A Regional Reduction in Ito and IKACh in the Murine Posterior Left Atrial Myocardium Is Associated with Action Potential Prolongation and Increased Ectopic Activity

The left atrial posterior wall (LAPW) is potentially an important area for the development and maintenance of atrial fibrillation. We assessed whether there are regional electrical differences throughout the murine left atrial myocardium that could underlie regional differences in arrhythmia suscept...

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Veröffentlicht in:	PloS one 2016-05, Vol.11 (5), p.e0154077-e0154077
Hauptverfasser:	Holmes, Andrew P, Yu, Ting Y, Tull, Samantha, Syeda, Fahima, Kuhlmann, Stefan M, O'Brien, Sian-Marie, Patel, Pushpa, Brain, Keith L, Pavlovic, Davor, Brown, Nigel A, Fabritz, Larissa, Kirchhof, Paulus
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Action Potentials - physiology Animals Arrhythmia Atrial Function - physiology Atrial Premature Complexes - physiopathology Atrium Biology and Life Sciences Cardiac arrhythmia Cardiomyocytes Catheters Electrophysiology Female Fibrillation G Protein-Coupled Inwardly-Rectifying Potassium Channels - analysis G Protein-Coupled Inwardly-Rectifying Potassium Channels - physiology Gene expression Gene mapping Heart Atria - chemistry Heart Atria - physiopathology Ion channels Ion Channels - analysis Ion Channels - physiology Kv1.4 Potassium Channel - analysis Kv1.4 Potassium Channel - physiology Male Mapping Medicine and Health Sciences Mice Microelectrodes Myocardium Myocytes, Cardiac - chemistry Myocytes, Cardiac - physiology Patch-Clamp Techniques Physical Sciences Prolongation Regional analysis Research and Analysis Methods Rodents Science Veins & arteries
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