Carbon Monoxide Releasing Molecule-A1 (CORM-A1) Improves Neurogenesis: Increase of Neuronal Differentiation Yield by Preventing Cell Death

Cerebral ischemia and neurodegenerative diseases lead to impairment or death of neurons in the central nervous system. Stem cell based therapies are promising strategies currently under investigation. Carbon monoxide (CO) is an endogenous product of heme degradation by heme oxygenase (HO) activity....

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Veröffentlicht in:	PloS one 2016-05, Vol.11 (5), p.e0154781
Hauptverfasser:	Almeida, Ana S, Soares, Nuno L, Vieira, Melissa, Gramsbergen, Jan Bert, Vieira, Helena L A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Bcl-2 protein Biology and Life Sciences Biosynthesis Boranes - pharmacology Brain slice preparation Cancer Carbon monoxide Carbonates - pharmacology Caspase Caspase 3 - metabolism Caspase-3 Cell death Cell Death - drug effects Cell Differentiation - drug effects Cell growth Cell Line Cell lines Cell number Cell proliferation Cell Proliferation - drug effects Central nervous system Differentiation Gene expression Heme Hippocampus Humans Inflammation Iodides Ischemia Low concentrations Mice Mice, Inbred BALB C Mortality mRNA Nestin Neurodegenerative diseases Neurogenesis Neurogenesis - drug effects Neurological diseases Neuromodulation Neurons Neurons - drug effects Neurons - metabolism Neurotrophin 2 Oxygen Oxygenase Propidium iodide Proto-Oncogene Proteins c-bcl-2 - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Receptors Research and Analysis Methods Retinoic acid Rodents Signaling Smooth muscle Stem cells Studies Tissues Yield
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