NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes

Regulation of gene expression is one of several roles proposed for the stress-induced nucleotide diadenosine tetraphosphate (Ap4A). We have examined this directly by a comparative RNA-Seq analysis of KBM-7 chronic myelogenous leukemia cells and KBM-7 cells in which the NUDT2 Ap4A hydrolase gene had...

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Veröffentlicht in:	PloS one 2016-05, Vol.11 (5), p.e0154674-e0154674
Hauptverfasser:	Marriott, Andrew S, Vasieva, Olga, Fang, Yongxiang, Copeland, Nikki A, McLennan, Alexander G, Jones, Nigel J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine triphosphate Anticancer properties Antigens Apoptosis Autocrine signalling Biochemistry Biology Biology and Life Sciences Cancer Catabolism Cell Line, Tumor Chromatin remodeling Chronic myeloid leukemia Deoxyribonucleic acid Dinucleoside Phosphates - metabolism DNA Down-Regulation E coli Enzymes Escherichia coli Functional morphology Gene expression Gene Expression Profiling Gene Knockout Techniques Gene regulation Genes Genomics Humans Hydrolase Immune response Immune system Immunosuppression Inhibition Interferon Interferon regulatory factor 3 Kinases Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - immunology Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism Major histocompatibility complex Medicine and Health Sciences Mesenchyme Metastases Myeloid leukemia NF-κB protein Pathways Pattern recognition Pattern recognition receptors Phosphoric Monoester Hydrolases - deficiency Phosphoric Monoester Hydrolases - genetics Promotion Protein kinase Proteins Receptors Ribonucleic acid RNA Sp1 protein Stat1 protein Transcription Tryptophan
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