Modulation of microRNA Expression in Subjects with Metabolic Syndrome and Decrease of Cholesterol Efflux from Macrophages via microRNA-33-Mediated Attenuation of ATP-Binding Cassette Transporter A1 Expression by Statins

Metabolic syndrome (MetS) is a complicated health problem that encompasses a variety of metabolic disorders. In this study, we analyzed the relationship between the major biochemical parameters associated with MetS and circulating levels of microRNA (miR)-33, miR-103, and miR-155. We found that miRN...

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Veröffentlicht in:	PloS one 2016-05, Vol.11 (5), p.e0154672-e0154672
Hauptverfasser:	Chen, Wei-Ming, Sheu, Wayne H-H, Tseng, Pei-Chi, Lee, Tzong-Shyuan, Lee, Wen-Jane, Chang, Pey-Jium, Chiang, An-Na
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions ABC transporters ABCA1 protein Abnormalities Analysis Animals Atherosclerosis Atorvastatin ATP ATP Binding Cassette Transporter 1 - genetics ATP-binding protein Biochemistry Biological Transport - drug effects Biology and Life Sciences Bone marrow Cardiovascular disease Cholesterol Cholesterol - metabolism Complications and side effects Development and progression Diabetes Dosage and administration Down-Regulation - drug effects Down-Regulation - genetics Drugs Efflux Endocrinology Federal regulation Female Gastroenterology Gene expression Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Gene regulation Genetic aspects Glucose Glucose - pharmacology Hemoglobin Hepatology High density lipoprotein Homeostasis Homeostasis - drug effects Hospitals Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hyperglycemia Internal medicine Low density lipoprotein Macrophages Macrophages - drug effects Macrophages - metabolism Male Medicine Medicine and Health Sciences Metabolic disorders Metabolic syndrome Metabolic Syndrome - genetics Metabolic Syndrome - metabolism Metabolic syndrome X Mice MicroRNA MicroRNAs MicroRNAs - genetics Middle Aged miRNA Modulation Molecular biology Physical Sciences Physiological aspects Post-transcription Proteins RAW 264.7 Cells Ribonucleic acid RNA Statins Systemic diseases
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