, Bridget</au><au>Green, Jordan R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-05-05</date><risdate>2016</risdate><volume>11</volume><issue>5</issue><spage>e0154971</spage><pages>e0154971-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To determine the mechanisms of speech intelligibility impairment due to neurologic impairments, intelligibility decline was modeled as a function of co-occurring changes in the articulatory, resonatory, phonatory, and respiratory subsystems.
Sixty-six individuals diagnosed with amyotrophic lateral sclerosis (ALS) were studied longitudinally. The disease-related changes in articulatory, resonatory, phonatory, and respiratory subsystems were quantified using multiple instrumental measures, which were subjected to a principal component analysis and mixed effects models to derive a set of speech subsystem predictors. A stepwise approach was used to select the best set of subsystem predictors to model the overall decline in intelligibility.
Intelligibility was modeled as a function of five predictors that corresponded to velocities of lip and jaw movements (articulatory), number of syllable repetitions in the alternating motion rate task (articulatory), nasal airflow (resonatory), maximum fundamental frequency (phonatory), and speech pauses (respiratory). The model accounted for 95.6% of the variance in intelligibility, among which the articulatory predictors showed the most substantial independent contribution (57.7%).
Articulatory impairments characterized by reduced velocities of lip and jaw movements and resonatory impairments characterized by increased nasal airflow served as the subsystem predictors of the longitudinal decline of speech intelligibility in ALS. Declines in maximum performance tasks such as the alternating motion rate preceded declines in intelligibility, thus serving as early predictors of bulbar dysfunction. Following the rapid decline in speech intelligibility, a precipitous decline in maximum performance tasks subsequently occurred.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27148967</pmid><doi>10.1371/journal.pone.0154971</doi><orcidid>https://orcid.org/0000-0001-7067-0083</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-05, Vol.11 (5), p.e0154971 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1787084073 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Acoustics Adult Aged Air flow Airflow Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - physiopathology Analysis Biology and Life Sciences Communication Complications and side effects Demographic aspects Disease Progression Female Health aspects Humans Intelligibility Jaw Lip Male Mathematical models Medicine and Health Sciences Middle Aged Movement - physiology Phonation - physiology Physical Sciences Physiological aspects Principal components analysis Psychological aspects Research and Analysis Methods Respiration Social Sciences Speech Speech - physiology Speech disorders Speech Disorders - physiopathology Speech Intelligibility - physiology Speech perception Speech therapy Studies |
| title | Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T01%3A23%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Predicting%20Speech%20Intelligibility%20Decline%20in%20Amyotrophic%20Lateral%20Sclerosis%20Based%20on%20the%20Deterioration%20of%20Individual%20Speech%20Subsystems&rft.jtitle=PloS%20one&rft.au=Rong,%20Panying&rft.date=2016-05-05&rft.volume=11&rft.issue=5&rft.spage=e0154971&rft.pages=e0154971-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0154971&rft_dat=%3Cgale_plos_%3EA453370651%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1787084073&rft_id=info:pmid/27148967&rft_galeid=A453370651&rft_doaj_id=oai_doaj_org_article_77881a26470a446799749f411901ca5d&rfr_iscdi=true |